Signal Transduction Pathways in Hyperoxia-Induced Lung Cell Death

2000 ◽  
Vol 71 (1-2) ◽  
pp. 359-370 ◽  
Author(s):  
Lin L. Mantell ◽  
Patty J. Lee
Keyword(s):  
Signal Transduction ◽  
Cell Death ◽  
Signal Transduction Pathways

Signal-regulated oxidation of proteins via MICAL

2020 ◽  
Vol 48 (2) ◽  
pp. 613-620
Author(s):  
Clara Ortegón Salas ◽  
Katharina Schneider ◽  
Christopher Horst Lillig ◽  
Manuela Gellert
Keyword(s):  
Signal Transduction ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Redox Regulation ◽  
Signal Transduction Pathways ◽  
Cellular Functions ◽  
Intracellular Signals ◽  
Amino Acid Side Chains ◽  
Specific Receptors ◽  
Sulfur Containing

Processing of and responding to various signals is an essential cellular function that influences survival, homeostasis, development, and cell death. Extra- or intracellular signals are perceived via specific receptors and transduced in a particular signalling pathway that results in a precise response. Reversible post-translational redox modifications of cysteinyl and methionyl residues have been characterised in countless signal transduction pathways. Due to the low reactivity of most sulfur-containing amino acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail before, the discovery and characterisation of MICAL proteins evinced the first examples of specific oxidases in signal transduction. This article provides an overview of the functions of MICAL proteins in the redox regulation of cellular functions.

Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway

Blood ◽  
2005 ◽  
Vol 105 (3) ◽  
pp. 1214-1221 ◽  
Author(s):  
Thomas Powles ◽  
Robert te Poele ◽  
Jonathan Shamash ◽  
Tracy Chaplin ◽  
David Propper ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Death ◽  
Cell Lines ◽  
Leukemic Cell ◽  
Cytotoxic Agents ◽  
Complex Signal ◽  
Signal Transduction Pathways ◽  
Potent Inducer ◽  
Leukemic Cell Lines

Abstract Δ9-Tetrahydrocannabinol (THC) is the active metabolite of cannabis. THC causes cell death in vitro through the activation of complex signal transduction pathways. However, the role that the cannabinoid 1 and 2 receptors (CB1-R and CB2-R) play in this process is less clear. We therefore investigated the role of the CB-Rs in mediating apoptosis in 3 leukemic cell lines and performed microarray and immunoblot analyses to establish further the mechanism of cell death. We developed a novel flow cytometric technique of measuring the expression of functional receptors and used combinations of selective CB1-R and CB2-R antagonists and agonists to determine their individual roles in this process. We have shown that THC is a potent inducer of apoptosis, even at 1 × IC50 (inhibitory concentration 50%) concentrations and as early as 6 hours after exposure to the drug. These effects were seen in leukemic cell lines (CEM, HEL-92, and HL60) as well as in peripheral blood mononuclear cells. Additionally, THC did not appear to act synergistically with cytotoxic agents such as cisplatin. One of the most intriguing findings was that THC-induced cell death was preceded by significant changes in the expression of genes involved in the mitogen-activated protein kinase (MAPK) signal transduction pathways. Both apoptosis and gene expression changes were altered independent of p53 and the CB-Rs.

scholarly journals Signal transduction pathways that regulate cell survival and cell death

Oncogene ◽  
1998 ◽  
Vol 17 (25) ◽  
pp. 3207-3213 ◽  
Author(s):  
Tomislav Dragovich ◽  
Charles M Rudin ◽  
Craig B Thompson
Keyword(s):  
Signal Transduction ◽  
Cell Death ◽  
Cell Survival ◽  
Signal Transduction Pathways

scholarly journals Role of a Small Molecule in the Modulation of Cell Death Signal Transduction Pathways

2018 ◽  
Vol 4 (12) ◽  
pp. 1746-1754 ◽  
Author(s):  
Stella Hartmann ◽  
David J. Nusbaum ◽  
Kevin Kim ◽  
Saleem Alameh ◽  
Chi-Lee C. Ho ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Death ◽  
Small Molecule ◽  
Signal Transduction Pathways

scholarly journals Hematopoietic Factor Erythropoietin Fosters Neuroprotection through Novel Signal Transduction Cascades

2002 ◽  
Vol 22 (5) ◽  
pp. 503-514 ◽  
Author(s):  
Zhao Zhong Chong ◽  
Jing-Qiong Kang ◽  
Kenneth Maiese
Keyword(s):  
Signal Transduction ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Molecular Mechanisms ◽  
Cysteine Proteases ◽  
Cellular Membrane ◽  
Nuclear Factor Κb ◽  
Erythropoietin Receptor ◽  
Signal Transduction Pathways ◽  
Tyrosine Kinase 2

In addition to promoting the survival, proliferation, and differentiation of immature erythroid cells, erythropoietin and the erythropoietin receptor have recently been shown to modulate cellular signal transduction pathways that extend beyond the erythropoietic function of erythropoietin. In particular, erythropoietin has been linked to the prevention of programmed cell death in neuronal systems. Although this work is intriguing, the underlying molecular mechanisms that serve to mediate neuroprotection by erythropoietin are not well understood. Further analysis illustrates that erythropoietin modulates two distinct components of programmed cell death that involve the degradation of DNA and the externalization of cellular membrane phosphatidylserine residues. Initiation of the cascades that modulate protection by erythropoietin and its receptor may begin with the activation of the Janus tyrosine kinase 2 protein. Subsequent downstream mechanisms appear to lead to the activation of multiple signal transduction pathways that include transcription factor STAT5 (signal transducers and activators of transcription), Bcl-2, protein kinase B, cysteine proteases, mitogen-activated protein kinases, proteintyrosine phosphatases, and nuclear factor-κB. New knowledge of the cellular pathways regulated by erythropoietin in neuronal environments will potentially solidify the development and initiation of therapeutic strategies against nervous system disorders.

scholarly journals Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review

2018 ◽  
Vol 10 (9) ◽  
pp. 244-259 ◽  
Author(s):  
Pandurangan Ashokkumar ◽  
Thomas Divya ◽  
Kalaivani Kumar ◽  
Vadivel Dineshbabu ◽  
Bakthavatchalam Velavan ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Death ◽  
Colorectal Carcinogenesis ◽  
Signal Transduction Pathways
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