scholarly journals Prolongation of Transgene Expression by Coexpression of Cytokine Response Modifier A in Rodent Liver after Adenoviral Gene Transfer

2002 ◽  
Vol 5 (3) ◽  
pp. 262-268 ◽  
Author(s):  
Xiao-Kang Li ◽  
Motomichi Kosuga ◽  
Keisuke Tokieda ◽  
Arihiko Kanaji ◽  
Yasuyuki Fukuhara ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Transgene Expression ◽  
Cytokine Response ◽  
Response Modifier ◽  
Adenoviral Gene Transfer

Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes

2001 ◽  
Vol 116 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Robert Dinser ◽  
Florian Kreppel ◽  
Frank Zaucke ◽  
Christoph Blank ◽  
Mats Paulsson ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Transgene Expression ◽  
Articular Chondrocytes ◽  
Adenoviral Gene Transfer

Intravitreal adenoviral gene transfer evokes an immune response in the retina that is directed against the heterologous lacZ transgene product but does not limit transgene expression

2001 ◽  
Vol 892 (2) ◽  
pp. 229-240 ◽  
Author(s):  
Stefan Isenmann ◽  
Stefan Engel ◽  
Sebastian Kügler ◽  
Claude Gravel ◽  
Michael Weller ◽  
...  
Keyword(s):  
Immune Response ◽  
Gene Transfer ◽  
Transgene Expression ◽  
Adenoviral Gene Transfer

scholarly journals Retrograde Transgene Expression via Neuron-Specific Lentiviral Vector Depends on Both Species and Input Projections

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1387
Author(s):  
Yukiko Otsuka ◽  
Hitomi Tsuge ◽  
Shiori Uezono ◽  
Soshi Tanabe ◽  
Maki Fujiwara ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Immune Responses ◽  
Envelope Glycoprotein ◽  
Transgene Expression ◽  
Histological Analysis ◽  
Lentiviral Vector ◽  
Cortical Input ◽  
Input System ◽  
Vesicular Stomatitis ◽  
Retrograde Gene Transfer

For achieving retrograde gene transfer, we have so far developed two types of lentiviral vectors pseudotyped with fusion envelope glycoprotein, termed HiRet vector and NeuRet vector, consisting of distinct combinations of rabies virus and vesicular stomatitis virus glycoproteins. In the present study, we compared the patterns of retrograde transgene expression for the HiRet vs. NeuRet vectors by testing the cortical input system. These vectors were injected into the motor cortex in rats, marmosets, and macaques, and the distributions of retrograde labels were investigated in the cortex and thalamus. Our histological analysis revealed that the NeuRet vector generally exhibits a higher efficiency of retrograde gene transfer than the HiRet vector, though its capacity of retrograde transgene expression in the macaque brain is unexpectedly low, especially in terms of the intracortical connections, as compared to the rat and marmoset brains. It was also demonstrated that the NeuRet but not the HiRet vector displays sufficiently high neuron specificity and causes no marked inflammatory/immune responses at the vector injection sites in the primate (marmoset and macaque) brains. The present results indicate that the retrograde transgene efficiency of the NeuRet vector varies depending not only on the species but also on the input projections.

Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication

2006 ◽  
Vol 18 (2) ◽  
pp. 167-174 ◽  
Author(s):  
J??rgen Siebler ◽  
Ulrike Protzer ◽  
Stefan Wirtz ◽  
Marcus Schuchmann ◽  
Thomas H??hler ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Gene Transfer ◽  
Hepatitis B ◽  
Virus Replication ◽  
Adenoviral Gene Transfer ◽  
B Virus

CFTR Transgene Expression in Primary ΔF508 Epithelial Cell Cultures From Human Nasal Polyps Following Gene Transfer With Cationic Phosphonolipids

2004 ◽  
Vol 26 (3) ◽  
pp. 193-206 ◽  
Author(s):  
Tristan Montier ◽  
Pascal Delépine ◽  
Rémi Marianowski ◽  
Karine Le Ny ◽  
Morgane Le Bris ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Epithelial Cell ◽  
Cell Cultures ◽  
Transgene Expression ◽  
Nasal Polyps ◽  
Epithelial Cell Cultures
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