Activation ofα1-Adrenergic Receptor during Ca2+Pre-conditioning Elicits Strong Protection against Ca2+Overload Injury via Protein Kinase C Signaling Pathway

1998 ◽  
Vol 30 (11) ◽  
pp. 2423-2435 ◽  
Author(s):  
Yigang Wang ◽  
Muhammad Ashraf
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathway ◽  
Adrenergic Receptor ◽  
Kinase C

scholarly journals RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes

2003 ◽  
Vol 278 (52) ◽  
pp. 52792-52801 ◽  
Author(s):  
Reshmi A. Rambaratsingh ◽  
James C. Stone ◽  
Peter M. Blumberg ◽  
Patricia S. Lorenzo
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathway ◽  
Phorbol Ester ◽  
Epidermal Keratinocytes ◽  
Kinase C ◽  
Mouse Epidermal Keratinocytes

scholarly journals Occurrence of protein kinase C-signaling pathway in rat ovary

1995 ◽  
Vol 67 ◽  
pp. 262
Author(s):  
F. Arakane ◽  
K. Fukunaga ◽  
K. Miyazaki ◽  
A. Ohshiee ◽  
K. Nishimura ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathway ◽  
Kinase C ◽  
Rat Ovary

Activation of bitter taste receptors in pulmonary nociceptors sensitizes TRPV1 channels through the PLC and PKC signaling pathway

2017 ◽  
Vol 312 (3) ◽  
pp. L326-L333 ◽  
Author(s):  
Qihai (David) Gu ◽  
Deanna S. Joe ◽  
Carolyn A. Gilbert
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase C ◽  
Signaling Pathway ◽  
Sensory Neurons ◽  
Bitter Taste ◽  
Right Atrial ◽  
Taste Receptors ◽  
Kinase C ◽  
Bitter Taste Receptors

Bitter taste receptors (T2Rs), a G protein-coupled receptor family capable of detecting numerous bitter-tasting compounds, have recently been shown to be expressed and play diverse roles in many extraoral tissues. Here we report the functional expression of T2Rs in rat pulmonary sensory neurons. In anesthetized spontaneously breathing rats, intratracheal instillation of T2R agonist chloroquine (10 mM, 0.1 ml) significantly augmented chemoreflexes evoked by right-atrial injection of capsaicin, a specific activator for transient receptor potential vanilloid receptor 1 (TRPV1), whereas intravenous infusion of chloroquine failed to significantly affect capsaicin-evoked reflexes. In patch-clamp recordings with isolated rat vagal pulmonary sensory neurons, pretreatment with chloroquine (1−1,000 µM, 90 s) concentration dependently potentiated capsaicin-induced TRPV1-mediated inward currents. Preincubating with diphenitol and denatonium (1 mM, 90 s), two other T2R activators, also enhanced capsaicin currents in these neurons but to a lesser extent. The sensitizing effect of chloroquine was effectively prevented by the phospholipase C inhibitor U73122 (1 µM) or by the protein kinase C inhibitor chelerythrine (10 µM). In summary, our study showed that activation of T2Rs augments capsaicin-evoked TRPV1 responses in rat pulmonary nociceptors through the phospholipase C and protein kinase C signaling pathway.

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