scholarly journals Soluble Biodegradable Polymer-Based Cytokine Gene Delivery for Cancer Treatment

2000 ◽  
Vol 2 (2) ◽  
pp. 121-130 ◽  
Author(s):  
Anurag Maheshwari ◽  
Ram I. Mahato ◽  
John McGregor ◽  
Sang-oh Han ◽  
Wolfram E. Samlowski ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Treatment ◽  
Biodegradable Polymer ◽  
Cytokine Gene

Exosome as a Natural Gene Delivery Vector for Cancer Treatment

2020 ◽  
Vol 20 (11) ◽  
pp. 821-830
Author(s):  
Prasad Pofali ◽  
Adrita Mondal ◽  
Vaishali Londhe
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Intestinal Barrier ◽  
Gene Carrier ◽  
Gene Delivery Vector ◽  
Delivery Vector

Background: Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these conventional vectors. Exosomes are the vesicles of size 40-100 nm secreted from multivesicular bodies into the extracellular environment by most of the cell types in-vivo and in-vitro. As a natural nanocarrier, exosomes are immunologically inert, biocompatible, and can cross biological barriers like the blood-brain barrier, intestinal barrier, and placental barrier. Objective: This review focusses on the role of exosome as a carrier to efficiently deliver a gene for cancer treatment and diagnosis. The methods for loading of nucleic acids onto the exosomes, advantages of exosomes as a smart intercellular shuttle for gene delivery and therapeutic applications as a gene delivery vector for siRNA, miRNA and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and also the limitations of exosomes as a gene carrier are all reviewed in this article. Methods: Mostly, electroporation and chemical transfection are used to prepare gene loaded exosomes. Results: Exosome-mediated delivery is highly promising and advantageous in comparison to the current delivery methods for systemic gene therapy. Targeted exosomes, loaded with therapeutic nucleic acids, can efficiently promote the reduction of tumor proliferation without any adverse effects. Conclusion: In the near future, exosomes can become an efficient gene carrier for delivery and a biomarker for the diagnosis and treatment of cancer.

scholarly journals Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 940
Author(s):  
Chaojie Zhu ◽  
Zhiheng Ji ◽  
Junkai Ma ◽  
Zhijie Ding ◽  
Jie Shen ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Treatment ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Cancer Treatments ◽  
Recent Advances ◽  
Therapeutic Mechanisms ◽  
Bacterial Therapy ◽  
Targeting Ability ◽  
Drug And Gene Delivery

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.

Plasmid DNA microgels for cancer treatment through combination of chemotherapy and gene delivery

2014 ◽  
Vol 185 ◽  
pp. S35
Author(s):  
Diana Barata Costa ◽  
Artur Monteiro Valente ◽  
João Sampaio Queiroz
Keyword(s):  
Gene Delivery ◽  
Cancer Treatment ◽  
Plasmid Dna

Endothelial cell-based cytokine gene delivery inhibits 9L glioma growth in vivo

1996 ◽  
Vol 731 (1-2) ◽  
pp. 161-170 ◽  
Author(s):  
Myeong Nam ◽  
Peter Johnston ◽  
Bachchu Lal ◽  
Ravinder Indurti ◽  
Mary Ann Wilson ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Gene Delivery ◽  
Cytokine Gene ◽  
Glioma Growth ◽  
9L Glioma

scholarly journals Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma

2000 ◽  
Vol 97 (21) ◽  
pp. 11500-11504 ◽  
Author(s):  
D. Balicki ◽  
R. A. Reisfeld ◽  
U. Pertl ◽  
E. Beutler ◽  
H. N. Lode
Keyword(s):  
Gene Delivery ◽  
Histone H2a ◽  
Cytokine Gene ◽  
Murine Neuroblastoma

Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery

Lupus ◽  
1995 ◽  
Vol 4 (4) ◽  
pp. 286-292 ◽  
Author(s):  
E. Raz ◽  
J. Dudler ◽  
M. Lotz ◽  
S.M. Baird ◽  
C.C. Berry ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Delivery ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Cytokine Gene ◽  
Systemic Lupus ◽  
Murine Systemic Lupus Erythematosus
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