Activated Matrix Metalloproteinase-2—A Potential Marker of Prognosis for Epithelial Ovarian Cancer

2002 ◽  
Vol 84 (1) ◽  
pp. 126-134 ◽  
Author(s):  
Xiaohua Wu ◽  
Haili Li ◽  
Lin Kang ◽  
Li Li ◽  
Weiping Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Epithelial Ovarian Cancer ◽  
Matrix Metalloproteinase 2 ◽  
Potential Marker

Prognostic Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase 2 in Epithelial Ovarian Cancer

Tumor Biology ◽  
2007 ◽  
Vol 28 (5) ◽  
pp. 280-289 ◽  
Author(s):  
S. Sillanpää ◽  
M. Anttila ◽  
K. Suhonen ◽  
K. Hämäläinen ◽  
T. Turpeenniemi-Hujanen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Epithelial Ovarian Cancer ◽  
Prognostic Significance ◽  
Matrix Metalloproteinase 2 ◽  
Extracellular Matrix Metalloproteinase Inducer

Lysophosphatidic Acid Down-Regulates Stress Fibers and Up-Regulates Pro–Matrix Metalloproteinase-2 Activation in Ovarian Cancer Cells

2007 ◽  
Vol 5 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Thuy-Vy Do ◽  
Jay C. Symowicz ◽  
David M. Berman ◽  
Lance A. Liotta ◽  
Emanuel F. Petricoin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Lysophosphatidic Acid ◽  
Stress Fibers ◽  
Matrix Metalloproteinase 2 ◽  
Ovarian Cancer Cells

scholarly journals PAX8 is a potential marker for the diagnosis of primary epithelial ovarian cancer

2017 ◽  
Author(s):  
Hong‑Juan Chai ◽  
Qing Ren ◽  
Qin Fan ◽  
Liu Ye ◽  
Guang‑Ye Du ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Potential Marker ◽  
Primary Epithelial Ovarian Cancer

scholarly journals Urinary MMP-9/NGAL Ratio as a Potential Marker of FSGS in Nephrotic Children

2013 ◽  
Vol 34 (5) ◽  
pp. 357-362 ◽  
Author(s):  
Agata Korzeniecka-Kozerska ◽  
Anna Wasilewska ◽  
Edyta Tenderenda ◽  
Agnieszka Sulik ◽  
Kamil Cybulski
Keyword(s):  
Nephrotic Syndrome ◽  
Matrix Metalloproteinase ◽  
Minimal Change Nephrotic Syndrome ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Tissue Inhibitor ◽  
Potential Marker ◽  
Nephrotic Children ◽  
Metalloproteinase 9

BACKGROUND: The study was undertaken to develop a potential new markers for distinguishing minimal change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS) in children. We hypothesized that matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin (MMP-9/NGAL) is a better marker of focal sclerosis in the glomerulus then matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP-9/TIMP-1) and matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 MMP2/TIMP-2.METHODS: The present study used a sample of 36 children and adolescents subdivided into two groups: I – 20 children with MCNS, subjected to examination twice: A – in relapse of nephrotic syndrome, before treatment and B – after regression of proteinuria; II – 16 children with FSGS. MMPs and TIMPs and NGAL levels were measured in the urine using ELISA kit. MMP-9/TIMP-1, MMP-2/TIMP-2 and MMP-9/NGAL ratios were calculated.RESULTS: Median NGAL/cr. was significantly higher in MCNS and FSGS patients when compared to healthy controls. Both, NGAL and MMP-9 urinary levels were significantly elevated in FSGS subjects, as compared with control subjects. Contrary to FSGS children, in MCNS group, before treatment only NGAL/cr., but not MMP-9/cr. was increased. Urinary concentrations of NGAL and MMP-9 were highly associated with each other (NGAL/cr. vs. MMP-9/cr.,r= 0.485,p< 0.01). Median urine MMP-9/NGAL ratio in FSGS patients was significantly higher than in patients with MCNS. We also found that significant increase in MMP-9/NGAL was associated with FSGS [odds ratio (OR) – 9.0; confidence interval (CI) 1.97–41.07].CONCLUSION: MMP-9/NGAL ratio may serve as differentiation marker between MCNS and FSGS in nephrotic children.

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