ANTINOCICEPTIVE EFFECTS OF THE HYDROPHILIC α2-ADRENOCEPTOR AGONIST ST-91 IN DIFFERENT TEST CIRCUMSTANCES AFTER INTRATHECAL ADMINISTRATION TO WISTAR RATS

1997 ◽  
Vol 35 (6) ◽  
pp. 561-568
Author(s):  
GYÖNGI HORVÁTH ◽  
ILDIKÓ DOBOS ◽  
PÉTER LISZLI ◽  
WALTER KLIMSCHA ◽  
MARGIT SZIKSZAY ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Intrathecal Administration ◽  
Α2 Adrenoceptor ◽  
Adrenoceptor Agonist ◽  
Antinociceptive Effects

A robust GTP-induced shift in α2-adrenoceptor agonist affinity in tissue sections from rat brain

2001 ◽  
Vol 105 (2) ◽  
pp. 159-166 ◽  
Author(s):  
David B Bylund ◽  
Moira E Gerety ◽  
H.Kevin Happe ◽  
L.Charles Murrin
Keyword(s):  
Rat Brain ◽  
Tissue Sections ◽  
Agonist Affinity ◽  
Α2 Adrenoceptor ◽  
Adrenoceptor Agonist

Does the Binding Duration of a Partial α2-adrenoceptor Agonist Exceed its Activation Interval at the Autoreceptor?

2005 ◽  
Vol 1 (4) ◽  
pp. 299-310 ◽  
Author(s):  
Marc Steffens ◽  
Anna Olayioye . ◽  
Boris Huber . ◽  
Clemens Allgaier . ◽  
Thomas J. Feuerstein .
Keyword(s):  
Α2 Adrenoceptor ◽  
Adrenoceptor Agonist

scholarly journals Vagally mediated gastric effects of brain stem α2-adrenoceptor activation in stressed rats

2018 ◽  
Vol 314 (4) ◽  
pp. G504-G516 ◽  
Author(s):  
Yanyan Jiang ◽  
Kirsteen N. Browning ◽  
Luca Toti ◽  
R. Alberto Travagli
Keyword(s):  
Chronic Stress ◽  
Acute Stress ◽  
Gastric Tone ◽  
Α2 Adrenoceptor ◽  
Adrenoceptor Agonist ◽  
Cholinergic Tone ◽  
Relevant Role ◽  
In Vivo Effects

Chronic stress exerts vagally dependent effects to disrupt gastric motility; previous studies have shown that, among other nuclei, A2 neurons are involved in mediating these effects. Several studies have also shown robust in vitro and in vivo effects of α2-adrenoceptor agonists on vagal motoneurons. We have demonstrated previously that brainstem vagal neurocircuits undergo remodeling following acute stress; however, the effects following brief periods of chronic stress have not been investigated. Our aim, therefore, was to test the hypothesis that different types of chronic stress influence gastric tone and motility by inducing plasticity in the response of vagal neurocircuits to α2-adrenoreceptor agonists. In rats that underwent 5 days of either homotypic or heterotypic stress loading, we applied the α2-adrenoceptor agonist, UK14304, either by in vitro brainstem perfusion to examine its ability to modulate GABAergic synaptic inputs to vagal motoneurons or in vivo brainstem microinjection to observe actions to modulate antral tone and motility. In neurons from naïve rats, GABAergic currents were unresponsive to exogenous application of UK14304. In contrast, GABAergic currents were inhibited by UK14304 in all neurons from homotypic and, in a subpopulation of neurons, heterotypic stressed rats. In control rats, UK14304 microinjection inhibited gastric tone and motility via withdrawal of vagal cholinergic tone; in heterotypic stressed rats, the larger inhibition of antrum tone was due to a concomitant activation of peripheral nonadrenergic, noncholinergic pathways. These data suggest that stress induces plasticity in brainstem vagal neurocircuits, leading to an upregulation of α2-mediated responses. NEW & NOTEWORTHY Catecholaminergic neurons of the A2 area play a relevant role in stress-related dysfunction of the gastric antrum. Brief periods of chronic stress load induce plastic changes in the actions of adrenoceptors on vagal brainstem neurocircuits.

Effects of the α2-adrenoceptor agonist guanfacine on growth and thermogenesis in mice

1992 ◽  
Vol 70 (11) ◽  
pp. 3429-3434 ◽  
Author(s):  
M. N. Sillence ◽  
G. D. Tudor ◽  
M. L. Matthews ◽  
D. B. Lindsay
Keyword(s):  
Α2 Adrenoceptor ◽  
Adrenoceptor Agonist

A novel and facile route for the synthesis of medetomidine as the α2-adrenoceptor agonist

2017 ◽  
Vol 14 (8) ◽  
pp. 1735-1739
Author(s):  
Babak Kaboudin ◽  
Hamideh Haghighat ◽  
Samira Aieni ◽  
Leila Behrouzi ◽  
Foad Kazemi ◽  
...  
Keyword(s):  
Α2 Adrenoceptor ◽  
Adrenoceptor Agonist ◽  
Facile Route
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