Introduction: What do we Know Today About Form and Function of Cardiac Ion Channels?

2001 ◽  
Vol 33 (4) ◽  
pp. 597
Author(s):  
Penelope A. Boyden
Keyword(s):  
Ion Channels ◽  
Form And Function ◽  
Cardiac Ion Channels ◽  
And Function

scholarly journals The Form and Function of PIEZO2

2021 ◽  
Vol 90 (1) ◽  
pp. 507-534
Author(s):  
Marcin Szczot ◽  
Alec R. Nickolls ◽  
Ruby M. Lam ◽  
Alexander T. Chesler
Keyword(s):  
Shear Stress ◽  
Ion Channels ◽  
Molecular Level ◽  
Sensory Biology ◽  
Mechanical Stimuli ◽  
Functional Roles ◽  
Form And Function ◽  
The Past ◽  
And Function ◽  
Sense Of Touch

Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduced at the molecular level has proved to be one of the great mysteries of sensory biology. A major breakthrough occurred in 2010 with the discovery of a family of mechanically gated ion channels that were coined PIEZOs. The last 10 years of investigation have provided a wealth of information about the functional roles and mechanisms of these molecules. Here we focus on PIEZO2, one of the two PIEZO proteins found in humans and other mammals. We review how work at the molecular, cellular, and systems levels over the past decade has transformed our understanding of touch and led to unexpected insights into other types of mechanosensation beyond the skin.

Basic Cardiac Electrophysiology

2013 ◽  
pp. 171-190
Author(s):  
Hon-Chi Lee ◽  
Arshad Jahangir
Keyword(s):  
Ion Channels ◽  
Cardiac Arrhythmias ◽  
Action Potentials ◽  
Cardiac Electrophysiology ◽  
Structure And Function ◽  
Learning Objectives ◽  
Cardiac Ion Channels ◽  
Cardiac Action ◽  
And Function

The learning objectives of this chapter are to review some basic electrophysiologic concepts that are useful for the clinician. These include 1) the structure and function of cardiac ion channels; 2) the role of ion channels in the generation of cardiac action potentials; 3) the mechanisms of cardiac arrhythmias; and 4) inherited and acquired channelopathies.

Scanning tunneling microscopy (STM) of DNA and RNA

1989 ◽  
Vol 47 ◽  
pp. 34-35
Author(s):  
Patricia G. Arscott ◽  
Gil Lee ◽  
Victor A. Bloomfield ◽  
D. Fennell Evans
Keyword(s):  
Molecular Structures ◽  
Inorganic Materials ◽  
Resolving Power ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Form And Function ◽  
Dna And Rna ◽  
Calf Thymus ◽  
And Function ◽  
The Relationship

STM is one of the most promising techniques available for visualizing the fine details of biomolecular structure. It has been used to map the surface topography of inorganic materials in atomic dimensions, and thus has the resolving power not only to determine the conformation of small molecules but to distinguish site-specific features within a molecule. That level of detail is of critical importance in understanding the relationship between form and function in biological systems. The size, shape, and accessibility of molecular structures can be determined much more accurately by STM than by electron microscopy since no staining, shadowing or labeling with heavy metals is required, and there is no exposure to damaging radiation by electrons. Crystallography and most other physical techniques do not give information about individual molecules.We have obtained striking images of DNA and RNA, using calf thymus DNA and two synthetic polynucleotides, poly(dG-me5dC)·poly(dG-me5dC) and poly(rA)·poly(rU).

Re-examining the form and function of superstition

2011 ◽  
Author(s):  
Scott Fluke ◽  
Russell J. Webster ◽  
Donald A. Saucier
Keyword(s):  
Form And Function ◽  
And Function

A New Form and Function for Personality

2013 ◽  
Author(s):  
Joshua Wilt ◽  
William Revelle
Keyword(s):  
Form And Function ◽  
New Form ◽  
And Function

Ausnahmesegment

2018 ◽  
Vol 48 (191) ◽  
Author(s):  
Barbara Schönig
Keyword(s):  
Welfare State ◽  
Social Housing ◽  
Integrated Approach ◽  
New Paradigm ◽  
Development Models ◽  
Form And Function ◽  
Institutional Organization ◽  
National Welfare ◽  
And Function ◽  
The Welfare State

Going along with the end of the “golden age” of the welfare state, the fordist paradigm of social housing has been considerably transformed. From the 1980s onwards, a new paradigm of social housing has been shaped in Germany in terms of provision, institutional organization and design. This transformation can be interpreted as a result of the interplay between the transformation of national welfare state and housing policies, the implementation of entrepreneurial urban policies and a shift in architectural and urban development models. Using an integrated approach to understand form and function of social housing, the paper characterizes the new paradigm established and nevertheless interprets it within the continuity of the specific German welfare resp. housing regime, the “German social housing market economy”.

Sign in / Sign up

Export Citation Format

Share Document