Homer-Dependent Cell Surface Expression of Metabotropic Glutamate Receptor Type 5 in Neurons

2002 ◽  
Vol 20 (2) ◽  
pp. 323-329 ◽  
Author(s):  
Fabrice Ango ◽  
David Robbe ◽  
Jian Cheng Tu ◽  
Bo Xiao ◽  
Paul F. Worley ◽  
...  
Keyword(s):  
Cell Surface ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Surface Expression ◽  
Receptor Type ◽  
Cell Surface Expression ◽  
Metabotropic Glutamate ◽  
Dependent Cell

scholarly journals Metabotropic Glutamate Receptor Trafficking and its Role in Drug-Induced Neurobehavioral Plasticity

2021 ◽  
pp. 1-16
Author(s):  
Peter U. Hámor ◽  
Marek Schwendt
Keyword(s):  
Glutamate Receptor ◽  
Membrane Trafficking ◽  
Metabotropic Glutamate Receptor ◽  
Neuropsychiatric Disorders ◽  
Surface Expression ◽  
Receptor Trafficking ◽  
Fine Tuning ◽  
Cell Surface Expression ◽  
Metabotropic Glutamate ◽  
Glutamate Receptor Trafficking

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that guides developmental and experience-dependent changes in many cellular substrates and brain circuits, through the process collectively referred to as neurobehavioral plasticity. Regulation of cell surface expression and membrane trafficking of glutamate receptors represents an important mechanism that assures optimal excitatory transmission, and at the same time, also allows for fine-tuning neuronal responses to glutamate. On the other hand, there is growing evidence implicating dysregulated glutamate receptor trafficking in the pathophysiology of several neuropsychiatric disorders. This review provides up-to-date information on the molecular determinants regulating trafficking and surface expression of metabotropic glutamate (mGlu) receptors in the rodent and human brain and discusses the role of mGluR trafficking in maladaptive synaptic plasticity produced by addictive drugs. As substantial evidence links glutamatergic dysfunction to the progression and the severity of drug addiction, advances in our understanding of mGluR trafficking may provide opportunities for the development of novel pharmacotherapies of addiction and other neuropsychiatric disorders.

Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1

2010 ◽  
Vol 37 (5) ◽  
pp. 615-624 ◽  
Author(s):  
Kazuhiko Yanamoto ◽  
Fujiko Konno ◽  
Chika Odawara ◽  
Tomoteru Yamasaki ◽  
Kazunori Kawamura ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Type ◽  
Metabotropic Glutamate
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