The Relationship of Laser–Doppler Skin Blood Flow Measurements to the Cutaneous Microvascular Anatomy

1998 ◽  
Vol 55 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Marc S. Rendell ◽  
Mary F. Finnegan ◽  
James C. Healy ◽  
Anne Lind ◽  
Brian K. Milliken ◽  
...  
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Laser Doppler ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Relationship Of ◽  
The Relationship

Hybrid blood flow probe for simultaneous H2 clearance and laser-Doppler velocimetry

1987 ◽  
Vol 253 (4) ◽  
pp. G573-G581 ◽  
Author(s):  
G. R. DiResta ◽  
J. W. Kiel ◽  
G. L. Riedel ◽  
P. Kaplan ◽  
A. P. Shepherd
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Regional Blood Flow ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Flow Probe ◽  
Flow Measurements ◽  
Blood Flow Measurements ◽  
Light Guides ◽  
The Relationship

To perform two independent regional blood flow measurements in tissue volumes of similar dimensions, we designed a hybrid blood flow probe capable of measuring regional perfusion by both laser-Doppler velocimetry (LDV) and H2 clearance. The probe consisted of two fiber-optic light guides to conduct light between the surface of tissue of interest and a laser-Doppler blood flowmeter. Also contained within the probe were a platinum 25-microns H2-sensing electrode and a 125-microns H2-generating electrode. The probe can thus be used to measure local perfusion with H2 clearance. The H2 can either be inhaled or can be generated electrochemically at the locus of interest. Evaluation of the probe in the canine gastric mucosa indicated 1) that the relationship between mucosal flow measurements made simultaneously with H2 clearance and LDV was highly significant and linear and 2) that H2 clearance could potentially be used to calibrate the laser-Doppler blood flowmeter in absolute units. The methods of constructing the flow probes are discussed in detail.

Laser-Doppler measurement of skin blood flow: comparison with plethysmography

1984 ◽  
Vol 56 (3) ◽  
pp. 798-803 ◽  
Author(s):  
J. M. Johnson ◽  
W. F. Taylor ◽  
A. P. Shepherd ◽  
M. K. Park
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Response Pattern ◽  
Small Volume ◽  
Forearm Blood Flow ◽  
Laser Doppler ◽  
Whole Body ◽  
Doppler Measurement ◽  
The Relationship

We compared laser-Doppler velocimetry with plethysmographically determined changes in skin blood flow (SkBF) in five studies on four men. Increments in SkBF were induced by raising whole-body skin temperature to 39 degrees C for 50–70 min. We found laser-Doppler blood flow (LDF) to correlate well with total forearm blood flow (FBF) within each study (r = 0.94–0.98), but the relationship varied among studies. Thus the slopes for the LDF vs. FBF relationship varied from 40 to 122 mV X ml-1 X 100 ml X min. The value for LDF at zero FBF, extrapolated from the regression relationships, ranged from 246 to 599 mV above the value for LDF set with the probe on a stationary object. The value for LDF when blood flow to the arm was mechanically occluded ranged from 110 to 230 mV. In a second series, we measured the LDF values from six sites on forearms of each of four normothermic men. There was marked regional variation, with 1.8- to 5.7-fold ranges in LDF within a given subject. Values for LDF during occlusion of the forearm were more consistent within and between subjects. Thus LDF appears to provide a good indicator of the response pattern of SkBF from the region of illuminated skin. However, variability in the relationship to total SkBF (probably arising from variation in the number of perfused capillaries in the small volume of tissue) and uncertainties in the value of LDF at zero SkBF make quantitative use difficult.

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