Succinyl-CoA:3-Ketoacid CoA Transferase (SCOT): Cloning of the Human SCOT Gene, Tertiary Structural Modeling of the Human SCOT Monomer, and Characterization of Three Pathogenic Mutations

Genomics ◽  
2000 ◽  
Vol 68 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Toshiyuki Fukao ◽  
Grant A. Mitchell ◽  
Xiang-Qian Song ◽  
Haruki Nakamura ◽  
Sacha Kassovska-Bratinova ◽  
...  
Keyword(s):  
Structural Modeling ◽  
Pathogenic Mutations ◽  
Coa Transferase

Characterization of propionate CoA-transferase from Ralstonia eutropha H16

2013 ◽  
Vol 98 (8) ◽  
pp. 3579-3589 ◽  
Author(s):  
Elena Volodina ◽  
Marc Schürmann ◽  
Nicole Lindenkamp ◽  
Alexander Steinbüchel
Keyword(s):  
Ralstonia Eutropha ◽  
Coa Transferase ◽  
Ralstonia Eutropha H16

scholarly journals Comparative In Vitro and In Silico Analyses of Variants in Splicing Regions of BRCA1 and BRCA2 Genes and Characterization of Novel Pathogenic Mutations

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57173 ◽  
Author(s):  
Mara Colombo ◽  
Giovanna De Vecchi ◽  
Laura Caleca ◽  
Claudia Foglia ◽  
Carla B. Ripamonti ◽  
...  
Keyword(s):  
In Silico ◽  
Brca1 And Brca2 ◽  
Pathogenic Mutations ◽  
Brca1 And Brca2 Genes ◽  
In Silico Analyses

Modeling the hierarchical structure of secondhand clothing buying behavior antecedents of millennials

2020 ◽  
Vol 15 (4) ◽  
pp. 1679-1708 ◽  
Author(s):  
Maria Esther Medalla ◽  
Kafferine Yamagishi ◽  
Ann Myril Tiu ◽  
Reciel Ann Tanaid ◽  
Dharyll Prince Mariscal Abellana ◽  
...  
Keyword(s):  
Hierarchical Structure ◽  
Current Literature ◽  
Design Methodology ◽  
Structural Modeling ◽  
Buying Behavior ◽  
Theoretical Frameworks ◽  
Content Type ◽  
The Hierarchical Structure ◽  
Holistic Analysis

Purpose Due to the growing dominance of the millennials in the secondhand clothing (SHC) market, it is crucial to understand the dynamics of their SHC buying behavior. Despite such significance, it has yet to be explored in the current literature. To address such a gap, this paper aims to explore the antecedents of the SHC buying behavior of millennials. Design/methodology/approach A purposive survey is conducted to establish relationships between the antecedents. As such, the interrelationships of the antecedents are modeled using the interpretative structural modeling (ISM) approach. Findings Results reveal that SHC antecedents exhibit several characteristics depending upon their characterization of being driving, dependence, linkage and autonomous variables. Originality/value This work pioneers the identification of SHC buying behavior antecedents specifically for the millennial market, as well as in the provision of a holistic analysis of the complex contextual relationships of these antecedents. The findings of this work provide insights that are crucial to the extant literature in developing theoretical frameworks and paradigms that help in understanding the dynamics of the SHC buying behavior. Moreover, such results are beneficial to marketing managers and practitioners in innovating their strategies to capture the millennial market better.

scholarly journals Structural Modeling and Biochemical Characterization of Recombinant KPN_02809, a Zinc-Dependent Metalloprotease from Klebsiella pneumoniae MGH 78578

2012 ◽  
Vol 13 (1) ◽  
pp. 901-917 ◽  
Author(s):  
Mun Teng Wong ◽  
Sy Bing Choi ◽  
Chee Sian Kuan ◽  
Siang Ling Chua ◽  
Chiat Han Chang ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Biochemical Characterization ◽  
Structural Modeling

Characterization of the large subunit of EcoHK31I methyltransferase by structural modeling and mutagenesis

2007 ◽  
Vol 388 (3) ◽  
Author(s):  
Amanda N.-S. Mak ◽  
Wai-To Fung ◽  
Kathy P.-S. Kong ◽  
Alice W.-S. Poon ◽  
Sai-Ming Ngai ◽  
...  
Keyword(s):  
Large Subunit ◽  
Structural Modeling

scholarly journals Degradation of Aromatics and Chloroaromatics by Pseudomonas sp. Strain B13: Cloning, Characterization, and Analysis of Sequences Encoding 3-Oxoadipate:Succinyl-Coenzyme A (CoA) Transferase and 3-Oxoadipyl-CoA Thiolase

2002 ◽  
Vol 184 (1) ◽  
pp. 216-223 ◽  
Author(s):  
Markus Göbel ◽  
Kerstin Kassel-Cati ◽  
Eberhard Schmidt ◽  
Walter Reineke
Keyword(s):  
Amino Acids ◽  
Coenzyme A ◽  
Tricarboxylic Acid Cycle ◽  
Tricarboxylic Acid ◽  
Open Reading Frames ◽  
Amino Acid Residues ◽  
Coa Transferase ◽  
Tricarboxylic Acid Cycle Intermediates ◽  
Reading Frames

ABSTRACT 3-Oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase carry out the ultimate steps in the conversion of benzoate and 3-chlorobenzoate to tricarboxylic acid cycle intermediates in bacteria utilizing the 3-oxoadipate pathway. This report describes the characterization of DNA fragments with the overall length of 5.9 kb from Pseudomonas sp. strain B13 that encode these enzymes. DNA sequence analysis revealed five open reading frames (ORFs) plus an incomplete one. ORF1, of unknown function, has a length of 414 bp. ORF2 (catI) encodes a polypeptide of 282 amino acids and starts at nucleotide 813. ORF3 (catJ) encodes a polypeptide of 260 amino acids and begins at nucleotide 1661. CatI and CatJ are the subunits of the 3-oxoadipate:succinyl-CoA transferase, whose activity was demonstrated when both genes were ligated into expression vector pET11a. ORF4, termed catF, codes for a protein of 401 amino acid residues with a predicted mass of 41,678 Da with 3-oxoadipyl-CoA thiolase activity. The last three ORFs seem to form an operon since they are oriented in the same direction and showed an overlapping of 1 bp between catI and catJ and of 4 bp between catJ and catF. Conserved functional groups important for the catalytic activity of CoA transferases and thiolases were identified in CatI, CatJ, and CatF. ORF5 (catD) encodes the 3-oxoadipate enol-lactone hydrolase. An incomplete ORF6 of 1,183 bp downstream of ORF5 and oriented in the opposite direction was found. The protein sequence deduced from ORF6 showed a putative AMP-binding domain signature.

Maroteaux–Lamy syndrome: Functional characterization of pathogenic mutations and polymorphisms in the arylsulfatase B gene

2008 ◽  
Vol 94 (3) ◽  
pp. 305-312 ◽  
Author(s):  
Elena Garrido ◽  
Bru Cormand ◽  
John J. Hopwood ◽  
Amparo Chabás ◽  
Daniel Grinberg ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Pathogenic Mutations ◽  
Arylsulfatase B
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