Immunohistochemical Detection of Parathyroid Hormone-Related Protein in a Squamous Cell Carcinoma Arising from Mature Cystic Teratoma Causing Humoral Hypercalcemia of Malignancy

2000 ◽  
Vol 79 (3) ◽  
pp. 504-507 ◽  
Author(s):  
Kyousuke Takeuchi ◽  
Kazuo Murata ◽  
Kaoru Funaki ◽  
Souhei Kitazawa ◽  
Riko Kitazawa
1999 ◽  
Vol 123 (8) ◽  
pp. 725-730
Author(s):  
Manuel Crespo ◽  
Bernardo Sopeña ◽  
John J. Orloff ◽  
Jorge F. Cameselle Teijeiro ◽  
Pamela Dann ◽  
...  

Abstract Humoral hypercalcemia of malignancy is a cancer-related hypercalcemia caused by production of humoral factors by malignant cells in patients without bone metastases. Squamous cell carcinomas are the tumors most frequently associated with humoral hypercalcemia of malignancy, and parathyroid hormone–related protein is the main humoral factor implicated. In spite of the fact that normal keratinocytes produce parathyroid hormone–related protein, it is highly unusual for patients with squamous cell carcinomas of the skin to present with humoral hypercalcemia of malignancy. We present a well-documented case of cutaneous squamous cell carcinoma complicated by hypercalcemia in a patient with high levels of plasma parathyroid hormone–related protein and immunohistochemical evidence of high parathyroid hormone–related protein production by the tumoral cells.


2000 ◽  
Vol 123 (5) ◽  
pp. 558-562 ◽  
Author(s):  
Rani S. Sellers ◽  
David E. Schuller ◽  
Pramod K. Sharma ◽  
Sarah H. Tannehill-Gregg ◽  
Charles C. Capen ◽  
...  

2002 ◽  
Vol 37 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Takahito Saito ◽  
Kenichi Harada ◽  
Koichi Tsuneyama ◽  
Masaaki Hirano ◽  
Susumu Amaya ◽  
...  

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