Cytokine Suppressive Agent Improves Survival Rate in Rats with Acute Pancreatitis of Closed Duodenal Loop

1999 ◽  
Vol 81 (2) ◽  
pp. 224-229 ◽  
Author(s):  
Tetsuya Hirano
Keyword(s):  
Acute Pancreatitis ◽  
Survival Rate ◽  
Closed Duodenal Loop

scholarly journals Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Hang Zhao ◽  
Zhiying He ◽  
Dandan Huang ◽  
Jun Gao ◽  
Yanfang Gong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Acute Pancreatitis ◽  
Mesenchymal Stem Cells ◽  
Survival Rate ◽  
Severe Acute Pancreatitis ◽  
Control Group ◽  
Therapeutic Effects ◽  
Isolation And Characterization ◽  
Marrow Mesenchymal Stem Cells

Background & Aims. Severe acute pancreatitis (SAP) remains a high-mortality disease. Bone marrow (BM) mesenchymal stem cells (MSCs) have been demonstrated to have plasticity of transdifferentiation and to have immunomodulatory functions. In the present study, we assessed the roles of MSCs in SAP and the therapeutic effects of MSC on SAP after transplantation.Methods. A pancreatitis rat model was induced by the injection of taurocholic acid (TCA) into the pancreatic duct. After isolation and characterization of MSC from BM, MSC transplantation was conducted 24 hrs after SAP induction by tail vein injection. The survival rate was observed and MSCs were traced after transplantation. The expression of TNF-αand IL-1βmRNA in the transplantation group was also analyzed.Results. The survival rate of the transplantation group was significantly higher compared to the control group (p<0.05). Infused MSCs were detected in the pancreas and BM 3 days after transplantation. The expression of TNF-αand IL-1βmRNA in the transplantation group was significantly lower than in the control group in both the pancreas and the lungs (p<0.05).Conclusions. MSC transplantation could improve the prognosis of SAP rats. Engrafted MSCs have the capacity of homing, migration, and planting during the treatment of SAP.

Biphasic Effect of Prostaglandin E1 on the Severity of Acute Pancreatitis Induced by a Closed Duodenal Loop in Rats

Pancreas ◽  
1996 ◽  
Vol 12 (2) ◽  
pp. 159-164 ◽  
Author(s):  
J. Pozsár ◽  
Z. Berger ◽  
K. Simon ◽  
A. Kovácsai ◽  
E. Marosi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Prostaglandin E1 ◽  
Biphasic Effect ◽  
Closed Duodenal Loop

scholarly journals MODIFICATION OF THE PFEFFER PANCREONECROSIS MODEL FOR ASSESSING PANCREATIC SECRETION IN THE ACUTE PERIOD OF DISEASE

2021 ◽  
pp. 42-47
Author(s):  
A.V. Borodach ◽  
◽  
N.I. Zakharov ◽  
Keyword(s):  
Experimental Study ◽  
Acute Pancreatitis ◽  
Pancreatic Secretion ◽  
Wistar Rats ◽  
Amylase Level ◽  
Exocrine Pancreatic Secretion ◽  
Acute Period ◽  
Closed Duodenal Loop

A preliminary experimental study: Measurement of exocrine pancreatic secretion was performed on Wistar rats after an induction of acute pancreatitis by ‘closed duodenal loop’ (CDL) method (total number of animals = 39). After 24 hrs duration of AP the CDL content was evacuated by syringe and tested for amylase level (IU/ml). A near normal output remained in most animals (1987,35 ± 558,26, n = 12); moderately decreased output was 264,67 ± 162,74 (n = 9), and cessation of the output in n = 3 (0,6 ± 0,3) (q < 0,01 for each group). So, in our series the exocrine pancreatic output was found diverging largely with a normal secretion prevailing. Further study is warranted for some conclusive results to obtain.

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