The Particle Strength Exchange Method Applied to Axisymmetric Viscous Flows

2001 ◽  
Vol 168 (2) ◽  
pp. 519-526 ◽  
Author(s):  
E. Rivoalen ◽  
S. Huberson
Keyword(s):  
Viscous Flows ◽  
Exchange Method ◽  
Particle Strength ◽  
Particle Strength Exchange

CALCULATION OF PERIODIC VISCOUS FLOWS INITIATED BY NEAR-WALL BODY FORCE

2016 ◽  
Vol 47 (1) ◽  
pp. 51-63
Author(s):  
Sergey Viktorovich Manuilovich
Keyword(s):  
Body Force ◽  
Viscous Flows ◽  
Near Wall

Efficient approach for analysis of unsteady viscous flows in turbomachines

AIAA Journal ◽  
1998 ◽  
Vol 36 ◽  
pp. 2005-2012
Author(s):  
L. He ◽  
W. Ning
Keyword(s):  
Viscous Flows ◽  
Efficient Approach

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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