Effects of ibudilast on hippocampal long-term potentiation and passive avoidance responses in rats with transient cerebral ischemia

2002 ◽  
Vol 45 (4) ◽  
pp. 305-311 ◽  
Author(s):  
Mitsuhiro Yoshioka ◽  
Noriyuki Suda ◽  
Kiyoshi Mori ◽  
Ken-ichi Ueno ◽  
Yoshitada Itoh ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Passive Avoidance ◽  
Long Term Potentiation ◽  
Transient Cerebral Ischemia ◽  
Term Potentiation ◽  
Avoidance Responses

scholarly journals GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Yuanyuan Xu ◽  
Mike T. Lin ◽  
Xiang-ming Zha
Keyword(s):  
Passive Avoidance ◽  
Pyramidal Neurons ◽  
Granule Cells ◽  
Hippocampal Slices ◽  
Synaptic Cleft ◽  
Long Term Potentiation ◽  
Synaptic Function ◽  
Metabotropic Receptor ◽  
Term Potentiation

Abstract Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a neurotransmitter. However, it remains unclear whether protons signal through a metabotropic receptor to regulate synaptic function. Here, we showed that GPR68, a proton-sensitive GPCR, exhibited wide expression in the hippocampus, with higher expression observed in CA3 pyramidal neurons and dentate granule cells. In organotypic hippocampal slice neurons, ectopically expressed GPR68-GFP was present in dendrites, dendritic spines, and axons. Recordings in hippocampal slices isolated from GPR68−/− mice showed a reduced fiber volley at the Schaffer collateral-CA1 synapses, a reduced long-term potentiation (LTP), but unaltered paired-pulse ratio. In a step-through passive avoidance test, GPR68−/− mice exhibited reduced avoidance to the dark chamber. These findings showed that GPR68 contributes to hippocampal LTP and aversive fear memory.

scholarly journals Correction to: GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yuanyuan Xu ◽  
Mike T. Lin ◽  
Xiang-ming Zha
Keyword(s):  
Passive Avoidance ◽  
Avoidance Behavior ◽  
Long Term Potentiation ◽  
Passive Avoidance Behavior ◽  
Term Potentiation

An amendment to this paper has been published and can be accessed via the original article.

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