Influence of a New Monomeric Nonionic Radiographic Contrast Medium (Iobitridol-350 versus NaCl) on Cutaneous Microcirculation: Single-Center, Prospective, Randomized, Double-Blind Phase IV Study in Parallel Group Design

2000 ◽  
Vol 60 (3) ◽  
pp. 193-200 ◽  
Author(s):  
R. Bach ◽  
U. Gerk ◽  
C. Mrowietz ◽  
F. Jung
Keyword(s):  
Contrast Medium ◽  
Single Center ◽  
Double Blind ◽  
Group Design ◽  
Cutaneous Microcirculation ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Radiographic Contrast Medium ◽  
Radiographic Contrast ◽  
Phase Iv

A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

1991 ◽  
Vol 159 (3) ◽  
pp. 394-398 ◽  
Author(s):  
G. C. Dunbar ◽  
J. B. Cohn ◽  
L. F. Fabre ◽  
J. P. Feighner ◽  
R. R. Fieve ◽  
...  
Keyword(s):  
Side Effects ◽  
Beneficial Effect ◽  
Anxiety Symptoms ◽  
Drop Out ◽  
Antidepressant Effect ◽  
Double Blind ◽  
Group Design ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Antidepressant Efficacy

To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with imipramine. Paroxetine had a possible earlier antidepressant effect than imipramine, and a possible earlier beneficial effect on anxiety symptoms associated with depression.

New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorder

2005 ◽  
Vol 20 (2) ◽  
pp. 92-95 ◽  
Author(s):  
JR Calabrese ◽  
DJ Rapport ◽  
EA Youngstrom ◽  
K. Jackson ◽  
S. Bilali ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Unmet Need ◽  
Depressive Illness ◽  
Term Treatment ◽  
Rapid Cycling ◽  
Double Blind ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Long Term Treatment ◽  
Current Therapies

AbstractThe rapid cycling variant of bipolar disorder is defined as the occurrence of four periods of either manic or depressive illness within 12 months. Patients suffering from this variant of bipolar disorder have an unmet need for effective treatment. This review examines two major studies in an attempt to update understanding of the current therapies available to treat rapid cycling patients. The first trial compares lamotrigine versus placebo in 182 patients studied for 6 months. The second is a recently completed, 20-month trial comparing divalproate and lithium in 60 patients. Both trials had a double-blind, randomized parallel-group design. The data from the latter study indicate that there are no large differences in efficacy between lithium and divalproate in the long-term treatment of rapid cycling bipolar disorder. In addition, lamotrigine has the potential to complement the spectrum of lithium and divalproate through its greater efficacy for depressive symptoms.

A Clinical Study of Quazepam in Hospitalized Patients with Insomnia

1981 ◽  
Vol 9 (4) ◽  
pp. 288-291 ◽  
Author(s):  
Hans K Uhthoff ◽  
Jacques A Brunet ◽  
Anand Aggerwal ◽  
Raymond Varin
Keyword(s):  
Clinical Study ◽  
Sleep Quality ◽  
Quality Index ◽  
Adverse Reactions ◽  
Activity Index ◽  
Global Evaluation ◽  
Group Design ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Hypnotic Activity

The efficacy of quazepam (Sch-16134) 15 mg capsules as a hypnotic has been compared with that of placebo in a 9-day study, using a parallel-group design. The physician's global evaluation numerically favoured quazepam 63% (nineteen of thirty) over placebo 50% (fifteen of thirty). Furthermore, it demonstrated greater improvement in Hypnotic Activity Index and Sleep Quality Index from baseline scores, and caused no adverse reactions.

scholarly journals Intra-arterial and intravenous applications of Iosimenol 340 injection, a new non-ionic, dimeric, iso-osmolar radiographic contrast medium: phase 2 experience

2015 ◽  
Vol 56 (6) ◽  
pp. 702-708 ◽  
Author(s):  
Karoline Meurer ◽  
Michael Laniado ◽  
Norbert Hosten ◽  
Bettina Kelsch ◽  
Barry Hogstrom
Keyword(s):  
Contrast Medium ◽  
Phase 2 ◽  
Radiographic Contrast Medium ◽  
Radiographic Contrast

scholarly journals Improving Attitudes to Volunteering Among Older Adults: A Randomized Trial Approach

2019 ◽  
Vol 42 (2) ◽  
pp. 51-61 ◽  
Author(s):  
Michelle I. Jongenelis ◽  
Ben Jackson ◽  
Jeni Warburton ◽  
Robert U. Newton ◽  
Simone Pettigrew
Keyword(s):  
Older Adults ◽  
Social Connectedness ◽  
Healthy Aging ◽  
Social Needs ◽  
Volunteer Work ◽  
Group Design ◽  
Perceptions And Attitudes ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Negative Perceptions

Promoting engagement in formal volunteering represents a potential means of facilitating healthy aging. Given reluctance to participate in volunteering has been partially attributed to negative perceptions of various aspects of this activity, this study assessed whether trialing volunteering can improve perceptions among older people. Using a parallel-group design, Australians aged 60+ years ( n = 445) were randomly assigned to one of two conditions, one in which they were encouraged to trial volunteering and one in which they were asked to continue their usual activities. Perceptions and attitudes among those in the volunteering condition became significantly more favorable over 6 months relative to those in the control condition, with this change predicted by several aspects of the volunteering experience (e.g., acquisition of skills, increased social connectedness). Providing access to roles that cater to the learning and social needs of older adults appears to be important for improving attitudes toward engaging in volunteer work.

scholarly journals Nanotoxic Profiling of Novel Iron Oxide Nanoparticles Functionalized with Perchloric Acid and SiPEG as a Radiographic Contrast Medium

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Muhamad Idham Mohamed ◽  
Mohd Khairul Amran Mohammad ◽  
Hairil Rashmizal Abdul Razak ◽  
Khairunisak Abdul Razak ◽  
Wan Mazlina Md Saad
Keyword(s):  
Lipid Peroxidation ◽  
Iron Oxide ◽  
Contrast Medium ◽  
Iron Oxide Nanoparticles ◽  
Perchloric Acid ◽  
Metallic Nanoparticles ◽  
Oxide Nanoparticles ◽  
Radiographic Contrast Medium ◽  
Hematological Analysis ◽  
Radiographic Contrast

Emerging syntheses and findings of new metallic nanoparticles (MNPs) have become an important aspect in various fields including diagnostic imaging. To date, iodine has been utilized as a radiographic contrast medium. However, the raise concern of iodine threats on iodine-intolerance patient has led to search of new contrast media with lower toxic level. In this animal modeling study, 14 nm iron oxide nanoparticles (IONPs) with silane-polyethylene glycol (SiPEG) and perchloric acid have been assessed for toxicity level as compared to conventional iodine. The nanotoxicity of IONPs was evaluated in liver biochemistry, reactive oxygen species production (ROS), lipid peroxidation mechanism, and ultrastructural evaluation using transmission electron microscope (TEM). The hematological analysis and liver function test (LFT) revealed that most of the liver enzymes were significantly higher in iodine-administered group as compared to those in normal and IONPs groupsP<0.05. ROS production assay and lipid peroxidation indicator, malondialdehyde (MDA), also showed significant reductions in comparison with iodine groupP<0.05. TEM evaluation yielded the aberration of nucleus structure of iodine-administered group as compared to those in control and IONPs groups. This study has demonstrated the less toxic properties of IONPs and it may postulate that IONPs are safe to be applied as radiographic contrast medium.

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