Genomic Organization, Complete Sequence, and Chromosomal Location of the Gene for Human Eotaxin (SCYA11), an Eosinophil-Specific CC Chemokine

Genomics ◽  
1997 ◽  
Vol 41 (3) ◽  
pp. 471-476 ◽  
Author(s):  
Eduardo A. Garcia-Zepeda ◽  
Marc E. Rothenberg ◽  
Stanislawa Weremowicz ◽  
Mindy N. Sarafi ◽  
Cynthia C. Morton ◽  
...  
Keyword(s):  
Genomic Organization ◽  
Chromosomal Location ◽  
Complete Sequence ◽  
Cc Chemokine

scholarly journals Sequence Analysis of Inducible Prophage phIS3501 Integrated into the Haemolysin II Gene of Bacillus thuringiensis var israelensis ATCC35646

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Bouziane Moumen ◽  
Christophe Nguen-The ◽  
Alexei Sorokin
Keyword(s):  
Staphylococcus Aureus ◽  
Sequence Analysis ◽  
Bacillus Thuringiensis ◽  
Bacillus Cereus ◽  
Genomic Organization ◽  
Food Poisoning ◽  
Complete Sequence ◽  
Bacterial Host ◽  
Regulation Of Synthesis ◽  
Selection For

Diarrheic food poisoning by bacteria of the Bacillus cereus group is mostly due to several toxins encoded in the genomes. One of them, cytotoxin K, was recently identified as responsible for severe necrotic syndromes. Cytotoxin K is similar to a class of proteins encoded by genes usually annotated as haemolysin II (hlyII) in the majority of genomes of the B. cereus group. The partially sequenced genome of Bacillus thuringiensis var israelensis ATCC35646 contains several potentially induced prophages, one of them integrated into the hlyII gene. We determined the complete sequence and established the genomic organization of this prophage-designated phIS3501. During induction of excision of this prophage with mitomycin C, intact hlyII gene is formed, thus providing to cells a genetic ability to synthesize the active toxin. Therefore, this prophage, upon its excision, can be implicated in the regulation of synthesis of the active toxin and thus in the virulence of bacterial host. A generality of selection for such systems in bacterial pathogens is indicated by the similarity of this genetic arrangement to that of Staphylococcus aureus  β-haemolysin.

The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc

2004 ◽  
Vol 19 (3) ◽  
pp. 303-318 ◽  
Author(s):  
D.J. Culp ◽  
L.R. Latchney ◽  
M.A. Fallon ◽  
P.A. Denny ◽  
P.C. Denny ◽  
...  
Keyword(s):  
Tandem Repeats ◽  
Genomic Organization ◽  
Splice Variants ◽  
Transcriptional Start Site ◽  
Mucous Cell ◽  
Complete Sequence ◽  
Full Length ◽  
Start Codon ◽  
Rich Domain ◽  
Translational Start

We previously demonstrated expression of full-length transcripts for sublingual mucin apoprotein, Muc19, of ∼24 kb (Fallon MA, Latchney LR, Hand AR, Johar A, Denny PA, Georgel PT, Denny PC, and Culp DJ. Physiol Genomics 14: 95–106, 2003). We now describe the complete sequence and genomic organization of the apomucin encoded by 43 exons. Southern analyses indicate a central exon of ∼18 kb containing 36 tandem repeats, each encoding 163 residues rich in serine and threonine. Full-length transcripts are an estimated 22,795 bp in length that span 106 kb of genomic DNA. The transcriptional start site is 24 bp downstream of a TATA box and 42 bp upstream of the conceptual translational start codon. The putative apoprotein has an estimated mass of 693.4 kDa and contains 7,524 amino acids (80% serine, threonine, glycine, alanine, and proline). We present a model for rat Muc19 transcripts and compare the conceptually translated Muc19 proteins for mouse, rat, pig, and the 3′ end of human Muc19. Conserved among these apoproteins are a signal peptide, a large tandem repeat region, von Willebrand factor type C and D domains, a trypsin inhibitor-like Cys-rich domain, and a COOH-terminal cystine knot-like domain. Southern blot analyses indicate transcripts for Muc19 and Smgc (submandibular gland protein C) are splice variants of a larger gene, Muc19/ Smgc. Comparative Northern analyses between the major salivary glands demonstrate highly selective Muc19 expression in neonatal and adult sublingual glands, whereas Smgc is expressed in neonatal submandibular and sublingual glands. Regulation of Muc19/ Smgc gene expression is discussed with respect to alternative splicing and mucous cell cytodifferentiation.

Genomic Organization and Chromosomal Location of the Mouse Vasoactive Intestinal Polypeptide 1 (VPAC1) Receptor

Genomics ◽  
1999 ◽  
Vol 58 (1) ◽  
pp. 90-93 ◽  
Author(s):  
Hitoshi Hashimoto ◽  
Akiko Nishino ◽  
Norihito Shintani ◽  
Nami Hagihara ◽  
Neal G. Copeland ◽  
...  
Keyword(s):  
Vasoactive Intestinal Polypeptide ◽  
Genomic Organization ◽  
Chromosomal Location ◽  
Vpac1 Receptor ◽  
Intestinal Polypeptide

Genomic Organization and Chromosomal Location of MurineCdc42

Genomics ◽  
1996 ◽  
Vol 38 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Peter W. Marks ◽  
David J. Kwiatkowski
Keyword(s):  
Genomic Organization ◽  
Chromosomal Location

scholarly journals Genomic organization and complete sequence of the human gene encoding the β-subunit of the cGMP phosphodiesterase and its localisation to 4p16.3

1991 ◽  
Vol 19 (22) ◽  
pp. 6263-6268 ◽  
Author(s):  
Bernhard Weber ◽  
Olaf Riess ◽  
Gordon Hutchinson ◽  
Colin Collins ◽  
Biaoyang Lin ◽  
...  
Keyword(s):  
Genomic Organization ◽  
Human Gene ◽  
Complete Sequence ◽  
Β Subunit ◽  
Gene Encoding ◽  
Cgmp Phosphodiesterase

Genomic Organization and Biological Characterization of the Novel Human CC Chemokine DC-CK-1/PARC/MIP-4/SCYA18

Genomics ◽  
1999 ◽  
Vol 56 (3) ◽  
pp. 296-302 ◽  
Author(s):  
Ping Guan ◽  
Arthur H.M. Burghes ◽  
Anne Cunningham ◽  
Paul Lira ◽  
William H. Brissette ◽  
...  
Keyword(s):  
Genomic Organization ◽  
The Novel ◽  
Biological Characterization ◽  
Cc Chemokine

Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7

1992 ◽  
Vol 36 (3) ◽  
pp. 175-181 ◽  
Author(s):  
Annamalai Selvakumar ◽  
Bhaskara K. Mohanraj ◽  
Roger L. Eddy ◽  
Thomas B. Shows ◽  
Perrin C. White ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Genomic Organization ◽  
Chromosomal Location ◽  
Human Gene ◽  
Lymphocyte Activation ◽  
Gene Encoding ◽  
B Lymphocyte Activation ◽  
Activation Antigen

Genomic Organization and Chromosomal Location of the Mouse Type I BMP-2/4 Receptor

1995 ◽  
Vol 206 (1) ◽  
pp. 310-317 ◽  
Author(s):  
Y. Mishina ◽  
A. Suzuki ◽  
D.J. Gilbert ◽  
N.G. Copeland ◽  
N.A. Jenkins ◽  
...  
Keyword(s):  
Genomic Organization ◽  
Chromosomal Location ◽  
Type I
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