Nongenotoxic Effects of Polycyclic Aromatic Hydrocarbons and Their Ozonation By-Products on the Intercellular Communication of Rat Liver Epithelial Cells

1994 ◽  
Vol 23 (3) ◽  
pp. 470-475 ◽  
Author(s):  
B Upham
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Epithelial Cells ◽  
Rat Liver ◽  
Aromatic Hydrocarbons ◽  
Intercellular Communication ◽  
Liver Epithelial Cells ◽  
Polycyclic Aromatic ◽  
Rat Liver Epithelial Cells ◽  
By Products

Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells

2005 ◽  
Vol 386 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Kotb Abdelmohsen ◽  
Claudia von Montfort ◽  
Dominik Stuhlmann ◽  
P. Arne Gerber ◽  
Ulrich K.M. Decking ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Rat Liver ◽  
Intercellular Communication ◽  
Connexin 43 ◽  
Egf Receptor ◽  
Gap Junctional Intercellular Communication ◽  
Erk Activation ◽  
Liver Epithelial Cells ◽  
Rat Liver Epithelial Cells ◽  
Gap Junctional

Abstract Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC). Gap junctions are clusters of inter-cellular channels consisting of connexins, the major connexin in the cells used being connexin-43 (Cx43). Doxorubicin-induced loss of GJC was mediated by activation of extracellular signal-regulated kinase (ERK)-1 and ERK-2, as demonstrated using inhibitors of ERK activation. Furthermore, activation of the epidermal growth factor (EGF) receptor by doxorubicin was responsible for ERK activation and the subsequent attenuation of GJC. Inhibition of GJC, however, was not by direct phosphorylation of Cx43 by ERK-1/2, whereas menadione, a 1,4-naphthoquinone derivative that was previously demonstrated to activate the same EGF receptor-dependent pathway as doxorubicin, resulting in downregulation of GJC, caused strong phos-phorylation of Cx43 at serines 279 and 282. Thus, ERK-dependent downregulation of GJC upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation-independent manner.

Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells

1997 ◽  
Vol 114 (1-2) ◽  
pp. 207-210 ◽  
Author(s):  
Catherine Chaumontet ◽  
Catherine Droumaguet ◽  
Valérie Bex ◽  
Christine Heberden ◽  
Isabelle Gaillard-Sanchez ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Rat Liver ◽  
Intercellular Communication ◽  
Tumor Promoter ◽  
Liver Epithelial Cells ◽  
Rat Liver Epithelial Cells
Sign in / Sign up

Export Citation Format

Share Document