Genomic Organization of the Genes Gtf2ird1, Gtf2i, and Ncf1 at the Mouse Chromosome 5 Region Syntenic to the Human Chromosome 7q11.23 Williams Syndrome Critical Region

Genomics ◽  
2002 ◽  
Vol 79 (1) ◽  
pp. 137-143 ◽  
Author(s):  
Dashzeveg Bayarsaihan ◽  
Judit Dunai ◽  
John M. Greally ◽  
Kazuhiko Kawasaki ◽  
Kenta Sumiyama ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Williams Syndrome ◽  
Critical Region ◽  
Genomic Organization ◽  
Chromosome 5

scholarly journals Comparative Mapping of the Region of Human Chromosome 7 Deleted in Williams Syndrome

1999 ◽  
Vol 9 (5) ◽  
pp. 428-436 ◽  
Author(s):  
Udaya DeSilva ◽  
Hillary Massa ◽  
Barbara J. Trask ◽  
Eric D. Green
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Williams Syndrome ◽  
Nonhuman Primates ◽  
Physical Map ◽  
Artificial Chromosome ◽  
Genomic Region ◽  
Chromosome 7 ◽  
Fish Analysis ◽  
Chromosome 5

Williams syndrome (WS) is a complex developmental disorder resulting from the deletion of a large (∼1.5–2 Mb) segment of human chromosome 7q11.23. Physical mapping studies have revealed that this deleted region, which contains a number of known genes, is flanked by several large, nearly identical blocks of DNA. The presence of such highly related DNA segments in close physical proximity to one another has hampered efforts to elucidate the precise long-range organization of this segment of chromosome 7. To gain insight about the structure and evolutionary origins of this important and complex genomic region, we have constructed a fully contiguous bacterial artificial chromosome (BAC) and P1-derived artificial chromosome (PAC) contig map encompassing the corresponding region on mouse chromosome 5. In contrast to the difficulties encountered in constructing a clone-based physical map of the human WS region, the BAC/PAC-based map of the mouse WS region was straightforward to construct, with no evidence of large duplicated segments, such as those encountered in the human WS region. To confirm this difference, representative human and mouse BACs were used as probes for performing fluorescence in situ hybridization (FISH) to metaphase and interphase chromosomes. Human BACs derived from the nonunique portion of the WS region hybridized to multiple, closely spaced regions on human chromosome 7q11.23. In contrast, corresponding mouse BACs hybridized to a single site on mouse chromosome 5. Furthermore, FISH analysis revealed the presence of duplicated segments within the WS region of various nonhuman primates (chimpanzee, gorilla, orangutan, and gibbon). Hybridization was also noted at the genomic locations corresponding to human chromosome 7p22 and 7q22 in human, chimpanzee, and gorilla, but not in the other animal species examined. Together, these results indicate that the WS region is associated with large, duplicated blocks of DNA on human chromosome 7q11.23 as well as the corresponding genomic regions of other nonhuman primates. However, such duplications are not present in the mouse.

scholarly journals The gene coding for the p68 calcium-binding protein is localised to bands q32?q34 of human chromosome 5, and to mouse chromosome 11

1989 ◽  
Vol 82 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Adelina A. Davies ◽  
Stephen E. Moss ◽  
Mark R. Crompton ◽  
Tania A. Jones ◽  
Nigel K. Spurr ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Chromosome 11 ◽  
Chromosome 5 ◽  
Gene Coding ◽  
Mouse Chromosome 11 ◽  
Human Chromosome 5

IL9 maps to mouse chromosome 13 and human chromosome 5

1990 ◽  
Vol 31 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Beverly A. Mock ◽  
Marianne Krall ◽  
Christine A. Kozak ◽  
Muriel N. Nesbitt ◽  
O. Wesley McBride ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 5 ◽  
Chromosome 13 ◽  
Human Chromosome 5

Comparative mapping of the reeler gene on human Chromosome 7q22, rat Chromosome 4q11.2, and mouse Chromosome 5 A3-B1

1996 ◽  
Vol 7 (6) ◽  
pp. 468-469 ◽  
Author(s):  
Y. Matsuda ◽  
T. Takahara ◽  
M. Kusakabe ◽  
Y. Hayashizaki
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Comparative Mapping ◽  
Chromosome 5

scholarly journals The Epimorphin Gene Is Highly Conserved among Humans, Mice, and Rats and Maps to Human Chromosome 7, Mouse Chromosome 5, and Rat Chromosome 12

Genomics ◽  
1996 ◽  
Vol 37 (3) ◽  
pp. 386-389 ◽  
Author(s):  
Hongbin Zha ◽  
Elaine F. Remmers ◽  
Claude Szpirer ◽  
Josiane Szpirer ◽  
Heying Zhang ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 7 ◽  
Chromosome 12 ◽  
Chromosome 5 ◽  
Human Chromosome 7

scholarly journals Mitotic Checkpoint LocusMAD1L1Maps to Human Chromosome 7p22 and Mouse Chromosome 5

Genomics ◽  
1999 ◽  
Vol 55 (3) ◽  
pp. 363-364 ◽  
Author(s):  
Dong-Yan Jin ◽  
Christine A. Kozak ◽  
Faith Pangilinan ◽  
Forrest Spencer ◽  
Eric D. Green ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Mitotic Checkpoint ◽  
Chromosome 5

The β crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5

Genomics ◽  
1995 ◽  
Vol 25 (2) ◽  
pp. 574-576 ◽  
Author(s):  
Theo J.M. Hulsebos ◽  
Nancy A. Jenkins ◽  
Debra J. Gilbert ◽  
Neal G. Copeland
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 22 ◽  
Chromosome 5

The MurineCYLN2Gene: Genomic Organization, Chromosome Localization, and Comparison to the Human Gene That Is Located within the 7q11.23 Williams Syndrome Critical Region

Genomics ◽  
1998 ◽  
Vol 53 (3) ◽  
pp. 348-358 ◽  
Author(s):  
Casper C Hoogenraad ◽  
Bert H.J Eussen ◽  
An Langeveld ◽  
Rien van Haperen ◽  
Suzanne Winterberg ◽  
...  
Keyword(s):  
Williams Syndrome ◽  
Critical Region ◽  
Genomic Organization ◽  
Human Gene ◽  
Chromosome Localization
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