Late Sodium Current is a Novel Target for Amiodarone: Studies in Failing Human Myocardium

2001 ◽  
Vol 33 (5) ◽  
pp. 923-932 ◽  
Author(s):  
Victor A Maltsev ◽  
Hani N Sabbah ◽  
Albertas I Undrovinas
Keyword(s):  
Sodium Current ◽  
Human Myocardium ◽  
Late Sodium Current ◽  
Novel Target

scholarly journals Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium

2018 ◽  
Vol 175 (13) ◽  
pp. 2635-2652 ◽  
Author(s):  
Cecilia Ferrantini ◽  
Josè Manuel Pioner ◽  
Luca Mazzoni ◽  
Francesca Gentile ◽  
Benedetta Tosi ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Sodium Current ◽  
In Vitro Study ◽  
Human Myocardium ◽  
Vitro Study ◽  
Late Sodium Current ◽  
Exercise Induced

scholarly journals Ranolazine Attenuates the Enhanced Reverse Na+-Ca2+ Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes

2014 ◽  
Vol 124 (3) ◽  
pp. 365-373 ◽  
Author(s):  
Xiao-Jing Wang ◽  
Lei-Lei Wang ◽  
Chen Fu ◽  
Pei-Hua Zhang ◽  
Ying Wu ◽  
...  
Keyword(s):  
Ventricular Myocytes ◽  
Sodium Current ◽  
Exchange Current ◽  
Late Sodium Current

Larger late sodium current density as well as greater sensitivities to ATX II and ranolazine in rabbit left atrial than left ventricular myocytes

2014 ◽  
Vol 306 (3) ◽  
pp. H455-H461 ◽  
Author(s):  
Antao Luo ◽  
Jihua Ma ◽  
Yejia Song ◽  
Chunping Qian ◽  
Ying Wu ◽  
...  
Keyword(s):  
Left Atrial ◽  
Ventricular Myocytes ◽  
Sodium Current ◽  
Left Ventricular ◽  
Atrial Myocytes ◽  
Open Probability ◽  
Late Sodium Current ◽  
Ventricular Cells ◽  
Open Time ◽  
Hill Slope

An increase of cardiac late sodium current ( INa.L) is arrhythmogenic in atrial and ventricular tissues, but the densities of INa.L and thus the potential relative contributions of this current to sodium ion (Na+) influx and arrhythmogenesis in atria and ventricles are unclear. In this study, whole-cell and cell-attached patch-clamp techniques were used to measure INa.L in rabbit left atrial and ventricular myocytes under identical conditions. The density of INa.L was 67% greater in left atrial (0.50 ± 0.09 pA/pF, n = 20) than in left ventricular cells (0.30 ± 0.07 pA/pF, n = 27, P < 0.01) when elicited by step pulses from −120 to −20 mV at a rate of 0.2 Hz. Similar results were obtained using step pulses from −90 to −20 mV. Anemone toxin II (ATX II) increased INa.L with an EC50 value of 14 ± 2 nM and a Hill slope of 1.4 ± 0.1 ( n = 9) in atrial myocytes and with an EC50 of 21 ± 5 nM and a Hill slope of 1.2 ± 0.1 ( n = 12) in ventricular myocytes. Na+ channel open probability (but not mean open time) was greater in atrial than in ventricular cells in the absence and presence of ATX II. The INa.L inhibitor ranolazine (3, 6, and 9 μM) reduced INa.L more in atrial than ventricular myocytes in the presence of 40 nM ATX II. In summary, rabbit left atrial myocytes have a greater density of INa.L and higher sensitivities to ATX II and ranolazine than rabbit left ventricular myocytes.

scholarly journals LATE SODIUM CURRENT INHIBITOR RANOLAZINE REDUCED SUSCEPTIBILITY TO RE-FIBRILLATIONS FOLLOWING LONG DURATION VF

2015 ◽  
Vol 31 (10) ◽  
pp. S190-S191
Author(s):  
M.A. Azam ◽  
N. Zamiri ◽  
S. Masse ◽  
M. Kusha ◽  
P.F. Lai ◽  
...  
Keyword(s):  
Sodium Current ◽  
Late Sodium Current ◽  
Long Duration

scholarly journals Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32659 ◽  
Author(s):  
Beatriz Trenor ◽  
Karen Cardona ◽  
Juan F. Gomez ◽  
Sridharan Rajamani ◽  
Jose M. Ferrero ◽  
...  
Keyword(s):  
Heart Failure ◽  
Human Heart ◽  
Sodium Current ◽  
Human Heart Failure ◽  
Late Sodium Current ◽  
Mechanistic Investigation

Selective Inhibition of the Late Sodium Current has No Adverse Effect on Electrophysiological or Contractile Function of the Normal Heart

2014 ◽  
Vol 63 (6) ◽  
pp. 512-519 ◽  
Author(s):  
Sarah Fernandes ◽  
Kirsten Hoyer ◽  
Gongxin Liu ◽  
Wei-Qun Wang ◽  
Arvinder K. Dhalla ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Contractile Function ◽  
Sodium Current ◽  
Selective Inhibition ◽  
Normal Heart ◽  
Late Sodium Current
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