Handbook of Physiology, Section 7, The Endocrine System, Volume III, Endocrine Regulation of Water and Electrolyte Balance. Edited by John C. S. Fray

2000 ◽  
Vol 119 (2) ◽  
pp. 239
2021 ◽  
Vol 14 (3) ◽  
pp. 4-12
Author(s):  
Agunda V. Dzagaxova ◽  
Nino N. Katamadze ◽  
Ekaterina A. Pigarova

Hyponatremia is the most common disorder of water and electrolyte balance encountered in clinical practice. Conditions associated with hyponatremia require hospitalization in 15–20% of cases. Hyponatremia is a predictor of poor outcome in a wide range of diseases and therefore requires an interdisciplinary approach. This problem leads to an increase in complications and the length of hospital stay and mortality. The review focuses on the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), which accounts for approximately one third of all cases of hyponatremia and is more common in endocrinology than other fluid and electrolyte disorders along with central diabetes insipidus. The article presents modern approaches to the treatment of SIADH based on international clinical guidelines.


Author(s):  
Margit G. Proescholdt ◽  
Marc Walter

Alcohol has widespread effects on multiple organs, including the endocrine organs, potentially impairing endocrine function and affecting the entire endocrine milieu. Endocrine impairment may be observed with acute alcohol ingestion, excessive chronic alcohol consumption, and during alcohol withdrawal. Whereas many effects of alcohol on the endocrine organs are reversible following cessation of alcohol consumption, some changes may extend into abstinence. Importantly, endocrine dysfunction observed in alcoholism, is no longer considered to simply result from hepatic failure or chronic malnutrition, but, at least partially, from direct, toxic actions of alcohol on the endocrine organs themselves. In addition, there is increasing evidence that the endocrine system itself may play a crucial role in the pathogenesis of addictive behaviour. Ethanol and its metabolite acetaldehyde directly affect cell membranes and influences intracellular metabolism. Indirect effects include stress, nausea, and vomiting during acute intoxication and withdrawal. Whereas the list of alcohol-induced endocrine dysfunction is long, scientific and epidemiological evidence is frequently controversial. Controversies may result from the highly heterogenic group of alcohol-dependent individuals regarding dose and duration of alcohol consumption, periods of abstinence, age, gender, nutritional status, cigarette smoking, use of other drugs, presence of other diseases, particularly liver disease, and the complexity of endocrine regulation in general.


1991 ◽  
Vol 34 (2) ◽  
pp. 115-118 ◽  
Author(s):  
J. Santavirta ◽  
A. Harmoinen ◽  
A. L. Karvonen ◽  
M. Matikainen

1951 ◽  
Vol 27 (311) ◽  
pp. 434-441
Author(s):  
J. Conway ◽  
J. Lee ◽  
W. O. Sykes

1939 ◽  
Vol 110 (6) ◽  
pp. 1050 ◽  
Author(s):  
J. RUSSELL ELKINTON ◽  
MONROE T. GILMOUR ◽  
WILLIAM A. WOLFF

2012 ◽  
pp. 493-505 ◽  
Author(s):  
Robert W. Kenefick ◽  
Samuel N. Cheuvront ◽  
Scott J. Montain ◽  
Robert Carter ◽  
Michael N. Sawka

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