Activation of Human Somatostatin Receptor Type 2 Causes Inhibition of Cell Growth in Transfected HEK293 but Not in Transfected CHO Cells

1997 ◽  
Vol 71 (1) ◽  
pp. 13-18 ◽  
Author(s):  
J. Ren ◽  
G. Bell ◽  
D.H. Coy ◽  
F.C. Brunicardi
Keyword(s):  
Cell Growth ◽  
Cho Cells ◽  
Somatostatin Receptor ◽  
Receptor Type

scholarly journals Cell Growth Inhibition and Functioning of Human Somatostatin Receptor Type 2 Are Modulated by Receptor Heterodimerization

2008 ◽  
Vol 22 (10) ◽  
pp. 2278-2292 ◽  
Author(s):  
Michael Grant ◽  
Haydar Alturaihi ◽  
Philippe Jaquet ◽  
Brian Collier ◽  
Ujendra Ujendra
Keyword(s):  
Cell Growth ◽  
Growth Inhibition ◽  
Somatostatin Receptor ◽  
Receptor Type ◽  
Cell Growth Inhibition

scholarly journals Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2

2006 ◽  
Vol 13 (3) ◽  
pp. 955-962 ◽  
Author(s):  
E Ferrante ◽  
C Pellegrini ◽  
S Bondioni ◽  
E Peverelli ◽  
M Locatelli ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cultured Cells ◽  
Somatostatin Receptor ◽  
Hormone Secretion ◽  
Somatostatin Analogs ◽  
Receptor Type ◽  
Apoptotic Activity ◽  
Long Acting ◽  
Induced Apoptosis

Somatostatin analogs currently used in the treatment of acromegaly and other neuroendocrine tumors inhibit hormone secretion and cell proliferation by binding to somatostatin receptor type (SST) 2 and 5. The antiproliferative pathways coupled to these receptors have been only partially characterized. The aim of this study was to evaluate the effect of octreotide and super selective SST2 (BIM23120) and SST5 (BIM23206) analogs on apoptotic activity and apoptotic gene expression in human somatotroph tumor cells. Eight somatotroph tumors expressing similar levels of SST2 and SST5 evaluated by real-time PCR and western blot analyses were included in the study. In cultured cells obtained from these tumors, octreotide induced a dose-dependent increase of caspase-3 activity (160 ± 20% vs basal at 10 nM) and cleaved cytokeratin 18 levels (172 ± 25% vs basal) at concentrations higher than 0.1 nM. This effect was due to SST2 activation since BIM23120 elicited comparable responses, while BIM23206 was ineffective. BIM23120-stimulated apoptosis was dependent on phosphatases, since it was abrogated by the inhibitor orthovanadate, and independent from the induction of apoptosis-related genes, such as p53, p63, p73, Bcl-2, Bax, BID, BIK, TNFSF8, and FADD. In somatotroph tumors, both BIM23120 and BIM2306 caused growth arrest as indicated by the increase in p27 and decrease in cyclin D1 expression. In conclusion, the present study showed that octreotide-induced apoptosis in human somatotroph tumor cells by activating SST2. This effect, together with the cytostatic action exerted by both SST2 and SST5 analogs, might account for the tumor shrinkage observed in acromegalic patients treated with long-acting somatostatin analogs.

scholarly journals N-glycosylation of somatostatin receptor type 2 protects rats from acute pancreatitis

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ming Huang ◽  
Min-Min Chen ◽  
Dong Han ◽  
Wei Chen ◽  
Feng Xu
Keyword(s):  
Acute Pancreatitis ◽  
Somatostatin Receptor ◽  
Receptor Type

Somatostatin receptor type 2 mediated suppression of Helicobacter pylori proliferation in vitro

1998 ◽  
Vol 114 ◽  
pp. A1193
Author(s):  
K. Yamashita ◽  
H. Kaneko ◽  
T. Konagaya ◽  
S. Yamamoto ◽  
K. Kusugami ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Somatostatin Receptor ◽  
Receptor Type ◽  
Proliferation In Vitro

scholarly journals 177Lu-DOTA-EB-TATE, A Radiolabeled Analog of Somatostatin Receptor Type 2, for the Imaging and Treatment of Thyroid Cancer

2020 ◽  
pp. clincanres.3453.2020
Author(s):  
Shilpa Thakur ◽  
Brianna Daley ◽  
Corina Millo ◽  
Craig Cochran ◽  
Orit Jacobson ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Somatostatin Receptor ◽  
Receptor Type

Suppression of ANP secretion by somatostatin through somatostatin receptor type 2

Peptides ◽  
2011 ◽  
Vol 32 (6) ◽  
pp. 1179-1186 ◽  
Author(s):  
Shan Gao ◽  
Young-bin Oh ◽  
Amin Shah ◽  
Woo Hyun Park ◽  
Suhn Hee Kim
Keyword(s):  
Somatostatin Receptor ◽  
Receptor Type

scholarly journals Amelioration of Hypoglycemia Via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats

Diabetes ◽  
2013 ◽  
Vol 62 (7) ◽  
pp. 2215-2222 ◽  
Author(s):  
J. T. Y. Yue ◽  
M. C. Riddell ◽  
E. Burdett ◽  
D. H. Coy ◽  
S. Efendic ◽  
...  
Keyword(s):  
Somatostatin Receptor ◽  
Diabetic Rats ◽  
Receptor Type

Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas

2000 ◽  
Vol 52 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Stephan Petersenn ◽  
Maria Heyens ◽  
Dieter K. Lüdecke ◽  
Frank U. Beil ◽  
Heinrich M. Schulte
Keyword(s):  
Somatostatin Receptor ◽  
Receptor Type
Sign in / Sign up

Export Citation Format

Share Document