Differences in the behaviour of Sprague–Dawley and Lewis rats during repeated passive avoidance procedure: effect of amphetamine

2001 ◽  
Vol 44 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Ondrej Kaminsky ◽  
Vera Klenerova ◽  
Jiri Stöhr ◽  
Pavel Sida ◽  
Sixtus Hynie
Keyword(s):  
Passive Avoidance ◽  
Sprague Dawley ◽  
Lewis Rats ◽  
Avoidance Procedure

Impaired passive avoidance acquisition in Sprague–Dawley and Lewis rats after restraint and cold stress

2002 ◽  
Vol 136 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Věra Klenerová ◽  
Ondřej Kaminský ◽  
Pavel Šı́da ◽  
Ivan Krejčı́ ◽  
Zdeněk Hliňák ◽  
...  
Keyword(s):  
Cold Stress ◽  
Passive Avoidance ◽  
Avoidance Acquisition ◽  
Sprague Dawley ◽  
Lewis Rats

The comparative study of Sprague–Dawley and Lewis rats in adjuvant-induced arthritis

2006 ◽  
Vol 373 (2) ◽  
pp. 140-147 ◽  
Author(s):  
X. Cai ◽  
Y. F. Wong ◽  
H. Zhou ◽  
Y. Xie ◽  
Z. Q. Liu ◽  
...  
Keyword(s):  
Comparative Study ◽  
Sprague Dawley ◽  
Lewis Rats ◽  
Adjuvant Induced Arthritis ◽  
The Comparative Study

The Impact of Mild Emotional Stress Induced by the Passive Avoidance Procedure on Immune Reactivity

1987 ◽  
Vol 496 (1 Neuroimmune I) ◽  
pp. 477-484 ◽  
Author(s):  
GERDA CROISET ◽  
H. DICK VELDHUIS ◽  
R. E. BALLIEUX ◽  
D. WIED ◽  
COBI J. HEIJNEN
Keyword(s):  
Passive Avoidance ◽  
Emotional Stress ◽  
Immune Reactivity ◽  
Avoidance Procedure ◽  
The Impact

Comparative studies on tryptophan binding to hepatic nuclear envelopes in Sprague-Dawley and Lewis rats

1994 ◽  
Vol 267 (2) ◽  
pp. R502-R507 ◽  
Author(s):  
H. Sidransky ◽  
E. Verney
Keyword(s):  
Inflammatory Diseases ◽  
Specific Binding ◽  
Quantitative Difference ◽  
Sprague Dawley ◽  
Lewis Rats ◽  
Sprague Dawley Rats ◽  
Nuclear Rna ◽  
Eosinophilia Myalgia Syndrome

Since Lewis rats are susceptible to many inflammatory diseases and have been used in an experimental model of the eosinophilia-myalgia syndrome, we investigated whether Lewis rats would respond to L-tryptophan as have Sprague-Dawley rats reported earlier. In this comparative study using females of both strains, we observed a decrease in the affinity of in vitro L-tryptophan binding to hepatic nuclei and nuclear envelopes of Lewis rats compared with Sprague-Dawley rats. However, in vivo stimulatory effects of administering L-tryptophan on hepatic polyribosomal aggregation, protein synthesis, and nuclear RNA release were similar in both strains. In vitro [3H]tryptophan binding to hepatic nuclear envelopes, using L-tryptophan implicated in cases of the eosinophilia-myalgia syndrome, revealed less specific binding than when using nonimplicated L-tryptophan in both strains. The possible significance of the quantitative difference in the binding affinity of L-tryptophan to hepatic nuclei of Lewis rats compared with those of Sprague-Dawley rats is as yet undetermined.

Effects of a Mixture of Pesticides on the Adult Female Reproductive System of Sprague-Dawley, Wistar, and Lewis Rats

2015 ◽  
Vol 78 (9) ◽  
pp. 602-616 ◽  
Author(s):  
Viviane M. Pascotto ◽  
Marina T. Guerra ◽  
Janete Aparecida Anselmo Franci ◽  
João Lauro V. de Camargo ◽  
Wilma G. Kempinas ◽  
...  
Keyword(s):  
Adult Female ◽  
Reproductive System ◽  
Female Reproductive System ◽  
Sprague Dawley ◽  
Lewis Rats

ß-adrenergic receptor blockade by propranolol enhances retention in a multitrial passive-avoidance procedure.

