Advanced Glycation End Products Induce Blood–Retinal Barrier Dysfunction in Normoglycemic Rats

2000 ◽  
Vol 3 (6) ◽  
pp. 380-388 ◽  
Author(s):  
Alan W. Stitt ◽  
Tisha Bhaduri ◽  
C.B.Tara McMullen ◽  
Thomas A. Gardiner ◽  
Desmond B. Archer
Keyword(s):  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Barrier Dysfunction ◽  
Blood Retinal Barrier ◽  
Glycation End Products ◽  
End Products

scholarly journals Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy

2018 ◽  
Vol 48 (2) ◽  
pp. 705-717 ◽  
Author(s):  
Jing Xu ◽  
Lin-Jiang Chen ◽  
Jian Yu ◽  
Han-Jing Wang ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Advanced Glycation End Products ◽  
Intracellular Signaling ◽  
Vascular Inflammation ◽  
Advanced Glycation ◽  
Blood Retinal Barrier ◽  
Glycation End Products ◽  
End Products ◽  
And Function ◽  
Medical Burden

Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an important role in the pathogenesis of DR. AGEs can exert their deleterious effects by acting directly to induce aberrant crosslinking of extracellular matrix proteins, to increase vascular stiffness, altering vascular structure and function. Moreover, AGEs binding to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal barrier (BRB), the end result of all these events is damage to the neural and vascular components of the retina. Elucidation of AGE-induced mechanisms will help in the understanding of the complex cellular and molecular pathogenesis associated with DR. Novel anti-AGEs agents or AGE crosslink “breakers” are being investigated, it is hoped that in next few years, some of these promising therapies will be successfully applied in clinical context, aiming to reduce the major economical and medical burden caused by DR.

Sign in / Sign up

Export Citation Format

Share Document