Effects of Estrogen Replacement Therapy on PET Cerebral Blood Flow and Neuropsychological Performance

1998 ◽  
Vol 34 (2) ◽  
pp. 171-182 ◽  
Author(s):  
Susan M. Resnick ◽  
Pauline M. Maki ◽  
Stephanie Golski ◽  
Michael A. Kraut ◽  
Alan B. Zonderman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Neuropsychological Performance ◽  
Estrogen Replacement

Effect of Estrogen Replacement Therapy on Endothelial Function of Peripheral Resistance Artery in Postmenopausal Women - Comparison of Normotensive Subjects and Hypertensive Patients -

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 713-713
Author(s):  
Yukihito Higashi ◽  
Mitsuhiro Sanada ◽  
Shota Sasaki ◽  
Keigo Nakagawa ◽  
Koso Ohama ◽  
...  
Keyword(s):  
Blood Flow ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Estrogen Replacement Therapy ◽  
Forearm Blood Flow ◽  
Reactive Hyperemia ◽  
Sublingual Nitroglycerin ◽  
Estrogen Replacement

P112 To determine whether endothelial dysfunction is demonstrable in the forearm circulation of hypertensive postmenopausal women (HPW) compared with normotensive postmenopausal women (NPW), and to evaluate the effects of long-term estrogen replacement therapy (ERT) on endothelial function in the HPW and NPW, we randomized both HPW and NPW into groups with ERT for 12 weeks (n=26 and 10) or with placebo (n=8 and 6), respectively. Forearm blood flow was measured using strain-gauge plethysmography during reactive hyperemia to test endothelium-dependent vasodilation, and after sublingual nitroglycerin administration to test endothelium-independent vasodilation. Basal forearm blood flow was similar in NPW and HPW. Forearm blood flow in HPW during reactive hyperemia was significantly less than that in NPW. Increases in forearm blood flow after nitroglycerin were similar in the two groups. ERT lowered LDL cholesterol and increased estradiol and HDL cholesterol; no change occurred in the placebo group. Changes in these parameters evoked by ERT were similar in HPW and NPW. Basal blood pressures, heart rate, forearm blood flow, or body weight was not changed by ERT. After 12 weeks of ERT, maximal forearm blood flow response during reactive hyperemia increased significantly from 18.4 ± 2.6 to 28.6 ± 3.4 mL/min/100 mL tissue (p<.05) in HPW and from 26.5 ± 1.9 to 30.9 ± 3.9 mL/min/100 mL tissue (p<.05) in NPW, but it was not changed by placebo. The improvement of reactive hyperemia after ERT was significantly greater in HPW than in NPW (56 ± 8 vs. 17 ± 3%, P<.05). Changes in forearm blood flow after sublingual nitroglycerin administration were similar before and after 12 weeks of ERT. These findings suggest that continued ERT improves endothelial dysfunction in postmenopausal women, and that HPW show endothelial dysfunction which can be improved by ERT via the mechanism other than beneficial effects on lipid metabolism.

Effect of estrogen replacement therapy on distribution of myocardial blood flow in female anesthetized rabbits

2001 ◽  
Vol 281 (3) ◽  
pp. H1407-H1412 ◽  
Author(s):  
J. R. Rouleau ◽  
A. Dagnault ◽  
D. Simard ◽  
B. Lavallée ◽  
A. Bélanger ◽  
...  
Keyword(s):  
Blood Flow ◽  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Oxygen Demand ◽  
Flow Distribution ◽  
Rate Pressure Product ◽  
Estrogen Replacement ◽  
Vascular Reserve ◽  
Coronary Pressure ◽  
17Β Estradiol

Estrogen replacement therapy reduces risk of cardiovascular events by altering coronary vasoregulation and distribution of blood flow. Vessel reactivity and blood flow distribution were assessed in anesthetized female rabbits in the following groups: 1) sham, 2) ovariectomy, 3) ovariectomy + 17β-estradiol, and 4) ovariectomy + dehydroepiandrosterone. After a 2-wk treatment, cardiac hemodynamics, vascular reserve, and blood flow were evaluated during the following infusions: 1) NaCl, or vehicle (0.5 ml/min), 2) acetylcholine (2 mg/kg), 3) isoproterenol (2 mg · kg−1 · min−1), and 4) chromonar (8 mg/kg). In hearts from ovariectomized rabbits, autoregulatory blood flow was preserved despite lower diastolic perfusion pressures (55 ± 8 vs. 64 ± 8 mmHg in sham) and rate-pressure product (14.4 ± 0.8 vs. 19.3 ± 0.8 beats/min · mmHg×10−3). Estrogen replacement therapy restored coronary pressure and reserve, and all drugs increased vascular conductance. In conclusion, in hearts from ovariectomized rabbits, vascular reserve declined because coronary pressure was lower; however, blood flow was preserved at a higher level than expected for oxygen demand. Estrogen replacement therapy restores myocardial oxygen supply-demand indices and returns coronary pressure-flow data to levels observed in animals with intact ovaries.

The Effects of Transdermal Estradiol and Oral Conjugated Estrogens on Haemostasis Variables

1994 ◽  
Vol 71 (04) ◽  
pp. 420-423 ◽  
Author(s):  
Ulla-Beth Kroon ◽  
G Silfverstolpe ◽  
L Tengborn
Keyword(s):  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Hormone Replacement ◽  
Plasminogen Activator Inhibitor ◽  
Estrogen Replacement ◽  
Transdermal Administration ◽  
Conjugated Estrogens ◽  
Transdermal Estradiol ◽  
Estrogen Administration ◽  
Activator Inhibitor

SummaryThe effects of oral and transdermal administration of estrogen replacement therapy (ERT) have been fairly well investigated regarding lipoprotein and carbohydrate metabolism, while the effects of different modes of estrogen administration on the haemostatic system have been less well studied.To delineate and compare the effects of perorally administered conjugated estrogens (CE) and transdermally administered estradiol (E2) in doses needed for hormone replacement therapy (HRT) on haemostasis parameters, 23 postmenopausal women were engaged in a study with an open cross-over design. The doses compared (0.625 mg CE and 50 μg E2/24h) are the lowest which, with few exceptions, eliminate climacteric symptoms. Both CE and E2 increased factor VII:C, factor VII:Ag, and the prothrombin fragment1+2. The increase in factor VII:Ag, however, was significantly higher after treatment with CE. These changes were all towards a state of hypercoagulability. Furthermore, CE decreased plasminogen activator inhibitor (PAI) and the thrombin-antithrombin complexes (TAT), as well as antithrombin (ATIII).

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