Subacute Sepsis Impairs Vascular Smooth Muscle Contractile Machinery and Alters Vasoconstrictor and Dilator Mechanisms

1999 ◽  
Vol 83 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Shaun A. Price ◽  
David A. Spain ◽  
Mark A. Wilson ◽  
Patrick D. Harris ◽  
R.Neal Garrison
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contractile

Vascular Smooth Muscle Contractile Function Is Impaired during Early and Late Stages of Sepsis

1994 ◽  
Vol 56 (6) ◽  
pp. 556-561 ◽  
Author(s):  
Samuel H. Wurster ◽  
Ping Wang ◽  
Richard E. Dean ◽  
Irshad H. Chaudry
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Contractile Function ◽  
Late Stages ◽  
Muscle Contractile

scholarly journals Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries

2018 ◽  
Vol 9 ◽  
Author(s):  
John W. Seawright ◽  
Harini Sreenivasappa ◽  
Holly C. Gibbs ◽  
Samuel Padgham ◽  
Song Y. Shin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Contractile Function ◽  
Feed Arteries ◽  
Muscle Contractile ◽  
Skeletal Muscle Feed Arteries

Glycogen metabolism during tension generation and maintenance in vascular smooth muscle

1989 ◽  
Vol 257 (4) ◽  
pp. C736-C742 ◽  
Author(s):  
R. M. Lynch ◽  
C. P. Kuettner ◽  
R. J. Paul
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Glycogen Phosphorylase ◽  
Glycogen Metabolism ◽  
Metabolic Intermediates ◽  
Active Contraction ◽  
Glycogen Utilization ◽  
Tension Generation ◽  
Muscle Contractile ◽  
Porcine Carotid Artery

To study the regulation of glycogen utilization in vascular smooth muscle, we measured the content of glycogen and glucose 6-phosphate and the activity of the glycogen phosphorylase and glycogen debrancher enzymes in porcine carotid artery. During active contraction, the rates of glycogen phosphorylase and glycogenolysis were as high as expected. Despite this, glycogen content did not decrease to less than approximately 50% of control levels even after sustained contractions. The activity of glycogen debrancher enzyme was found to be limiting glycogen utilization at this point. Although glycogenolysis is closely coordinated with increases in oxidative metabolism concomitant with active contraction, the maximal level of tension obtained after stimulation was not substantially reduced under conditions where glycogen debrancher enzyme was limiting glycogen utilization. On the other hand, the rate of tension generation was increased in these tissues. Thus glycogen utilization is not necessary for maximal force generation per se, but may influence other muscle contractile properties. Finally, during steady-state tension maintenance, glycogen utilization is likely to be regulated by the intracellular concentrations of metabolic intermediates (glucose, glucose 6-phosphate), as it is in skeletal muscle.

Sign in / Sign up

Export Citation Format

Share Document