Increased Expression of Connective Tissue Growth Factor in the Infarct Zone of Experimentally Induced Myocardial Infarction in Rats

1998 ◽  
Vol 30 (11) ◽  
pp. 2411-2422 ◽  
Author(s):  
Hiromichi Ohnishi ◽  
Takefumi Oka ◽  
Shozo Kusachi ◽  
Tohru Nakanishi ◽  
Kenji Takeda ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Infarct Zone ◽  
Experimentally Induced

scholarly journals Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52120 ◽  
Author(s):  
Jørgen Gravning ◽  
Stein Ørn ◽  
Ole Jørgen Kaasbøll ◽  
Vladimir N. Martinov ◽  
Cord Manhenke ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Tissue Growth

scholarly journals Evaluation of circulating levels of CCN2/connective tissue growth factor in patients with ST-elevation myocardial infarction

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Vibeke Ritschel ◽  
Christian Shetelig ◽  
Ingebjørg Seljeflot ◽  
Shanmuganathan Limalanathan ◽  
Pavel Hoffmann ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
St Elevation Myocardial Infarction ◽  
St Elevation ◽  
Circulating Levels

scholarly journals Connective Tissue Growth Factor and Cardiac Fibrosis after Myocardial Infarction

2005 ◽  
Vol 53 (10) ◽  
pp. 1245-1256 ◽  
Author(s):  
Rachael G. Dean ◽  
Leanne C. Balding ◽  
Riccardo Candido ◽  
Wendy C. Burns ◽  
Zemin Cao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Ace Inhibition ◽  
Left Ventricular ◽  
Tissue Growth ◽  
Viable Myocardium ◽  
Border Zone ◽  
Collagen Protein

The temporal and spatial expression of transforming growth factor (TGF)-β1 and connective tissue growth factor (CTGF) was assessed in the left ventricle of a myocardial infarction (MI) model of injury with and without angiotensin-converting enzyme (ACE) inhibition. Coronary artery ligated rats were killed 1, 3, 7, 28, and 180 days after MI. TGF-β1, CTGF, and procollagen α1(I) mRNA were localized by in situ hybridization, and TGF-β1 and CTGF protein levels by immunohistochemistry. Collagen protein was measured using picrosirius red staining. In a separate group, rats were treated for 6 months with an ACE inhibitor. There were temporal and regional differences in the expression of TGF-β1, CTGF, and collagen after MI. Procollagen α1(I) mRNA expression increased in the border zone and scar peaking 1 week after MI, whereas collagen protein increased in all areas of the heart over the 180 days. Expression of TGF-β1 mRNA and protein showed major increases in the border zone and scar peaking 1 week after MI. The major increases in CTGF mRNA and protein occurred in the viable myocardium at 180 days after MI. Long-term ACE inhibition reduced left ventricular mass and decreased fibrosis in the viable myocardium, but had no effect on cardiac TGF-β1 or CTGF. TGF-β1 is involved in the initial, acute phase of inflammation and repair after MI, whereas CTGF is involved in the ongoing fibrosis of the heart. The antifibrotic benefits of captopril are not mediated through a reduction in CTGF.

scholarly journals Plasma Connective Tissue Growth Factor (CTGF/CCN2) Levels Predict Myocardial Infarction in the Veterans Affairs Diabetes Trial (VADT) Cohort

Diabetes Care ◽  
2018 ◽  
Vol 41 (4) ◽  
pp. 840-846 ◽  
Author(s):  
Kelly J. Hunt ◽  
Miran A. Jaffa ◽  
Sara M. Garrett ◽  
Deirdre K. Luttrell ◽  
Kenneth E. Lipson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Veterans Affairs ◽  
Tissue Growth

scholarly journals Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

2019 ◽  
Vol 4 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Laura E. Vainio ◽  
Zoltán Szabó ◽  
Ruizhu Lin ◽  
Johanna Ulvila ◽  
Raisa Yrjölä ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Cardiac Repair
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