Growth Cone Steering by Receptor Tyrosine Phosphatase δ Defines a Distinct Class of Guidance Cue

2000 ◽  
Vol 16 (5) ◽  
pp. 686-695 ◽  
Author(s):  
Qi Lun Sun ◽  
Jun Wang ◽  
Richard J. Bookman ◽  
John L. Bixby
Keyword(s):  
Growth Cone ◽  
Tyrosine Phosphatase ◽  
Distinct Class ◽  
Guidance Cue ◽  
Receptor Tyrosine Phosphatase

scholarly journals The Receptor Tyrosine Phosphatase Crypα Promotes Intraretinal Axon Growth

1999 ◽  
Vol 147 (2) ◽  
pp. 375-388 ◽  
Author(s):  
Matthias M. Ledig ◽  
Fawaz Haj ◽  
John L. Bixby ◽  
Andrew W. Stoker ◽  
Bernhard K. Mueller
Keyword(s):  
Ganglion Cell ◽  
Growth Cone ◽  
Close Contact ◽  
Tyrosine Phosphatase ◽  
Axon Growth ◽  
Basal Membrane ◽  
Retinal Growth ◽  
Excellent Growth ◽  
Receptor Tyrosine Phosphatase ◽  
Retinal Axon

Retinal ganglion cell axons grow towards the optic fissure in close contact with the basal membrane, an excellent growth substratum. One of the ligands of receptor tyrosine phosphatase CRYPα is located on the retinal and tectal basal membranes. To analyze the role of this RPTP and its ligand in intraretinal growth and guidance of ganglion cell axons, we disrupted ligand- receptor interactions on the retinal basal membrane in culture. Antibodies against CRYPα strongly reduced retinal axon growth on the basal membrane, and induced a dramatic change in morphology of retinal growth cones, reducing the size of growth cone lamellipodia. A similar effect was observed by blocking the ligand with a CRYPα ectodomain fusion protein. These effects did not occur, or were much reduced, when axons were grown either on laminin-1, on matrigel or on basal membranes with glial endfeet removed. This indicates that a ligand for CRYPα is located on glial endfeet. These results show for the first time in vertebrates that the interaction of a receptor tyrosine phosphatase with its ligand is crucial not only for promotion of retinal axon growth but also for maintenance of retinal growth cone lamellipodia on basal membranes.

scholarly journals Dynamic Microtubule Ends Are Required for Growth Cone Turning to Avoid an Inhibitory Guidance Cue

1997 ◽  
Vol 17 (9) ◽  
pp. 3085-3095 ◽  
Author(s):  
Jean F. Challacombe ◽  
Diane M. Snow ◽  
Paul C. Letourneau
Keyword(s):  
Growth Cone ◽  
Guidance Cue ◽  
Dynamic Microtubule

Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signaling

2010 ◽  
Vol 22 (11) ◽  
pp. 1626-1633 ◽  
Author(s):  
Mélanie J. Chagnon ◽  
Chia-Lun Wu ◽  
Takanobu Nakazawa ◽  
Tadashi Yamamoto ◽  
Masaharu Noda ◽  
...  
Keyword(s):  
Tyrosine Phosphatase ◽  
Receptor Tyrosine Phosphatase
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