2000 ◽  
Vol 114 (6) ◽  
pp. 1256-1260 ◽  
Author(s):  
Allen M. Scheider ◽  
Nancy S. Koven ◽  
Kimberly A. Lombardo ◽  
Dimitriy A. Levin ◽  
Peter E. Simson
Keyword(s):  
Passive Avoidance ◽  
Adrenergic Receptor ◽  
Receptor Blockade ◽  
Avoidance Procedure ◽  
Adrenergic Receptor Blockade

scholarly journals MATERNALLY INDUCED TRANSPLANTATION IMMUNITY, TOLERANCE, AND RUNT DISEASE IN RATS

1972 ◽  
Vol 135 (4) ◽  
pp. 808-826 ◽  
Author(s):  
Alan E. Beer ◽  
R. E. Billingham ◽  
S. L. Yang
Keyword(s):  
Intraperitoneal Injection ◽  
Lymphoid Cells ◽  
Sprague Dawley ◽  
F1 Hybrid ◽  
Lewis Rats ◽  
Sprague Dawley Rats ◽  
Tissue Antigens ◽  
Tissue System ◽  
Fischer Rats ◽  
Induction Of Tolerance

A previous report that the offspring of outbred Sprague-Dawley rats, born of mothers presensitized or tolerant with respect to tissue antigens of the Lewis strain, and reinoculated with Lewis cells during their pregnancy, reject test grafts of Lewis skin in an accelerated manner has been confirmed. This "maternally induced" alteration in reactivity of the progeny has been found to be long lasting, immunologically specific, and probably not due to transfer of humoral antibody. It has been established that the reexposure of the mothers to donor cellular antigen during pregnancy augmented the influence of the prior states of tolerance or sensitivity. To obviate the complications inherent in working with the outbred Sprague-Dawley rats, the key experiments summarized above were repeated with isogenic Fischer rats as parents and Lewis rats as the tissue donors as before. With this combination it was found that a state of prior sensitization or tolerance in the mothers resulted in the apparent induction of tolerance in some of their progeny. Reinoculation of either the tolerant or sensitized mothers during pregnancy slightly increased the incidence and degree of impairment of their offsprings' capacity to reject Lewis skin grafts. A single intraperitoneal injection of 100 x 106 million Lewis lymphoid cells into normal Fischer rats in the 14th–16th day of pregnancy also weakened the reactivity of their progeny to Lewis test grafts. Further to test the premise that this weakened reactivity might be due to maternal induction of tolerance, by antenatal transmission of alien cells, the lymphohematopoietic tissue system of adult Fischer females was replaced by that from Lewis donors with the aid of cyclophosphamide. It was anticipated that when these animals were mated with Fischer males, sufficient Lewis leukocytes might cross the placentas to induce high degrees of tolerance. Although normal sized healthy litters were born, about 50% of the infants succumbed to graft-versus-host (GVH) or runt disease within 40 days, many of them giving evidence of being tolerant of Lewis grafts. The mothers, too, developed chronic GVH disease. The offspring of Fischer females made chimeric with cells from (Fischer x Lewis)F1 hybrid donors, as well as their mothers, remained healthy. Intraperitoneal injection of normal Fischer females, in the 15th–17th day of pregnancy, with 100 million lymphoid cells from specifically sensitized Lewis rats, also caused fatal runt disease to develop in about 50% of their offspring, but left the mothers unscathed. Taken together, these various findings indicate that in some genetic contexts at least the extent of the natural surreptitious transplacental cellular traffic can be considerably augmented experimentally, though how this comes about and why lymphocytic cells that are foreign to the mother can apparently gain access to fetuses more readily than her own cells remain to be determined.

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