Alterations of Remnant Liver Carnitine Palmitoyltransferase I Activity and Serum Carnitine Concentration after Partial Hepatectomy in Rats

1995 ◽  
Vol 59 (6) ◽  
pp. 754-758 ◽  
Author(s):  
Hong-Shiee Lai ◽  
Wei-Jao Chen
Keyword(s):  
Partial Hepatectomy ◽  
Carnitine Palmitoyltransferase ◽  
Remnant Liver ◽  
Carnitine Palmitoyltransferase I ◽  
Carnitine Concentration

scholarly journals Ketone-body metabolism after surgical stress or partial hepatectomy. Evidence for decreased ketogenesis and a site of control distal to carnitine palmitoyltransferase I

1987 ◽  
Vol 241 (2) ◽  
pp. 475-481 ◽  
Author(s):  
P S Schofield ◽  
T J French ◽  
M C Sugden
Keyword(s):  
Partial Hepatectomy ◽  
Ketone Body ◽  
Surgical Stress ◽  
Carnitine Palmitoyltransferase ◽  
Medium Chain ◽  
Medium Chain Length ◽  
Sustained Effects ◽  
Carnitine Palmitoyltransferase I ◽  
Cpt I ◽  
A Site

Rats were subjected to laparotomy, or laparotomy and partial hepatectomy, at 0-48 h before administration of water or medium-chain-length triacylglycerol, having been starved post-operatively. Functional hepatectomies were performed at intervals after the intragastric load. Blood ketone-body concentrations after medium-chain triacylglycerol administration and/or functional hepatectomy of these rats were compared with values obtained in starved control rats. Decreased ketonaemia in response to medium-chain triacylglycerol was observed for up to 48 h after partial hepatectomy and at 1 and 2 h after laparotomy, but not at 24 or 48 h after laparotomy. Rates of ketone-body clearance after functional hepatectomy were unaffected by prior laparotomy or partial hepatectomy. Ketonaemia after medium-chain-triacylglycerol administration was only partially blocked by inhibition of CPT I (carnitine palmitoyltransferase I). The results demonstrate sustained effects of partial hepatectomy and short-term effects of surgical stress to decrease ketonaemia via inhibition of ketogenesis at site(s) distal to CPT I.

scholarly journals Malonyl-CoA-independent Acute Control of Hepatic Carnitine Palmitoyltransferase I Activity

1998 ◽  
Vol 273 (34) ◽  
pp. 21497-21504 ◽  
Author(s):  
Guillermo Velasco ◽  
Math J. H. Geelen ◽  
Teresa Gómez del Pulgar ◽  
Manuel Guzmán
Keyword(s):  
Carnitine Palmitoyltransferase ◽  
Malonyl Coa ◽  
Carnitine Palmitoyltransferase I
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