Frontal Cerebral Perfusion Dysfunction in Elderly Late-Onset Major Depression Assessed by 99MTC-HMPAO Spect

NeuroImage ◽  
2001 ◽  
Vol 14 (1) ◽  
pp. 202-205 ◽  
Author(s):  
Vı́ctor Navarro ◽  
Cristóbal Gastó ◽  
Francisco Lomeña ◽  
José J. Mateos ◽  
Teodoro Marcos
Keyword(s):  
Major Depression ◽  
Cerebral Perfusion ◽  
Late Onset ◽  
Hmpao Spect ◽  
99Mtc Hmpao

scholarly journals 99mTc-HMPAO SPECT Study of Cerebral Perfusion After Treatment with Medication and Electroconvulsive Therapy in Major Depression

2007 ◽  
Vol 48 (8) ◽  
pp. 1273-1278 ◽  
Author(s):  
Y. Kohn ◽  
N. Freedman ◽  
H. Lester ◽  
Y. Krausz ◽  
R. Chisin ◽  
...  
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Cerebral Perfusion ◽  
Hmpao Spect ◽  
99Mtc Hmpao

scholarly journals Mood and Cerebral Perfusion Revisited

2000 ◽  
Vol 12 (1-2) ◽  
pp. 87-92 ◽  
Author(s):  
Klaus P. Ebmeier
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Medial Prefrontal Cortex ◽  
Cerebral Perfusion ◽  
Diurnal Variations ◽  
Anterior Cingulate ◽  
Neuropsychological Measures ◽  
Hmpao Spect ◽  
Regression Slopes ◽  
Positive Correlations

Twenty patients with major depression and observed diurnal variations of mood were examined using clinical and neuropsychological measures and perfusion HMPAO-SPECT at 8 a.m. and 8 p.m. In thirteen patients depression scores varied more than 15% although 4 patients with reverse diurnal variation caused mean group depression scores to be not different between morning and evening. There was an overall trend for higher depression scores to be associated with higher perfusion in posterior cingulate. This was mainly accounted for by significant positive correlations in the morning scan in posterior, but also anterior cingulate and medial prefrontal cortex compared with evening scans. This means that morning regression slopes were steeper than evening slopes. This result is discussed with regard to possible interpretations, such as adaptive or habituating changes during the day that may occur in depressed patients.

scholarly journals Cerebral Perfusion Changes in Older Delirious Patients Using 99mTc HMPAO SPECT

2006 ◽  
Vol 61 (12) ◽  
pp. 1294-1299 ◽  
Author(s):  
T. G. Fong ◽  
S. T. Bogardus ◽  
A. Daftary ◽  
E. Auerbach ◽  
H. Blumenfeld ◽  
...  
Keyword(s):  
Cerebral Perfusion ◽  
Hmpao Spect ◽  
99Mtc Hmpao

The Effect of Acetazolamide (DiamoxR) on Cerebral Perfusion in Migraine - An Interictal 99mTc-Hmpao-Spect Study

Cephalalgia ◽  
1991 ◽  
Vol 11 (11_suppl) ◽  
pp. 38-39
Author(s):  
H.-P. Schlake ◽  
I.G. Böttger ◽  
K.-H. Grotemeyer ◽  
I.W. Husstedt ◽  
O. Schober
Keyword(s):  
Cerebral Perfusion ◽  
Hmpao Spect ◽  
99Mtc Hmpao

Vergleich von MRT- und SPECT-Befunden bei Patienten mit zerebraler Mikroangiopathie

1991 ◽  
Vol 30 (05) ◽  
pp. 161-169 ◽  
Author(s):  
C. Weiller ◽  
R. Weigmann ◽  
H.-J. Kaiser ◽  
U. Büll ◽  
R. Schneider ◽  
...  
Keyword(s):  
White Matter Lesions ◽  
Central Nervous System Disease ◽  
Deep White Matter ◽  
Cranial Ct ◽  
System Disease ◽  
Ct Findings ◽  
Hmpao Spect ◽  
Significant Difference ◽  
Cerebral Microangiopathy ◽  
99Mtc Hmpao

Lacunar infarctions and periventricular hypodensity are assumed to be typical CT patterns of cerebral microangiopathy (MA). In 17 patients with such findings and in 6 controls without any signs of central nervous system disease cranial CT, MRT and 99mTc-HMPAO-SPECT were employed. In 7 patients with CT findings of minor MA demonstrated in comparison to controls no significant difference. In 10 cases with CT findings of pronounced MA periventricular rCBF was significantly reduced compared to controls. rCBF of temporal and parietal cortex were not diminished compared to controls. In 14 patients studied with MRT deep white matter lesions were found which appeared solitary, multiple or confluent. Employing 99mTc-HMPAO-SPECT, cerebral MA revealed rCBF reduction in periventricular brain tissue by cerebellar standardization.

Vorläufige Ergebnisse von 99mTc-HMPAO-SPECT-Untersuchungen bei endogenen Psychosen

1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regions Of Interest ◽  
Post Mortem ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses ◽  
The Brain ◽  
99Mtc Hmpao

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.

123J-Iomazenil- und 99mTc-HMPAO in der Diagnostik fokaler Epilepsien: Vergleich von unbehandelten und behandelten Patienten

1994 ◽  
Vol 33 (01) ◽  
pp. 01-07
Author(s):  
M. Cordes ◽  
B. Schmitz ◽  
J. Hierholzer ◽  
R. Siekmann ◽  
U. Keske ◽  
...  
Keyword(s):  
Hmpao Spect ◽  
99Mtc Hmpao

ZusammenfassungDie Daten von insgesamt 20 Patienten mit fokalen Epilepsien (beh.: 7; unbeh.: 13) wurden mit dem Ziel ausgewertet, Unterschiede in der Bindung der Radiotracer HMPAO und IM घ zwischen behandelten und unbehandelten Patienten herauszufinden. CT und MIRT zeigten keine pathologischen Befunde. Bei allen Patienten wurden mittels SPECT die Gesamthirnaktivität und durch Anwendung der ROI-Technik regionale Impulsdichten (Rl) bestimmt und der spezifische und unspezifische Anteil der Rl des BZ-Antagonisten für jede Region berechnet. In der Gruppe der beh. Patienten konnte eine signifikant höhere normalisierte Gesamtbindung von IMZ gefunden werden (p <0,001). Die spezifische Bindung von IMZ und die Gesamtbindung von HMPAO zeigten keine Unterschiede zwischen beiden Gruppen. Die IMZ-SPECT hatte in unserem Kollektiv gegenüber der HMPAO-SPECT in bezug auf das EEG eine höhere Sensitivität bei geringerer Spezifität im Nachweis einer Minderanreicherung des Tracers in Arealen mit fokaler hypersynchroner Erregungssteigerung.

Sign in / Sign up

Export Citation Format

Share Document