The Role of the Dorsolateral Prefrontal Cortex in Random Number Generation: A Study with Positron Emission Tomography

NeuroImage ◽  
2000 ◽  
Vol 12 (6) ◽  
pp. 713-725 ◽  
Author(s):  
M. Jahanshahi ◽  
G. Dirnberger ◽  
R. Fuller ◽  
C.D. Frith
Keyword(s):  
Positron Emission Tomography ◽  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Random Number ◽  
Random Number Generation ◽  
Emission Tomography ◽  
Number Generation ◽  
Positron Emission ◽  
Dorsolateral Prefrontal

scholarly journals The role of the prefrontal cortex in the go/no-go task in humans: a positron emission tomography study

2000 ◽  
Vol 42 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Yasuyuki Gondo ◽  
Yoshiko Shimonaka ◽  
Michio Senda ◽  
Masahiro Mishina ◽  
Hinako Toyama
Keyword(s):  
Positron Emission Tomography ◽  
Prefrontal Cortex ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission

Prefrontal cortex activity in people with schizophrenia and control subjects

1998 ◽  
Vol 172 (4) ◽  
pp. 316-323 ◽  
Author(s):  
Sean A. Spence ◽  
Steven R. Hirsch ◽  
David J. Brooks ◽  
Paul M. Grasby
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Symptomatic Improvement ◽  
Emission Tomography ◽  
Cortical Function ◽  
Control Subjects ◽  
Prefrontal Cortical ◽  
Positron Emission ◽  
Dorsolateral Prefrontal ◽  
And Control

BackgroundHypo-activation of the left dorsolateral prefrontal cortex is inconsistently found in neuroimaging studies of schizophrenia. As the left dorsolateral prefrontal cortex is involved in the generation of action, disordered function in this region may be implicated in schizophrenic symptomatology.MethodWe used H215O positron emission tomography to study dorsolateral prefrontal cortical function in men with schizophrenia (n=13) and male control subjects (n=6) performing joystick movements on two occasions, 4–6 weeks apart. The patients were initially in relapse. To clarify dorsolateral prefrontal cortical function we also scanned another group of control subjects (n=5) performing mouth movements.ResultsThe control subjects performing hand or mouth movements activated the left dorsolateral prefrontal cortex to a maximum when the movements were self-selected. The men with relapsed schizophrenia exhibited left dorsolateral prefrontal cortical hypo-activation, which remitted with symptomatic improvement.ConclusionsHypofrontality in these patients is a dynamic phenomenon across time, possibly related to current symptomatology. The most appropriate question about the presence of hypofrontality in schizophrenia may be when, rather than whether, it will occur.

The role of the human prefrontal cortex in working memory and attention — A study using positron emission tomography

NeuroImage ◽  
1996 ◽  
Vol 3 (3) ◽  
pp. S503 ◽  
Author(s):  
B.T. O'Sullivan ◽  
M.M. Large ◽  
B.L. Woodham ◽  
N.A. Barrett ◽  
G.L. Smith ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Working Memory ◽  
Prefrontal Cortex ◽  
Emission Tomography ◽  
Memory And Attention ◽  
Positron Emission

Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives

2018 ◽  
Vol 25 (26) ◽  
pp. 3096-3104 ◽  
Author(s):  
Daniele Mauro ◽  
Gaetano Barbagallo ◽  
Salvatore D`Angelo ◽  
Pasqualina Sannino ◽  
Saverio Naty ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Central Nervous System ◽  
Nervous System ◽  
Autoimmune Diseases ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Cns Involvement ◽  
Systemic Autoimmune Diseases ◽  
Positron Emission

In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography [PET]. The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography [CT] or magnetic resonance imaging[MRI] in order to improve spatial resolution. Early preclinical studies suggested that 18F–FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction. Neurological involvement is a distinct feature of various systemic autoimmune diseases, i.e. Systemic Lupus Erythematosus [SLE] or Behcet’s disease [BD]. Although MRI is largely considered the gold-standard imaging technique for the detection of Central Nervous System [CNS] involvement in these disorders. Several patients complain of neuropsychiatric symptoms [headache, epilepsy, anxiety or depression] in the absence of any significant MRI finding; in such patients the diagnosis relies mainly on clinical examination and often the role of the disease process versus iatrogenic or reactive forms is doubtful. The aim of this review is to explore the state-of-the-art for the role of PET imaging in CNS involvement in systemic rheumatic diseases. In addition, we explore the potential role of emerging radiopharmaceutical and their possible application in aiding the diagnosis of CNS involvement in systemic autoimmune diseases.

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