Increased Serum Levels of Immunoglobulins, C-reactive Protein, Type 1 and Type 2 Cytokines in Patients with Mixed Connective Tissue Disease

1998 ◽  
Vol 11 (5) ◽  
pp. 503-508 ◽  
Author(s):  
Adla Bakri Hassan ◽  
Johan Rönnelid ◽  
Iva Gunnarsson ◽  
Göran Karlsson ◽  
Louise Berg ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Cytokines

Serum levels of anti-agalactosyl IgG antibodies in mixed connective tissue disease

2005 ◽  
Vol 152 (4) ◽  
pp. 806-807 ◽  
Author(s):  
Y. Mimura ◽  
H. Ihn ◽  
M. Jinnin ◽  
Y. Asano ◽  
K. Yamane ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Serum Levels ◽  
Igg Antibodies ◽  
Agalactosyl Igg

scholarly journals Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Joanna Salomon ◽  
Łukasz Matusiak ◽  
Danuta Nowicka-Suszko ◽  
Jacek C Szepietowski
Keyword(s):  
Atopic Dermatitis ◽  
Serum Level ◽  
Serum Levels ◽  
T Helper ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein ◽  
Helper Response ◽  
Severity Of The Disease

Chitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. The severity of the disease was assessed by the SCORAD and objective SCORAD indexes. The severity of pruritus was measured by the visual analogue scale. Blood samples were taken to examine serum level of YKL-40, total IgE level, C-reactive protein level, white blood cell count, and neutrophil count. YKL-40 serum levels were significantly higher in patients with atopic dermatitis compared to the controls. There was a positive correlation between YKL-40 concentration and SCORAD, objective SCORAD, and pruritus. This study has shown that YKL-40 serum level is increased in patients with atopic dermatitis and reflects the severity of symptoms.

Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents

2016 ◽  
Vol 0 (0) ◽  
Author(s):  
Ummugulsum Can ◽  
Muammer Buyukinan ◽  
Asuman Guzelant ◽  
Ayse Ugur ◽  
Adnan Karaibrahimoglu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Serum Levels ◽  
Inflammatory Biomarkers ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Age And Sex

AbstractBackground:Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), αMethods:This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70±1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, αResults:Serum Hp, fetuin-A (p<0.01) and PF-4, hs-CRP, SAP, AGP (p<0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum αConclusions:This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.

C-Reactive protein and insulin growth factor 1 serum levels during the menstrual cycle in adolescents with Type 1 diabetes

2015 ◽  
Vol 33 (1) ◽  
pp. 70-76 ◽  
Author(s):  
E. Codner ◽  
P. M. Merino ◽  
D. Martínez ◽  
P. Lopez ◽  
C. Godoy ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Growth Factor ◽  
Menstrual Cycle ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Insulin Growth Factor ◽  
Reactive Protein

Sensorineural Hearing Loss in Patients with Mixed Connective Tissue Disease: Immunological Markers and Cytokine Levels

2009 ◽  
Vol 36 (9) ◽  
pp. 1930-1936 ◽  
Author(s):  
AGOTA HAJAS ◽  
PETER SZODORAY ◽  
SANDOR BARATH ◽  
SANDOR SIPKA ◽  
SZILARD REZES ◽  
...  
Keyword(s):  
T Cells ◽  
Hearing Loss ◽  
Connective Tissue ◽  
Regulatory T Cells ◽  
Sensorineural Hearing Loss ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Disease Duration ◽  
Serum Levels ◽  
Sensorineural Hearing

Objective.To investigate the frequency of sensorineural hearing loss (SNHL) in patients with mixed connective tissue disease (MCTD).Methods.The study population consisted of 71 patients with MCTD (69 female; 2 male), with a mean age of 57.1 ± 7.9 years and a mean disease duration of 14.5 ± 8.0 years. All patients underwent audiological evaluation that included pure tone and speech audiometry. In addition, the systemic manifestations of the disease and drug therapy were recorded. All patients were tested for presence of autoantibodies. Fifty-one age-matched healthy subjects served as controls.Results.SNHL was found in 33 (46.4%) of the 71 patients with MCTD. There was no correlation between SNHL and age and disease duration. An association was found between Raynaud’s phenomenon (p < 0.03), secondary antiphospholipid syndrome (APS) (p < 0.05), and SNHL. MCTD patients with SNHL had higher serum levels of anti-U1RNP (p < 0.05), antiendothelial cell antibodies (p < 0.001), and IgG type anticardiolipin antibodies (p < 0.0001) than patients without SNHL. Serum levels of interferon-γ and tumor necrosis factor-α were increased in MCTD patients with SNHL compared to patients without SNHL. The absolute number of natural (CD4+CD25highFoxP+) regulatory T cells (Treg) was lower compared to patients without SNHL.Conclusion.In MCTD, SNHL is a specific organ manifestation and appears frequently. We have found that pathogenic autoantibodies, decreased levels of regulatory T cells, and overexpression of proinflammatory cytokines may play a role in the pathogenesis of immune mediated inner ear disorders in MCTD.

scholarly journals The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes

2019 ◽  
Vol 38 (2) ◽  
pp. 126-133 ◽  
Author(s):  
Dragana Popovic ◽  
Katarina Lalic ◽  
Aleksandra Jotic ◽  
Tanja Milicic ◽  
Jelena Bogdanovic ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Favorable Effect ◽  
Obese Patients ◽  
Risk Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hyperosmolar Hyperglycemic State ◽  
Group A

Summary Background We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP

FC130 Serum levels of type 1 and type 2 cytokines in melanoma patients

1997 ◽  
Vol 9 ◽  
pp. S145-S146
Author(s):  
S MORETTI ◽  
S MAZZOLI ◽  
F SEMPLICI ◽  
A CHIARUGI ◽  
N TOFANI ◽  
...  
Keyword(s):  
Serum Levels ◽  
Type 2 Cytokines ◽  
Melanoma Patients
Sign in / Sign up

Export Citation Format

Share Document