Serum Amyloid P Component and C-Reactive Protein Opsonize Apoptotic Cells for Phagocytosis through Fcγ Receptors

2002 ◽  
Vol 19 (3) ◽  
pp. 147-154 ◽  
Author(s):  
Carolyn Mold ◽  
Rebecca Baca ◽  
Terry W. Du Clos
Keyword(s):  
Serum Amyloid ◽  
Apoptotic Cells ◽  
C Reactive Protein ◽  
Fcγ Receptors ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

scholarly journals Vitamin D Correction Down-Regulates Serum Amyloid P Component Levels in Vitamin D Deficient Arab Adults: A Single-Arm Trial

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2880
Author(s):  
Osama Amer ◽  
Malak Khattak ◽  
Abdullah Alnaami ◽  
Naji Aljohani ◽  
Nasser Al-Daghri
Keyword(s):  
Vitamin D ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Post Intervention ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Study Participants ◽  
Amyloid P

Vitamin D (VD) has been observed to have anti-inflammatory properties. However, the effects of VD supplementation on the serum amyloid P component (SAP) has not been established. This study aimed to investigate the effect of VD supplementation on serum SAP levels in Arab adults. A total of 155 VD-deficient adult Saudis (56 males and 99 females) were recruited in this non-randomized, 6-month, single-arm trial. The intervention was as follows; cholecalciferol 50,000 international units (IU) every week for the first 2 months, followed by 50,000 twice a month for the next two months, and for the last two months, 1000 IU daily. Serum 25(OH)D, SAP, C-reactive protein (CRP), lipid profile, and glucose were assessed at baseline and post-intervention. At post-intervention, VD levels were significantly increased, while SAP levels significantly decreased in all study participants. Remarkably, this reduction in SAP was more significant in males than females after stratification. SAP was inversely correlated with VD overall (r = −0.17, p < 0.05), and only in males (r = −0.27, p < 0.05) after stratification according to sex after 6 months of VD supplementation. Such a relationship was not observed at baseline. VD supplementation can favorably modulate serum SAP concentrations in Arab adults, particularly in males.

Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component

Amyloid ◽  
2017 ◽  
Vol 24 (sup1) ◽  
pp. 28-29 ◽  
Author(s):  
Daisaku Ozawa ◽  
Ryo Nomura ◽  
P. Patrizia Mangione ◽  
Kazuhiro Hasegawa ◽  
Tadakazu Okoshi ◽  
...  
Keyword(s):  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P
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