Exogenous Nitric Oxide Can Trigger a Preconditioned State Through a Free Radical Mechanism, But Endogenous Nitric Oxide Is Not a Trigger of Classical Ischemic Preconditioning

2000 ◽  
Vol 32 (7) ◽  
pp. 1159-1167 ◽  
Author(s):  
Atsushi Nakano ◽  
Guang S Liu ◽  
Gerd Heusch ◽  
James M Downey ◽  
Michael V Cohen
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Ischemic Preconditioning ◽  
Radical Mechanism ◽  
Free Radical Mechanism ◽  
Endogenous Nitric Oxide ◽  
Exogenous Nitric Oxide

Derivation of rate constants for steps in the free-radical chain decomposition of paraffins

1962 ◽  
Vol 268 (1332) ◽  
pp. 36-45 ◽  
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Rate Constants ◽  
High Pressures ◽  
Radical Mechanism ◽  
Methyl Radicals ◽  
Saturated Hydrocarbons ◽  
Radical Chain ◽  
Free Radical Mechanism ◽  
Standard Values

The Rice-Herzfeld free-radical mechanism for the thermal decomposition of saturated hydrocarbons, including both the uninhibited reaction and that partially inhibited by nitric oxide, involves the rate constants of various individual steps. If standard values are assumed for the rate constants of H -abstraction from n -pentane by methyl radicals, alkyl radical recombination, and addition of methyl to nitric oxide, then those of all the steps for a series of paraffins can be found. The method depends on measurements of the rate constant in the region where the chain reaction is of the first order, the inhibitory action of nitric oxide as a function of paraffin pressure, and the acceleration of paraffin decomposition rate produced by high pressures of nitric oxide. Values are derived for propane, three pentanes ( neo -, iso - and normal pentane) and three octanes ( normal octane, 2:3:4-trimethyl pentane and 2:2:4-trimethyl pentane), and the variations of the several rate constants with structure are discussed.

Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation

2007 ◽  
Vol 42 (7) ◽  
pp. 1029-1038 ◽  
Author(s):  
Andrés Trostchansky ◽  
Valerie B. O'Donnell ◽  
Douglas C. Goodwin ◽  
Lisa M. Landino ◽  
Lawrence J. Marnett ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Free Radical ◽  
Radical Mechanism ◽  
Prostaglandin Endoperoxide ◽  
Free Radical Mechanism ◽  
Endoperoxide H Synthase

Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity

2000 ◽  
Vol 127 (1) ◽  
pp. 61-72 ◽  
Author(s):  
Corwin Hansch ◽  
Susan C. McKarns ◽  
Carr J. Smith ◽  
David J. Doolittle
Keyword(s):  
Free Radical ◽  
Radical Mechanism ◽  
Free Radical Mechanism

Dirhodium(II)-Catalyzed Diamination Reaction via a Free Radical Pathway

2021 ◽  
Author(s):  
Zhiying Fan ◽  
Zhifan Wang ◽  
Ruoyi Shi ◽  
Yuanhua Wang
Keyword(s):  
Free Radical ◽  
Bond Formation ◽  
Mechanistic Study ◽  
Radical Mechanism ◽  
Free Radical Mechanism

Unlike C-N bond formation with classical dirhodium(II)-nitrenoids as the key intermediate, dirhodium(II)-catalyzed 1,2-and 1,3-diamination reactions are realized by a free radical mechanism. A mechanistic study revealed that the reactions undergo...

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