Acute Hyperglycemia and Hyperinsulinemia Enhance Vasodilatation in Type 1 Diabetes Mellitus without Increasing Capillary Permeability and Inducing Endothelial Dysfunction

2002 ◽  
Vol 63 (1) ◽  
pp. 1-9 ◽  
Author(s):  
P.H.N. Oomen ◽  
G.D. Kant ◽  
R.P.F. Dullaart ◽  
W.D. Reitsma ◽  
A.J. Smit
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Capillary Permeability ◽  
Acute Hyperglycemia

Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1DM): A real-time intravital microscopy study

2009 ◽  
Vol 42 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Anthony T.W. Cheung ◽  
M. Meighan (Smith) Tomic ◽  
Peter C.Y. Chen ◽  
Eric Miguelino ◽  
Chin-Shang Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Real Time ◽  
Intravital Microscopy ◽  
Microscopy Study

scholarly journals Assessing endothelial dysfunction in adolescents and young adults with type 1 diabetes mellitus using a non-invasive heat stimulus

2014 ◽  
Vol 16 (6) ◽  
pp. 434-440 ◽  
Author(s):  
Amy S. Shah ◽  
Zhiqian Gao ◽  
Lawrence M. Dolan ◽  
Dana Dabelea ◽  
Ralph B. D'Agostino ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Adolescents And Young Adults ◽  
Non Invasive ◽  
Heat Stimulus

scholarly journals Type 1 diabetes mellitus and celiac disease: endothelial dysfunction

2011 ◽  
Vol 51 (2) ◽  
pp. 333-333 ◽  
Author(s):  
Antonio Picarelli ◽  
Marco Di Tola ◽  
Tania D’Amico ◽  
Valeria Mercuri ◽  
Patrizia Gargiulo
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus

scholarly journals Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy

2009 ◽  
Vol 12 (1) ◽  
pp. 29-32 ◽  
Author(s):  
A A Afonin ◽  
M V Komkova ◽  
G A Galkina ◽  
N V Morozova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Griess Reagent ◽  
Disability Score ◽  
Peripheral Polyneuropathy ◽  
And Control

Aim. To measure endothelial factors (nitric oxide (NOx) metabolites, endothelin-1 (ET-1), and basic fibroblast growth factor (bFGF)) in children and adolescentswith diabetes mellitus (DM) during development of diabetic peripheral polyneuropathy (DPNP). Materials and methods. A total of 130 children and adolescents with diabetes mellitus were examined. Duration of DM varied from 3 months to 14 years. Thecontrol group comprised 20 children and adolescents without DM or neurologic pathology. Subjective manifestations of DPNP were assessed based on thedata of a standardized Neuropathy Symptom Score (NSS) questionnaire. Neuropathy Disability Score (NDS) questionnaire was used to monitor objectivechanges of DPNP. NOx metabolites were detected with Griess reagent (Aldrich Chemical Co, USA). Serum ET-1 and bFGF were measured using solid-phaseimmunoenzyme assay (DRG, USA) and CYTIMMINE (USA) kits respectively. Results. All children and adolescents with DM1 had lower NOx and bFGF levels than controls. ET-1 level in DM patients was 3.5 times that in controls. DMpatients with DPNP had more pronounced endothelial dysfunction than DM patients without DPNP and control subjects. Patients with hyperproduction ofNOx had DM for more than 10 years and their total NDS score was significantly higher than in two other groups. Conclusion. Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus progresses with the development of DPNP. Depletion of endothelialfunctional reserve is responsible for the unfavourable course of DPNP.

scholarly journals Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus

2021 ◽  
Vol 10 (21) ◽  
pp. 5065
Author(s):  
Karolina Nocuń-Wasilewska ◽  
Danuta Zwolińska ◽  
Agnieszka Zubkiewicz-Kucharska ◽  
Dorota Polak-Jonkisz
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Linear Correlations ◽  
Pai 1

Diabetic kidney disease belongs to the major complications of diabetes mellitus. Here, hyperglycaemia is a key metabolic factor that causes endothelial dysfunction and vascular changes within the renal glomerulus. The aim of the present study was to assess the function of the vascular endothelium in children with type 1 diabetes mellitus (type 1 diabetes) by measuring selected endothelial lesion markers in blood serum. The selected markers of endothelial lesions (sVCAM-1, sICAM-1, sE-SELECTIN, PAI-1, ADMA and RAGE) were assayed by the immunoenzymatic ELISA method. The study involved 66 patients (age: 5–18 years) with type 1 diabetes and 21 healthy controls (age: 5–16 years). In the type 1 diabetes patients, significantly higher concentrations of all of the assayed markers were observed compared to the healthy controls (p < 0.001). All of the evaluated markers positively correlated with the disease duration, the age, and BMI of the patients, while only PAI-1 and sE-SELECTIN were characteristic of linear correlations with the estimated glomerular filtration rate (eGFR). It can be concluded that endothelial inflammatory disease occurs in the early stages of type 1 diabetes mellitus in children. The correlations between PAI-1, sE-SELECTIN, and eGFR suggest an advantage of these markers over other markers of endothelial dysfunction as prognostic factors for kidney dysfunction in children with type 1 diabetes.

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