Transcriptional Analysis of a Novel Cluster of LY-6 Family Members in the Human and Mouse Major Histocompatibility Complex: Five Genes with Many Splice Forms

Genomics ◽  
2002 ◽  
Vol 80 (1) ◽  
pp. 113-123 ◽  
Author(s):  
Meera Mallya ◽  
R.Duncan Campbell ◽  
Begoña Aguado
Keyword(s):  
Major Histocompatibility Complex ◽  
Family Members ◽  
Transcriptional Analysis ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex ◽  
Splice Forms ◽  
Human And Mouse

scholarly journals Presentation of numerous viral peptides to mouse major histocompatibility complex (MHC) class I-restricted T lymphocytes is mediated by the human MHC-encoded transporter or by a hybrid mouse-human transporter.

1993 ◽  
Vol 177 (6) ◽  
pp. 1785-1790 ◽  
Author(s):  
J W Yewdell ◽  
F Esquivel ◽  
D Arnold ◽  
T Spies ◽  
L C Eisenlohr ◽  
...  
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Antigen Processing ◽  
Class I ◽  
Gene Products ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex ◽  
Functional Complex ◽  
Human And Mouse

The major histocompatibility complex-encoded transporter associated with antigen processing (TAP) is required for the efficient presentation of cytosolic antigens to class I-restricted T cells. TAP is thought to be formed by the interaction of two gene products, termed TAP1 and TAP2. We find that TAPs consisting either of human subunits, or mouse TAP1 and human TAP2, facilitate the presentation of numerous defined viral peptides to mouse class I-restricted T cells. As human and mouse TAP2 and TAP1 differ in 23 and 28% of their residues, respectively, this indicates that TAP1 and TAP2 can form a functional complex with partners considerably different from those they coevolved with. Moreover, these findings indicate that widely disparate TAPs facilitate delivery of the same peptides to class I molecules. These findings suggest that TAP polymorphism does not greatly influence the types of peptides presented to the immune system.

The mouse major histocompatibility complex: some assembly required

1999 ◽  
Vol 167 (1) ◽  
pp. 211-221 ◽  
Author(s):  
Claire Amadou ◽  
Attila Kumánovics ◽  
Elsy P. Jones ◽  
Doris Lambracht-Washington ◽  
Masayasu Yoshino ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

scholarly journals Gene duplications in the TL region of the mouse major histocompatibility complex.

1985 ◽  
Vol 4 (6) ◽  
pp. 1431-1434 ◽  
Author(s):  
U. Hammerling ◽  
H. Ronne ◽  
E. Widmark ◽  
B. Servenius ◽  
M. Denaro ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Gene Duplications ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

scholarly journals T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

1991 ◽  
Vol 173 (3) ◽  
pp. 609-617 ◽  
Author(s):  
G Gammon ◽  
H M Geysen ◽  
R J Apple ◽  
E Pickett ◽  
M Palmer ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
T Cell Response ◽  
Single Amino Acid ◽  
Foreign Protein ◽  
Antigenic Determinants ◽  
Mouse Strains ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

T lymphocytes recognize discrete regions on an antigen. The specificity of the T cell responses in three mouse strains of differing major histocompatibility complex (MHC) haplotype to a protein antigen, lysozyme, was analyzed using a series of peptides that walk the antigen in single amino acid steps. These peptide series were synthesized using the pin synthesis system, which was modified to allow the peptides to be cleaved from the pins into a physiological buffer free of toxic compounds. This methodology overcomes many of the problems associated with the production of peptides for screening proteins for antigenic determinants. The T cell determinants for the three strains were markedly different. This result points out the limitations of algorithms predicting determinants without reference to the MHC, and the importance of the empirical methodology. This analysis of the T cell response to lysozyme constitutes the most complete study of reactivity to a foreign protein to date and illustrates many important features of antigen recognition by T cells, e.g., presence of major and minor determinant regions. The outer boundaries of each immunogenic region, the determinant envelope, are difficult to define from recently immunized lymph nodes because of the heterogeneity in T cell recognition. However, core sequences common to all the immunogenic peptides in a continuous sequence can be easily defined.

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