p53-Independent Down-Regulation of Mdm2 in Human Cancer Cells Treated with Adriamycin

2000 ◽  
Vol 3 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Yongxian Ma ◽  
Renqi Yuan ◽  
Qinghui Meng ◽  
Itzhak D. Goldberg ◽  
Eliot M. Rosen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Human Cancer Cells

scholarly journals Down-regulation of the Tumor Suppressor C-terminal Src Kinase (Csk)-binding Protein (Cbp)/PAG1 Is Mediated by Epigenetic Histone Modifications via the Mitogen-activated Protein Kinase (MAPK)/Phosphatidylinositol 3-Kinase (PI3K) Pathway

2011 ◽  
Vol 286 (18) ◽  
pp. 15698-15706 ◽  
Author(s):  
Kei Suzuki ◽  
Chitose Oneyama ◽  
Hironobu Kimura ◽  
Shoji Tajima ◽  
Masato Okada
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Histone Modifications ◽  
Human Cancer ◽  
Methylation Status ◽  
Adaptor Protein ◽  
Pi3k Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Down Regulation ◽  
Human Cancer Cells

The transmembrane adaptor protein Cbp (or PAG1) functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src. The expression of Cbp is down-regulated in Src-transformed cells and in various human cancer cells, suggesting a potential role for Cbp as a tumor suppressor. However, the mechanisms underlying the down-regulation of Cbp remain unknown. The present study shows that Cbp expression is down-regulated by epigenetic histone modifications via the MAPK/PI3K pathway. In mouse embryonic fibroblasts, transformation by oncogenic Src and Ras induced a marked down-regulation of Cbp expression. The levels of Cbp expression were inversely correlated with the activity of MEK and Akt, and Cbp down-regulation was suppressed by inhibiting MEK and PI3K. Src transformation did not affect the stability of Cbp mRNA, the transcriptional activity of the cbp promoter, or the DNA methylation status of the cbp promoter CpG islands. However, Cbp expression was restored by treatment with histone deacetylase (HDAC) inhibitors and by siRNA-mediated knockdown of HDAC1/2. Src transformation significantly decreased the acetylation levels of histone H4 and increased the trimethylation levels of histone H3 lysine 27 in the cbp promoter. EGF-induced Cbp down-regulation was also suppressed by inhibiting MEK and HDAC. Furthermore, the inhibition of MEK or HDAC restored Cbp expression in human cancer cells harboring Cbp down-regulation through promoter hypomethylation. These findings suggest that Cbp down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK/PI3K pathways in a subset of cancer cells.

scholarly journals Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1

Oncotarget ◽  
2015 ◽  
Vol 6 (34) ◽  
pp. 36202-36218 ◽  
Author(s):  
Hak-Bong Kim ◽  
Su-Hoon Lee ◽  
Jee-Hyun Um ◽  
Won Keun Oh ◽  
Dong-Wan Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Multidrug Resistant ◽  
Hsp90 Inhibitors ◽  
Down Regulation ◽  
Human Cancer Cells

p53 Inhibits Adriamycin-Induced Down-Regulation of Cyclin D1 Expression in Human Cancer Cells

2002 ◽  
Vol 290 (3) ◽  
pp. 1101-1107 ◽  
Author(s):  
Jianghua Shao ◽  
Fuminori Teraishi ◽  
Koh Katsuda ◽  
Noriaki Tanaka ◽  
Toshiyoshi Fujiwara
Keyword(s):  
Cyclin D1 ◽  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Human Cancer Cells

scholarly journals Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28

2011 ◽  
Vol 40 (9) ◽  
pp. 3856-3869 ◽  
Author(s):  
Chae Won Kim ◽  
Mai-Tram Vo ◽  
Hong Kyeung Kim ◽  
Hyun Hee Lee ◽  
Nal Ae Yoon ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Over Expression ◽  
Human Cancer Cells

Mechanisms involved in down-regulation of glutathione s-transferases alpha in human cancer cells

1995 ◽  
Vol 121 (S1) ◽  
pp. A18-A18
Author(s):  
W. A. Schultz ◽  
P. Eickelmann ◽  
A. Clairmont ◽  
T. Ebert ◽  
F. Morel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Human Cancer Cells ◽  
Glutathione S Transferases

scholarly journals Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Mohammad Hassan Naseri ◽  
Majid Mahdavi ◽  
Jamshid Davoodi ◽  
Saeed Hesami Tackallou ◽  
Mahdi Goudarzvand ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Human Cancer Cells

scholarly journals Selective recognition of c-myc promoter G-quadruplex and down-regulation of oncogene c-myc transcription in human cancer cells by 3,8a-disubstituted indolizinone

RSC Advances ◽  
2017 ◽  
Vol 7 (82) ◽  
pp. 51965-51969 ◽  
Author(s):  
Fengmin Yang ◽  
Xin Sun ◽  
Lixia Wang ◽  
Qian Li ◽  
Aijiao Guan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Selective Recognition ◽  
Down Regulation ◽  
Human Cancer Cells ◽  
G Quadruplex

Indolizinone could selectively recognize c-myc promoter G-quadruplex.

scholarly journals Down-regulation of Survivin enhances sensitivity to BPR0L075 in human cancer cells via caspase-independent mechanisms

2008 ◽  
Author(s):  
Chun Hei Antonio Cheung ◽  
Ching-Chuan Kuo ◽  
Chi-Yen Chang ◽  
Mohane Selvaraj Coumar ◽  
Hsing-Pang Hsieh ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Human Cancer Cells

scholarly journals Down-regulation of LAPTM5 in human cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (19) ◽  
pp. 28320-28328 ◽  
Author(s):  
Michelle Nuylan ◽  
Tatsuyuki Kawano ◽  
Johji Inazawa ◽  
Jun Inoue
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Down Regulation ◽  
Human Cancer Cells
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