Hyperexpression of Chicken Riboflavin Carrier Protein: Antibodies to the Recombinant Protein Curtail Pregnancy in Rodents

1996 ◽  
Vol 7 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Sooryanarayana ◽  
P.R. Adiga ◽  
Sandhya S. Visweswariah
Keyword(s):  
Recombinant Protein ◽  
Carrier Protein ◽  
Riboflavin Carrier Protein

scholarly journals Riboflavin-Targeted Drug Delivery

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 295 ◽  
Author(s):  
Milita Darguzyte ◽  
Natascha Drude ◽  
Twan Lammers ◽  
Fabian Kiessling
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Review Article ◽  
Carrier Protein ◽  
Tumor Stem Cells ◽  
Vitamin B9 ◽  
Riboflavin Carrier Protein ◽  
Targeted Drug ◽  
The 1960S ◽  
Tumor Types

Active targeting can improve the retention of drugs and drug delivery systems in tumors, thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are overexpressed in many cancers are promising targets. In the last decade, attention and research were mainly centered on vitamin B9 (folate) targeting; however, the focus is slowly shifting towards vitamin B2 (riboflavin). Interestingly, while the riboflavin carrier protein was discovered in the 1960s, the three riboflavin transporters (RFVT 1-3) were only identified recently. It has been shown that riboflavin transporters and the riboflavin carrier protein are overexpressed in many tumor types, tumor stem cells, and the tumor neovasculature. Furthermore, a clinical study has demonstrated that tumor cells exhibit increased riboflavin metabolism as compared to normal cells. Moreover, riboflavin and its derivatives have been conjugated to ultrasmall iron oxide nanoparticles, polyethylene glycol polymers, dendrimers, and liposomes. These conjugates have shown a high affinity towards tumors in preclinical studies. This review article summarizes knowledge on RFVT expression in healthy and pathological tissues, discusses riboflavin internalization pathways, and provides an overview of RF-targeted diagnostics and therapeutics.

Characterization of antibodies to chicken riboflavin carrier protein: Antigenicity of the tryptic fragments

1990 ◽  
Vol 15 (4) ◽  
pp. 341-350 ◽  
Author(s):  
Usha Natraj ◽  
K. S. N. Iyer ◽  
Vijaya Raghavan ◽  
Smita Mahale ◽  
Jacintha Pereira
Keyword(s):  
Carrier Protein ◽  
Riboflavin Carrier Protein

scholarly journals Riboflavin carrier protein: A serum and tissue marker for breast carcinoma

2001 ◽  
Vol 95 (5) ◽  
pp. 277-281 ◽  
Author(s):  
Anjali A. Karande ◽  
Lakshmi Sridhar ◽  
K.S. Gopinath ◽  
P. Radhakantha Adiga
Keyword(s):  
Breast Carcinoma ◽  
Protein A ◽  
Carrier Protein ◽  
Riboflavin Carrier Protein ◽  
Tissue Marker
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