Protection by nitric oxide of morphine-induced inhibition of rat submandibular gland function

2002 ◽  
Vol 45 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Mohammad Abdollahi ◽  
Hajar Safarhamidi
Keyword(s):  
Nitric Oxide ◽  
Submandibular Gland ◽  
Gland Function ◽  
Rat Submandibular Gland

Role of nitric oxide in the regulation of blood flow in the rat submandibular gland during carotid artery occlusion

2001 ◽  
Vol 46 (3) ◽  
pp. 261-267 ◽  
Author(s):  
János Vág ◽  
Csilla Hably ◽  
Beáta Kerémi ◽  
Eszter Kovács ◽  
Jenő Bartha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Carotid Artery ◽  
Submandibular Gland ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Rat Submandibular Gland

scholarly journals Nitric oxide in the control of submandibular gland function in the anaesthetized ferret

1997 ◽  
Vol 82 (5) ◽  
pp. 825-836 ◽  
Author(s):  
G Tobin ◽  
AV Edwards ◽  
SR Bloom ◽  
J Ekstrom
Keyword(s):  
Nitric Oxide ◽  
Submandibular Gland ◽  
Gland Function

Protection by selenium of lead-acetate-induced alterations on rat submandibular gland function

2001 ◽  
Vol 20 (1) ◽  
pp. 28-33 ◽  
Author(s):  
M Abdollahi ◽  
N Rahmat-Jirdeh ◽  
K Soltaninejad
Keyword(s):  
Drinking Water ◽  
Submandibular Gland ◽  
Flow Rate ◽  
Lead Acetate ◽  
Membrane Integrity ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Gland Function ◽  
Rat Submandibular Gland

Pure submandibular saliva was collected intraorally by micro polyethylene cannulation of anaesthetized rats using pilocarpine as a secretagogue. Twenty-four days treatment with lead acetate 0.05% in drinking water altered salivary function. Except for flow rate that was (P <0.01) increased by lead acetate, the reminder of parameters, concentrations of total protein and calcium and the activity of N-acetyl-β-D-glucosaminidase (NAG) in submandibular secretions were decreased significantly (P< 0.01) by lead acetate. Selenium (2.5 mg 1-l) in drinking water for 24 days did not induce any significant change in saliva secretory function. Pretreatment by selenium, prevented the lead acetate-induced decrease of NAG activity and concentrations of calcium and protein (P<0.01). The increased flow rate by lead acetate was also affected by selenium pretreatment and reached the level of control. It is concluded that selenium can protect rat submandibular gland function from lead-acetate-induced adverse effects. Properties of selenium as an antioxidant, free radical scavenger and maintenance of cell membrane integrity may be possible mechanisms of its protective effects.

scholarly journals H1-Receptor activation triggers the endogenous nitric oxide signalling system in the rat submandibular gland

2002 ◽  
Vol 11 (6) ◽  
pp. 337-343 ◽  
Author(s):  
Enri Borda ◽  
Graciela Stranieri ◽  
Leonor Sterin-Borda
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Nitric Oxide Synthase ◽  
Submandibular Gland ◽  
Cyclic Gmp ◽  
Amylase Release ◽  
Kinase C ◽  
Oxide Synthase ◽  
Rat Submandibular Gland

Background: Histamine is released from mast cells by immunologic and non-immunologic stimuli during salivary gland inflammation, regulating salivary secretion. The receptor-secretory mechanism has not been studied in detail.Aims: The studies reported were directed toward elucidating signal transduction/second messenger pathways within the rat submandibular gland associated with 2-thiazolylethylamine (ThEA)-induced H1-receptor responses.Materials and methods: To assess the H1receptor subtype expression in the rat submandibular gland, a radioligand binding assay was performed. The study also included inositolphosphates and cyclic GMP accumulation, protein kinase C and nitric oxide synthase activities, and amylase release.Results: The histamine H1receptor subtype is expressed on the rat submandibular gland with high-affinity binding sites. The ThEA effect was associated with activation of phosphoinositide-specific phospholipase C, translocation of protein kinase C, stimulation of nitric oxide synthase activity and increased production of cyclic GMP. ThEA stimulation of nitric oxide synthase and cyclic GMP was blunted by agents able to interfere with calcium movilization, while a protein kinase C inhibitor was able to stimulate ThEA action. On the other hand, ThEA stimulation evoked amylase release via the H1receptor but was not followed by the L-arginine/nitric oxide pathway activation.Conclusions: These results suggest that, apart from the effect of ThEA on amylase release, it also appears to be a vasoactive chemical mediator that triggers vasodilatation, modulating the course of inflammation.

Restoration of morphine-induced alterations in rat submandibular gland function by N-methyl-D-aspartate agonist

2006 ◽  
Vol 57 (3) ◽  
pp. 283-294 ◽  
Author(s):  
N. Hashemi ◽  
Azadeh Mohammadirad ◽  
Zahra Bayrami ◽  
R. Khorasani ◽  
Sanaz Vosough ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Gland Function ◽  
Rat Submandibular Gland
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