Nitric Oxide Synthase Activity in Retinas from Non-Insulin-Dependent Diabetic Goto-Kakizaki Rats: Correlation with Blood–Retinal Barrier Permeability

Nitric Oxide ◽  
2000 ◽  
Vol 4 (6) ◽  
pp. 590-596 ◽  
Author(s):  
A. Carmo ◽  
J.G. Cunha-Vaz ◽  
A.P. Carvalho ◽  
M.C. Lopes
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Retinal Barrier ◽  
Barrier Permeability ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

Increased prostaglandin E generation and enhanced nitric oxide synthase activity in the non-insulin-dependent diabetic embryo during organogenesis

1998 ◽  
Vol 10 (2) ◽  
pp. 191 ◽  
Author(s):  
Alicia Jawerbaum ◽  
Elida T. Gonzalez ◽  
Virginia Novaro ◽  
Alicia Faletti ◽  
Debora Sinner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Congenital Abnormalities ◽  
Prostaglandin E ◽  
No Donor ◽  
Insulin Dependent ◽  
Nos Inhibitor ◽  
Insulin Dependent Diabetic ◽  
Oxide Synthase

Embryonic development, prostaglandin E (PGE) generation and nitric oxide synthase (NOS) activity during organogenesis were evaluated in an experimental rat model of non-insulin- dependent diabetes (NIDD) generated by neonatal administration of streptozotocin. Gross malformations were detected in 5% of NIDD embryos and these embryos were all non-viable; in the other 95%, growth was retarded but no congenital abnormalities were found. Control embryos were all alive and not malformed. The NIDD 11-day embryos secreted more PGE into the incubation medium than did controls. The NO donor SIN–1 increased PGE production in both control and NIDD embryos. A NOS inhibitor (L-NMMA) reduced PGE generation in both experimental groups, suggesting a modulatory role of NO on embryonic PGE production. Activity of NOS was higher in NIDD 11-day embryos than in controls. Treatment in vivo of control and NIDD rats (Days 7–11 of gestation) with a NOS inhibitor (L-NAME; 5 mg kg-1 i.p.) reduced embryonic PGE production and induced a higher resorption rate and an increase in neural-tube defects. The results suggest that NO modulates PGE generation in the organogenetic embryo. In the NIDD model, overproduction of NO is observed, this NO probably enhancing embryonic PGE production. The relationship between PGE generation and the appearance of congenital abnormalities is discussed.

Effect of KH-305 on the Nitric Oxide Synthase Activity and Erectile Dysfunction in Young Rats

2007 ◽  
Vol 36 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Eun-Jeong Lee ◽  
Hee-Seok Kim ◽  
Byoung-Chul Kim ◽  
Sung-Wan Hwang ◽  
Sung-Yeoun Hwang
Keyword(s):  
Nitric Oxide ◽  
Erectile Dysfunction ◽  
Nitric Oxide Synthase ◽  
Young Rats ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

Inhibition of Nitric Oxide Synthase Activity by Zn2+ Ion

Biochemistry ◽  
1995 ◽  
Vol 34 (46) ◽  
pp. 15091-15095 ◽  
Author(s):  
Anthony Persechini ◽  
Kirk McMillan ◽  
Bettie Sue Siler Masters
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

scholarly journals Time Course of Inducible Nitric Oxide Synthase Activity Following Endotoxin Administration in Dogs

Nitric Oxide ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 208-211 ◽  
Author(s):  
Jean-Charles Preiser ◽  
Haibo Zhang ◽  
Bernard Vray ◽  
Andreas Hrabak ◽  
Jean-Louis Vincent
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Time Course ◽  
Endotoxin Administration ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

Neuroprotective Effect of Chuk-Me-Sun-Dan on NMDA- and AMPA-Evoked Nitric Oxide Synthase Activity in Mouse Brain

2005 ◽  
Vol 27 (3) ◽  
pp. 499-514 ◽  
Author(s):  
Byung-Soo Koo ◽  
Eun-Gyu Choi ◽  
Jae-Bok Park ◽  
Chang-Ho Cho ◽  
Kang-Hyun Chung ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mouse Brain ◽  
Neuroprotective Effect ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

scholarly journals Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Massimo Lazzaro ◽  
Barbara Bettegazzi ◽  
Marco Barbariga ◽  
Franca Codazzi ◽  
Daniele Zacchetti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cytokine Secretion ◽  
Activated Microglia ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity
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