Identification of Altered Gene Expression in Skeletal Muscle during Sepsis Using Differential Display

1996 ◽  
Vol 64 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Gregory M. Tiao ◽  
Karen Hudson ◽  
Michael A. Lieberman ◽  
Josef E. Fischer ◽  
Per-Olof Hasselgren
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Differential Display ◽  
Altered Gene Expression ◽  
Altered Gene

scholarly journals Cataloging altered gene expression in young and senescent cells using enhanced differential display

1995 ◽  
Vol 23 (16) ◽  
pp. 3244-3251 ◽  
Author(s):  
Maarten H.K. Linskens ◽  
Junli Feng ◽  
William H. Andrews ◽  
Brett E. Enlow ◽  
Shahin M. Saati ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Display ◽  
Altered Gene Expression ◽  
Altered Gene

scholarly journals REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise

2017 ◽  
Vol 313 (6) ◽  
pp. E737-E747 ◽  
Author(s):  
Bradley S. Gordon ◽  
Jennifer L. Steiner ◽  
Michael L. Rossetti ◽  
Shuxi Qiao ◽  
Leif W. Ellisen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Aerobic Exercise ◽  
Acute Exercise ◽  
Gene Expression Signature ◽  
Model Systems ◽  
Expression Signature ◽  
Altered Gene Expression ◽  
Altered Gene ◽  
Exercise Induced

The metabolic stress placed on skeletal muscle by aerobic exercise promotes acute and long-term health benefits in part through changes in gene expression. However, the transducers that mediate altered gene expression signatures have not been completely elucidated. Regulated in development and DNA damage 1 (REDD1) is a stress-induced protein whose expression is transiently increased in skeletal muscle following acute aerobic exercise. However, the role of this induction remains unclear. Because REDD1 altered gene expression in other model systems, we sought to determine whether REDD1 induction following acute exercise altered the gene expression signature in muscle. To do this, wild-type and REDD1-null mice were randomized to remain sedentary or undergo a bout of acute treadmill exercise. Exercised mice recovered for 1, 3, or 6 h before euthanization. Acute exercise induced a transient increase in REDD1 protein expression within the plantaris only at 1 h postexercise, and the induction occurred in both cytosolic and nuclear fractions. At this time point, global changes in gene expression were surveyed using microarray. REDD1 induction was required for the exercise-induced change in expression of 24 genes. Validation by RT-PCR confirmed that the exercise-mediated changes in genes related to exercise capacity, muscle protein metabolism, neuromuscular junction remodeling, and Metformin action were negated in REDD1-null mice. Finally, the exercise-mediated induction of REDD1 was partially dependent upon glucocorticoid receptor activation. In all, these data show that REDD1 induction regulates the exercise-mediated change in a distinct set of genes within skeletal muscle.

scholarly journals Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Andreas Buch Møller ◽  
Ulla Kampmann ◽  
Jakob Hedegaard ◽  
Kasper Thorsen ◽  
Iver Nordentoft ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Insulin Resistant ◽  
Altered Gene Expression ◽  
Altered Gene

scholarly journals Exercise causes repositioning of the ‐1 nucleosome within the PGC1α promoter in association with altered gene expression in skeletal muscle (705.7)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Tara Henagan ◽  
Jeffrey Covington ◽  
Laura Stewart ◽  
Jose Galgani ◽  
Eric Ravussin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Altered Gene Expression ◽  
Altered Gene
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