The Role of Polycarboxylic Acids in Calcium Phosphate Mineralization

2002 ◽  
Vol 250 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Achilles Tsortos ◽  
George H. Nancollas
Keyword(s):  
Calcium Phosphate ◽  
Polycarboxylic Acids ◽  
Phosphate Mineralization

scholarly journals Effect of precipitation inhibitors on calcium phosphate scale formation

1989 ◽  
Vol 67 (5) ◽  
pp. 850-856 ◽  
Author(s):  
Zahid Amjad
Keyword(s):  
Molecular Weight ◽  
Calcium Phosphate ◽  
Acrylic Acid ◽  
Polyacrylic Acid ◽  
Scale Formation ◽  
Comparative Data ◽  
Polycarboxylic Acids ◽  
Precipitation Inhibitors ◽  
Ph Stat

The highly reproducible pH-stat technique was used to study the influence of various types of inhibitors on the precipitation of calcium phosphate from solution. Three types of inhibitors were evaluated: (1) homo- and copolymers of acrylic acid, (2) polyphosphate and phosphonates, and (3) polycarboxylic acids. Experimental variables studied included pH, temperature, and inhibitor dosage all of which were found to greatly affect the precipitation of calcium phosphate. The role of polyacrylic acid molecular weight is addressed. Comparative data for the various types of inhibitors is discussed. Keywords: precipitation inhibitors, calcium phosphate scale formation.

scholarly journals The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation

2012 ◽  
Vol 109 (35) ◽  
pp. 14170-14175 ◽  
Author(s):  
S. Boonrungsiman ◽  
E. Gentleman ◽  
R. Carzaniga ◽  
N. D. Evans ◽  
D. W. McComb ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Intracellular Calcium ◽  
Apatite Formation ◽  
Bone Apatite

scholarly journals Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

2017 ◽  
Vol 8 ◽  
pp. 772-783 ◽  
Author(s):  
Mohamed Hamed Misbah ◽  
Mercedes Santos ◽  
Luis Quintanilla ◽  
Christina Günter ◽  
Matilde Alonso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Click Chemistry ◽  
Recombinant Dna ◽  
Fibrillar Structure ◽  
Cross Link ◽  
Recombinant Dna Technology ◽  
Peptide Epitope ◽  
Phosphate Mineralization ◽  
Potential Applications ◽  
Dna Technology

Understanding the mechanisms responsible for generating different phases and morphologies of calcium phosphate by elastin-like recombinamers is supreme for bioengineering of advanced multifunctional materials. The generation of such multifunctional hybrid materials depends on the properties of their counterparts and the way in which they are assembled. The success of this assembly depends on the different approaches used, such as recombinant DNA technology and click chemistry. In the present work, an elastin-like recombinamer bearing lysine amino acids distributed along the recombinamer chain has been cross-linked via Huisgen [2 + 3] cycloaddition. The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically bind to and nucleate calcium phosphate. The benefit of using click chemistry is that the hybrid elastin-like-statherin recombinamers cross-link without losing their fibrillar structure. Mineralization of the resulting hybrid elastin-like-statherin recombinamer hydrogels with calcium phosphate is described. Thus, two different hydroxyapatite morphologies (cauliflower- and plate-like) have been formed. Overall, this study shows that crosslinking elastin-like recombinamers leads to interesting matrix materials for the generation of calcium phosphate composites with potential applications as biomaterials.

scholarly journals Understanding the early stages of calcium phosphate mineralization through hyperpolarized NMR techniques.

2021 ◽  
Author(s):  
Tristan Georges ◽  
Ludovica Epasto ◽  
Albina Selimović ◽  
Dennis Kurzbach ◽  
Thierry Azaïs
Keyword(s):  
Calcium Phosphate ◽  
Early Stages ◽  
Phosphate Mineralization ◽  
Nmr Techniques
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