Analysis of Linkage Disequilibrium between Polymorphisms in the KCNJ9 Gene with Type 2 Diabetes Mellitus in Pima Indians

2001 ◽  
Vol 73 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Johanna K Wolford ◽  
Robert L Hanson ◽  
Sayuko Kobes ◽  
Clifton Bogardus ◽  
Michal Prochazka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Linkage Disequilibrium ◽  
Pima Indians

A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians

2003 ◽  
Vol 78 (2) ◽  
pp. 136-144 ◽  
Author(s):  
Johanna K Wolford ◽  
Jonathan D Gruber ◽  
Victoria M Ossowski ◽  
Barbora Vozarova ◽  
P Antonio Tataranni ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Promoter Polymorphism ◽  
Pima Indians ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Molecular characterization of the human PEA15 gene on 1q21–q22 and association with type 2 diabetes mellitus in Pima Indians

Gene ◽  
2000 ◽  
Vol 241 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Johanna K Wolford ◽  
Clifton Bogardus ◽  
Victoria Ossowski ◽  
Michal Prochazka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Molecular Characterization ◽  
Pima Indians

scholarly journals Glomerular Permselectivity at the Onset of Nephropathy in Type 2 Diabetes Mellitus

2000 ◽  
Vol 11 (11) ◽  
pp. 2095-2105
Author(s):  
KEVIN V. LEMLEY ◽  
KRISTINA BLOUCH ◽  
ISHA ABDULLAH ◽  
DEREK B. BOOTHROYD ◽  
PETER H. BENNETT ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pima Indians ◽  
Glomerular Injury ◽  
Control Subjects ◽  
Glomerular Barrier

Abstract. The development of microalbuminuria in individuals with type 2 diabetes mellitus is associated with a 10-fold increase in the risk of progression to overt nephropathy and eventual end-stage renal failure. The present study reports long-term (up to 8 yr) follow-up of 43 Pima Indians with type 2 diabetes detected on screening to have microalbuminuria. The natural history of albuminuria in these individuals included progression to overt proteinuria (urinary albumin excretion ≥ 300 mg/d) in half of the participants by 7 yr of follow-up. The size selectivity of the glomerular barrier was also investigated using dextran sieving and pore theory. Whereas a comparison group of macroalbuminuric Pima Indians had an excess of large pores that served as a macromolecular “shunt,” individuals with microalbuminuria had a shunt size no different from long-term diabetic, normoalbuminuric control subjects. An abrupt transition from little or no relationship to a highly significant and positive relationship between increasing albuminuria and shunt size occurred at an albumin-to-creatinine ratio of approximately 3000 mg/g. Shunt size in macroalbuminuric individuals correlated with the extent of foot process broadening. Podocyte foot processes in microalbuminuric participants were not different from those in control subjects. In conclusion, although microalbuminuria in type 2 diabetic Pima Indians often heralds progressive glomerular injury, it is not the result of defects in the size permselectivity of the glomerular barrier but rather of changes in either glomerular charge selectivity or tubular handling of filtered proteins or of a combination of these two factors.

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