Characterization of a Sea Bream (Sparus aurata) Thyroid Hormone Receptor-β Clone Expressed during Embryonic and Larval Development

2001 ◽  
Vol 123 (1) ◽  
pp. 80-89 ◽  
Author(s):  
M.A. Nowell ◽  
D.M. Power ◽  
A.V.M. Canario ◽  
L. Llewellyn ◽  
G.E. Sweeney
Keyword(s):  
Thyroid Hormone ◽  
Larval Development ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Sparus Aurata ◽  
Sea Bream ◽  
Thyroid Hormone Receptor Β ◽  
Embryonic And Larval Development

Expression of Thyroid Hormone Receptor during Early Development of the Sea Bream (Sparus aurata)a

1998 ◽  
Vol 839 (1 TRENDS IN COM) ◽  
pp. 610-611 ◽  
Author(s):  
LYNDA LLEWELLYN ◽  
VIMI P. RAMSURN ◽  
GLEN E. SWEENEY ◽  
TREVOR WIGHAM ◽  
DEBORAH M. POWER
Keyword(s):  
Thyroid Hormone ◽  
Early Development ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Sparus Aurata ◽  
Sea Bream

scholarly journals Thyroid hormone receptor β mutations in the ‘hot-spot region’ are rare events in thyroid carcinomas

2007 ◽  
Vol 192 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Ana Sofia Rocha ◽  
Ricardo Marques ◽  
Inês Bento ◽  
Ricardo Soares ◽  
João Magalhães ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Hormone ◽  
Transgenic Mice ◽  
Cell Lines ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hot Spot ◽  
Direct Sequencing ◽  
Human Thyroid ◽  
Thyroid Hormone Receptor Β

Thyroid cancer constitutes the most frequent endocrine neoplasia. Targeted expression of rearranged during transfection (RET)/papillary thyroid carcinoma (PTC) and V600E V-raf murine sarcoma viral oncogene homolog B1 (BRAF) to the thyroid glands of transgenic mice results in tumours similar to those of human PTC, providing evidence for the involvement of these oncogenes in PTC. Kato et al. developed a mouse model that mimics the full spectrum of the human follicular form of thyroid cancer (FTC). FTC rapidly develops in these mice through introduction of the thyroid hormone receptor β (THRB)PV mutant on the background of the inactivated THRB wt locus. Our aim was to verify if, in the context of human follicular thyroid carcinogenesis, THRB acted as a tumour suppressor gene. We screened for mutations of the THRB gene in the hot-spot region, spanning exons 7–10, in 51 thyroid tumours and six thyroid cancer cell lines by PCR and direct sequencing. We did not find mutations in any of the tumours or cell lines analysed. Our findings suggest that, in contrast to the findings on the THRB-mutant transgenic mice, THRB gene mutations are not a relevant mechanism for human thyroid carcinogenesis.

A Novel Point Mutation of Thyroid Hormone Receptor β Gene in a Family with Resistance to Thyroid Hormone

Thyroid ◽  
1997 ◽  
Vol 7 (5) ◽  
pp. 771-773 ◽  
Author(s):  
TOMOHISA NAGASHIMA ◽  
HIDEKI YAGI ◽  
KANJI NAGASHIMA ◽  
AKIHIRO SAKURAI ◽  
KAZUMICHI ONIGATA ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Point Mutation ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Receptor Β
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