The antinociceptive effect of moclobemide on the vocalization threshold to paw pressure in a rat model of unilateral mononeuropathy

2001 ◽  
Vol 44 (6) ◽  
pp. 503-507 ◽  
Author(s):  
Sebnem Apaydin ◽  
Esin Goldeli ◽  
Meltem Uyar ◽  
Elvan Erhan ◽  
Ibrahim Yegul ◽  
...  
Keyword(s):  
Rat Model ◽  
Antinociceptive Effect ◽  
Vocalization Threshold

Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain

2021 ◽  
Vol 899 ◽  
pp. 174029
Author(s):  
Sang Wan Ryu ◽  
Yeo Ok Kim ◽  
Han-Byul Kim ◽  
Seog Bae Oh ◽  
Jeong Il Choi ◽  
...  
Keyword(s):  
Rat Model ◽  
Inflammatory Pain ◽  
Antinociceptive Effect

scholarly journals Preconditioning with hydrogen sulfide prevents bone cancer pain in rats through a proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway

2017 ◽  
Vol 243 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Li Zhuang ◽  
Ke Li ◽  
Gaowei Wang ◽  
Tao Shou ◽  
Chunlin Gao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Rat Model ◽  
Mechanical Allodynia ◽  
Antinociceptive Effect ◽  
Thermal Hyperalgesia ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Kinase Pathway

Bone cancer pain (BCP) is a severe type of hyperpathic pain occurring with primary bone tumors or advanced cancers which metastasize to bones. BCP can detrimentally reduce quality of life and presents a challenge to modern medicine. Studies have shown that exogenous H2S may act as a neuroprotectant to protect against some diseases in central nervous system. The preset study aimed to investigate the antinociceptive effect of H2S in BCP. We first measured the changes of serum H2S in patients with BCP and analyzed the relationship between them, then investigated the effect of H2S preconditioning on BCP, and explored the mechanism in rat model. Our results revealed that serum H2S level was negatively correlated with pain scores. In the rat model of BCP, preconditioning with H2S significantly reduced BCP, demonstrated by the decrease of thermal hyperalgesia and mechanical allodynia. The mechanism of H2S preconditioning may involve microglia deactivation and inflammation inhibition in the spinal cord, in which the proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway is activated. Impact statement Bone cancer pain (BCP) significantly decreases the life quality of patients or their life expectancy and causes a severe health burden to the society. However, as the exact mechanism of BCP is still poorly understood, no effective treatment has been developed yet. There are some pain medicines now, but they have some inevitable side effects. Additional therapeutic strategies are urgently needed. First, we revealed that preconditioning with H2S significantly reduced BCP, demonstrated by the decrease of thermal hyperalgesia and mechanical allodynia. Second, the mechanism of H2S preconditioning was elucidated. It may involve microglia deactivation and inflammation inhibition in the spinal cord, in which the proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway is activated. This novel finding may significantly help us to understand the difference between the roles of endogenous H2S and exogenous H2S in the development of BCP and present us a new strategy of pain management.

Ascending Nociceptive Control Contributes to the Antinociceptive Effect of Acupuncture in a Rat Model of Acute Pain

2014 ◽  
Vol 15 (4) ◽  
pp. 422-434 ◽  
Author(s):  
Glaucia Tobaldini ◽  
Betina Aisengart ◽  
Marcelo M.S. Lima ◽  
Claudia H. Tambeli ◽  
Luana Fischer
Keyword(s):  
Acute Pain ◽  
Rat Model ◽  
Antinociceptive Effect

Moxibustion at ST36 Alleviates Pain in Complete Freund's Adjuvant-Induced Arthritic Rats

2006 ◽  
Vol 34 (01) ◽  
pp. 57-67 ◽  
Author(s):  
Jae-Hyo Kim ◽  
Hee-Kee Kim ◽  
Yong-Il Park ◽  
In-Churl Sohn ◽  
Dong-Ok Choi ◽  
...  
Keyword(s):  
Protein Expression ◽  
Rat Model ◽  
Antinociceptive Effect ◽  
Complete Freund’S Adjuvant ◽  
No Production ◽  
Western Blots ◽  
Antinociceptive Effects ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

This study was to investigate the antinociceptive effects of moxibustion in a complete Freund's adjuvant (CFA)-induced arthritic rat model, and the effects of moxibustion on immunohistochemical changes at the spinal cord level. Moxibustion was applied to the ipsilateral (right) Zusanli (ST36) acupoint to the lesion side for 9 days to CFA-induced arthritic rats. The stepping force was measured as a behavioral test, c-Fos immunohistochemistry, NO production and nNOS Western blots were examined to evaluate antinociceptive effects. Moxibustion at ST36 significantly improved the stepping force in the affected hind limb in CFA-induced arthritis. Moreover, moxibustion at ST36 suppressed the production of NO and the protein expression of c-Fos and nNOS induced by arthritis. These results suggest that moxibustion at ST36 has a potent antinociceptive effect in an arthritic rat model, and modulates neuronal excitability and endogenous NO production by suppressing c-Fos and nNOS protein expression.

P.6.054 The antinociceptive effect of oxcarbazepine in a rat model of inflammatory hyperalgesia

2004 ◽  
Vol 14 ◽  
pp. S379
Author(s):  
M. Tomic ◽  
S. Vuckovic ◽  
R. Stepanovic-Petrovic ◽  
N. Ugresic ◽  
M. Prostran ◽  
...  
Keyword(s):  
Rat Model ◽  
Antinociceptive Effect ◽  
Inflammatory Hyperalgesia

Antinociceptive effect of (S)-N-desmethyl trimebutine against a mechanical stimulus in a rat model of peripheral neuropathy

Life Sciences ◽  
1999 ◽  
Vol 66 (5) ◽  
pp. 433-439 ◽  
Author(s):  
Valérie Kayser ◽  
Dennis Christensen ◽  
Giséle Guilbaud ◽  
François Roman
Keyword(s):  
Peripheral Neuropathy ◽  
Rat Model ◽  
Antinociceptive Effect ◽  
Mechanical Stimulus

Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain

2017 ◽  
Vol 69 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Renata Wolińska ◽  
Anna Leśniak ◽  
Małgorzata Żochowska ◽  
Mariusz Sacharczuk ◽  
Katarzyna Kieć-Kononowicz ◽  
...  
Keyword(s):  
Acute Pain ◽  
Rat Model ◽  
Antinociceptive Effect ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor
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