Histochemical and Immunohistochemical Localization of Neuronal Nitric Oxide Synthase in the Olfactory Epithelium of the Axolotl, Ambystoma mexicanum

Nitric Oxide ◽  
2001 ◽  
Vol 5 (4) ◽  
pp. 302-316 ◽  
Author(s):  
Eduardo Sánchez-Islas ◽  
Martha León-Olea
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Olfactory Epithelium ◽  
Neuronal Nitric Oxide Synthase ◽  
Immunohistochemical Localization ◽  
Ambystoma Mexicanum ◽  
Oxide Synthase

Neuronal nitric oxide synthase-like immunoreactivity in olfactory epithelium throughout the life cycle of the sea lamprey, Petromyzon marinus L.

2000 ◽  
Vol 78 (3) ◽  
pp. 346-351 ◽  
Author(s):  
Hong N Hua ◽  
Aliya U Zaidi ◽  
Barbara S Zielinski
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Olfactory Epithelium ◽  
Olfactory Receptor ◽  
Petromyzon Marinus ◽  
Neuronal Nitric Oxide Synthase ◽  
Sea Lamprey ◽  
Olfactory Receptor Neurons ◽  
Receptor Neurons ◽  
Oxide Synthase

This study is the first to show that neuronal nitric oxide synthase-like immunoreactivity is located in the olfactory epithelium at all developmental stages of a vertebrate. Western immunoblotting of sea lamprey (Petromyzon marinus L.) olfactory mucosa with a monoclonal antibody against the NADPH-binding epitope of neuronal nitric oxide synthase showed that the molecular mass of this protein was 200 kDa. In the larval stage, neuronal nitric oxide synthase-like immunoreactivity was strongest in the basal region of the olfactory epithelium, the site of proliferating olfactory receptor neurons. This staining gradually diminished as the life cycle progressed. In the juvenile stage, the intensity of neuronal nitric oxide synthase-like immunoreactivity was striking in the wide cell bodies and dendrites on olfactory receptor neurons. These results confirm previous evidence that nitric oxide modulates development in the olfactory epithelium.

The immunohistochemical localization of neuronal nitric oxide synthase in the basal forebrain of the dog

2006 ◽  
Vol 31 (3) ◽  
pp. 200-209 ◽  
Author(s):  
Laura Menéndez ◽  
Daniel Insua ◽  
José Luis Rois ◽  
Germán Santamarina ◽  
María Luisa Suárez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Basal Forebrain ◽  
Neuronal Nitric Oxide Synthase ◽  
Immunohistochemical Localization ◽  
Oxide Synthase
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