Analysis of HomologousXRCC1-Linked Zinc-Finger Gene Families in Human and Mouse: Evidence for Orthologous Genes

Genomics ◽  
1998 ◽  
Vol 49 (1) ◽  
pp. 112-121 ◽  
Author(s):  
Mark Shannon ◽  
Lisa Stubbs
Keyword(s):  
Zinc Finger ◽  
Gene Families ◽  
Orthologous Genes ◽  
Zinc Finger Gene ◽  
Human And Mouse

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates

Development ◽  
1999 ◽  
Vol 126 (6) ◽  
pp. 1259-1268 ◽  
Author(s):  
A. Meng ◽  
B. Moore ◽  
H. Tang ◽  
B. Yuan ◽  
S. Lin
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Dna Binding Domain ◽  
Related Gene ◽  
Presomitic Mesoderm ◽  
Zinc Finger Gene ◽  
Human And Mouse

The Drosophila doublesex (dsx) gene encodes a transcription factor that mediates sex determination. We describe the characterization of a novel zebrafish zinc-finger gene, terra, which contains a DNA binding domain similar to that of the Drosophila dsx gene. However, unlike dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites. Expression of terra in presomitic mesoderm is restricted to cells that lack expression of MyoD. In vivo, terra expression is reduced by hedgehog but enhanced by BMP signals. Overexpression of terra induces rapid apoptosis both in vitro and in vivo, suggesting that a tight regulation of terra expression is required during embryogenesis. Terra has both human and mouse homologs and is specifically expressed in mouse somites. Taken together, our findings suggest that terra is a highly conserved protein that plays specific roles in early somitogenesis of vertebrates.

scholarly journals miR-1279, miR-548j, miR-548m, and miR-548d-5p Binding Sites in CDSs of Paralogous and OrthologousPTPN12,MSH6, andZEB1Genes

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Anatoliy T. Ivashchenko ◽  
Assel S. Issabekova ◽  
Olga A. Berillo
Keyword(s):  
Gene Family ◽  
Mismatch Repair ◽  
Zinc Finger ◽  
Binding Sites ◽  
Animal Species ◽  
Tyrosine Phosphatase ◽  
Nucleotide Sequences ◽  
Orthologous Genes ◽  
Zinc Finger Gene ◽  
Dna Mismatch

OnlyPTPN12, MSH6, andZEB1have significant miR-1279 binding sites among paralogous genes of human tyrosine phosphatase family, DNA mismatch repair family, and zinc finger family, respectively. All miRNA binding sites are located within CDSs of studied mRNAs. Nucleotide sequences of hsa-miR-1279 binding sites with mRNAs of humanPTPN12, MSH6, andZEB1genes encode TKEQYE, EGSSDE, and GEKPYE oligopeptides, respectively. The conservation of miRNA binding sites encoding oligopeptides has been revealed. MRNAs of many paralogs of zinc finger gene family have from 1 to 12 binding sites coding the same GEKPYE hexapeptide. MRNAs ofPTPN12, MSH6, andZEB1orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides TKEQYE, EGSSDE, and GEKPYE. MiR-548j, miR-548m, and miR-548d-5p have homologous binding sites in the mRNA ofPTPN12orthologous genes which encode PRTRSC, TEATDI, and STASAT oligopeptides, respectively. All regions of miRNA are important for binding with the mRNA.

Tandem Zinc-Finger Gene Families in Mammals: Insights and Unanswered Questions

DNA Sequence ◽  
1998 ◽  
Vol 8 (5) ◽  
pp. 303-315 ◽  
Author(s):  
Mark Shannon ◽  
Joomyeong Kim ◽  
Linda Ashworth ◽  
Elbert Branscomb ◽  
Lisa Stubbs
Keyword(s):  
Zinc Finger ◽  
Gene Families ◽  
Zinc Finger Gene ◽  
Tandem Zinc Finger

Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3

1999 ◽  
Vol 1444 (2) ◽  
pp. 218-230 ◽  
Author(s):  
Xiaoguang Chen ◽  
Melanie Hamon ◽  
Zuoming Deng ◽  
Michael Centola ◽  
Raman Sood ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Gene ◽  
Identification And Characterization

Comprehensive analysis of CCCH-type zinc finger gene family in citrus (Clementine mandarin) by genome-wide characterization

2014 ◽  
Vol 289 (5) ◽  
pp. 855-872 ◽  
Author(s):  
Shengrui Liu ◽  
Muhammad Rehman Gul Khan ◽  
Yongping Li ◽  
Jinzhi Zhang ◽  
Chungen Hu
Keyword(s):  
Gene Family ◽  
Zinc Finger ◽  
Comprehensive Analysis ◽  
Zinc Finger Gene ◽  
Genome Wide

scholarly journals Expression of the zinc finger gene EVI-1 in ovarian and other cancers

1996 ◽  
Vol 74 (10) ◽  
pp. 1518-1525 ◽  
Author(s):  
DJ Brooks ◽  
S Woodward ◽  
FH Thompson ◽  
B Dos Santos ◽  
M Russell ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Gene

scholarly journals Assessment of orthologous splicing isoforms in human and mouse orthologous genes

BMC Genomics ◽  
2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Federico Zambelli ◽  
Giulio Pavesi ◽  
Carmela Gissi ◽  
David S Horner ◽  
Graziano Pesole
Keyword(s):  
Orthologous Genes ◽  
Splicing Isoforms ◽  
Human And Mouse
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