EPA's Neurotoxicity Risk Assessment Guidelines, ,

1997 ◽  
Vol 40 (2) ◽  
pp. 175-184 ◽  
Author(s):  
W Boyes
Keyword(s):  
Risk Assessment ◽  
Assessment Guidelines

Exploring the contributions of components of caries risk assessment guidelines

2008 ◽  
Vol 36 (4) ◽  
pp. 357-362 ◽  
Author(s):  
James D. Bader ◽  
Nancy A. Perrin ◽  
Gerardo Maupom ◽  
William A. Rush ◽  
Brad D. Rindal
Keyword(s):  
Risk Assessment ◽  
Caries Risk ◽  
Caries Risk Assessment ◽  
Assessment Guidelines

Abstract 3631: Elevated In-hospital Glucose Level, and not Known History of Diabetes Mellitus, Predicts 30-day Mortality Following Acute ST-elevation Myocardial Infarction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Abhinav Goyal ◽  
Rafael Diaz ◽  
Hertzel C Gerstein ◽  
Rizwan Afzal ◽  
Shamir R Mehta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Assessment ◽  
Glucose Level ◽  
Early Death ◽  
Glucose Levels ◽  
Assessment Guidelines ◽  
History Of ◽  
Acute Mi ◽  
St Elevation ◽  
The Impact

Introduction: According to clinical risk assessment guidelines, a history of diabetes mellitus (DM) portends poor outcomes following acute MI. Elevated in-hospital glucose levels also predict early mortality in acute MI patients, but the degree to which glucose levels and diabetic history independently predict post-MI mortality is unclear. Methods and Hypothesis: We analyzed data from the combined cohort of the CREATE-ECLA and OASIS-6 randomized trials that evaluated the impact of glucose-insulin-potassium (GIK) infusion versus no infusion on 30-day mortality in 22,943 patients hospitalized with acute ST-elevation MI. We calculated the average in-hospital glucose level for each patient (mean of the admission, 6-hour, and 24-hour glucose levels). Logistic regression was performed to determine whether average glucose level and history of DM remained significant mortality predictors after adjusting for age, sex, and GIK allocation. Results: Glucose data were recorded in 22,860 (99.6%) patients; 10,050 (44%) had an average in-hospital glucose level ≥ 8 mmol/L (144 mg/dL), of whom 65% did not have known prior DM. Among patients with glucose >8 mmol/L, 30-day mortality rates were similar in patients with and without known DM (Figure ). In-hospital glucose, but not history of DM, was a significant multivariable predictor of mortality (Table). Conclusions: By considering only history of DM and not in-hospital glucose levels, risk assessment guidelines for acute MI overlook a large proportion of patients at high risk for early death. Therefore, clinicians should emphasize elevated glucose levels in addition to history of DM as a risk marker in patients with acute MI.

Assuming the Conclusions: Risk Assessment in the Development of Cancer Policy

1985 ◽  
Vol 4 (1) ◽  
pp. 31-44 ◽  
Author(s):  
Mark E. Rushefsky
Keyword(s):  
Risk Assessment ◽  
Risk Management ◽  
Policy Development ◽  
Cancer Risk Assessment ◽  
Acceptable Risk ◽  
Policy Documents ◽  
The Face ◽  
Assessment Guidelines ◽  
Objective Determination

This article examines the development of generic cancer risk assessment guidelines, or cancer policy, from 1976-1984. Risk assessment is considered the objective determination of the degree of risk from a substance. Risk management is the subjective determination of acceptable risk. However, uncertainties in the scientific foundations of cancer policy necessitate risk assessment inference choices, for example, over appropriate dose-response extrapolation models. Those choices are only partially scientific; they are also partially political. There is, as a result, an inevitable mixture of facts and values in cancer policy. The article explores ten inference controversies and evaluates how nine cancer policy documents resolved those controversies. It then traces the course of cancer policy development, showing how the Carter and Reagan administrations produced policies with difference emphases and considers several major challenges to cancer policy. The article then provides several justifications for cancer policy in the face of those challenges. It suggests, in the conclusion, that the controversies are unlikely to be resolved by science alone and politics will continue to influence the content of cancer policies.

Series: EU Risk Assessment Guidelines

1998 ◽  
Vol 5 (4) ◽  
pp. 217-222 ◽  
Author(s):  
Stefan Schwartz ◽  
Volker Berding ◽  
Stefan Trapp ◽  
Michael Matthies
Keyword(s):  
Risk Assessment ◽  
Assessment Guidelines

New Risk Assessment Initiatives in Epa

1985 ◽  
Vol 1 (4) ◽  
pp. 7-22 ◽  
Author(s):  
Elizabeth L. Anderson ◽  
Alan M. Ehrlich
Keyword(s):  
Risk Assessment ◽  
Risk Assessments ◽  
Technical Competence ◽  
Assessment Guidelines

This paper describes EPA's recent efforts to ensure consistency and technical competence of the agency's risk assessments. These include five risk assessment guidelines proposed in November 1984 and January 1985 and establishment of a Risk Assessment Forum. The technical provisions of the five guidelines have been outlined.

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