Quantitative Whole Body Autoradiographic Disposition of Glycol Ether in Mice: Effect of Route of Administration

1994 ◽  
Vol 22 (2) ◽  
pp. 266-276 ◽  
Author(s):  
A Ahmed
Keyword(s):  
Route Of Administration ◽  
Glycol Ether ◽  
Whole Body

Influence of route of administration on [ 3 H]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: whole-body autoradiographic studies

1996 ◽  
Vol 39 (1-2) ◽  
pp. 122-130 ◽  
Author(s):  
A. E. Ahmed ◽  
Sam Jacob ◽  
Beppino C. Giovanella ◽  
Anthony J. Kozielski ◽  
John S. Stehlin Jr. ◽  
...  
Keyword(s):  
Nude Mice ◽  
Route Of Administration ◽  
Whole Body ◽  
Tumor Uptake

Factors affecting the retention of 59Fe, 125I, and 51Cr by mice

1968 ◽  
Vol 46 (2) ◽  
pp. 201-205
Author(s):  
P. V. Vittorio ◽  
S. Dziubalo-Blehm ◽  
E. A. Watkins
Keyword(s):  
Serum Albumin ◽  
Route Of Administration ◽  
Whole Body ◽  
Sodium Chromate ◽  
Mode Of Administration ◽  
Factors Affecting ◽  
Body Counter ◽  
Ferrous Citrate ◽  
Whole Body Counter

The effect of fasting and whole-body exposure to radiation on the retention of 59Fe (ferrous citrate), 51Cr (sodium chromate), and 125I (radioiodinated serum albumin (human)), was studied in mice by means of a whole-body counter. The labelled compounds were administered orally, intraperitoneally, and intravenously. The present study indicates that fasting increases the rate of retention of the labelled compounds studied, and the extent of the increase is dependent upon the type of isotopic compound and the route of administration. Whole-body exposure to radiation (500 R) can also affect the retention of these labelled compounds and when affected there is always a decreased retention (increased excretion). The extent of the decrease is influenced by the type of tagged compound and the mode of administration.

Occurrence and biogeographic significance of Heliaster (Echinodermata: Asteroidea) from the Pliocene of southwest Florida

1988 ◽  
Vol 62 (01) ◽  
pp. 126-132 ◽  
Author(s):  
Douglas S. Jones ◽  
Roger W. Portell
Keyword(s):  
Central American ◽  
Eastern Pacific ◽  
Whole Body ◽  
Marine Fauna ◽  
Western Atlantic ◽  
Southwest Florida ◽  
Extant Species ◽  
Geologic Record ◽  
Central American Isthmus

Whole body asteroid fossils are rare in the geologic record and previously unreported from the Cenozoic of Florida. However, specimens of the extant species,Heliaster microbrachiusXantus, were recently discovered in upper Pliocene deposits. This marks the first reported fossil occurrence of the monogeneric Heliasteridae, a group today confined to the eastern Pacific. This discovery provides further non-molluscan evidence of the close similarities between the Neogene marine fauna of Florida and the modern fauna of the eastern Pacific. The extinction of the heliasters in the western Atlantic is consistent with the pattern of many other marine groups in the region which suffered impoverishment following uplift of the Central American isthmus.

Cerebral Tissue Response in Chronic Electrode Implantation

1977 ◽  
Vol 35 ◽  
pp. 624-625
Author(s):  
R.F. Dodson ◽  
L.W-F Chu ◽  
N. Ishihara
Keyword(s):  
Tissue Response ◽  
Whole Body ◽  
Platinum Electrodes ◽  
Fixed Tissue ◽  
Electrode Implantation ◽  
Surface Areas ◽  
Tissue Changes ◽  
Micron Diameter ◽  
Extent Of Damage ◽  
Electrode Sheath

The extent of damage surrounding an implanted electrode in the cerebral cortex is a question of significant importance with regard to attaining consistency and validity of physiological recordings. In order to determine the extent of such tissue changes, 150 micron diameter platinum electrodes were implanted in the cortex of four adult baboons, and after eight days the animals were sacrificed by whole body perfusion with a 3% glutaraldehyde in 0.1M phosphate fixative.The calvarium was carefully removed and the electrode tracts were readily discernible in the firm, glutaraldehyde fixed tissue.Careful dissection of the zone of the electrode tract resulted in a small block which was further sectioned into tip, mid-tract and surface areas. Ultrastructurally, damage extended from the electrode sheath to the greatest extent of from 0.2 to 3.5 mm.

Neutrophil Myeloperoxidase Destruction by Ultraviolet Irradiation

1988 ◽  
Vol 46 ◽  
pp. 138-139
Author(s):  
J. Hanker ◽  
B. Giammara ◽  
G. Strauss
Keyword(s):  
Uv Radiation ◽  
Myeloid Leukemia ◽  
Stratospheric Ozone ◽  
Psoriasis Patient ◽  
Whole Body ◽  
Human Neutrophils ◽  
Cupric Nitrate ◽  
The Earth ◽  
Routine Handling ◽  
Uvb Phototherapy

Only a fraction of the UV radiation emitted by the sun reaches the earth; most of the UVB (290-320nm) is eliminated by stratospheric ozone. There is increasing concern, however, that man-made chemicals are damaging this ozone layer. Although the effects of UV on DNA or as a carcinogen are widely known, preleukemia and acute myeloid leukemia (AML) have only rarely been reported in psoriasis patients treated with 8-methoxypsoralen and UV (PUVA). It was therefore of interest to study the effects of UV on the myeloperoxidase (MP) activity of human neutrophils. The peroxidase activity of enriched leukocyte preparations on coverslips was shown cytochemically with a diaminobenzidine medium and cupric nitrate intensification.Control samples (Figs. 1,4,5) of human bloods that were not specifically exposed to UV radiation or light except during routine handling were compared with samples which had been exposed in one of several different ways. One preparation (Fig. 2) was from a psoriasis patient who had received whole-body UVB phototherapy repeatedly.

Adipokines as key players in β cell function and failure

2019 ◽  
Vol 133 (22) ◽  
pp. 2317-2327 ◽  
Author(s):  
Nicolás Gómez-Banoy ◽  
James C. Lo
Keyword(s):  
Metabolic Diseases ◽  
Cell Function ◽  
Whole Body ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cell Axis ◽  
Β Cell Function ◽  
Prevalence Of Obesity ◽  
Specific Factors ◽  
Whole Body Metabolism

Abstract The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. These adipokines play crucial roles in whole-body metabolism with different mechanisms of action largely dependent on the tissue or cell type they are acting on. The pancreatic β cell, a key regulator of glucose metabolism due to its ability to produce and secrete insulin, has been identified as a target for several adipokines. This review will focus on how adipokines affect pancreatic β cell function and their impact on pancreatic β cell survival in disease contexts such as diabetes. Initially, the “classic” adipokines will be discussed, followed by novel secreted adipocyte-specific factors that show therapeutic promise in regulating the adipose–pancreatic β cell axis.

Quantifying Vocal Power: Correlation of Whole-Body Anaerobic Power to Vocal Function Measures

2020 ◽  
Vol 63 (8) ◽  
pp. 2597-2608
Author(s):  
Emily N. Snell ◽  
Laura W. Plexico ◽  
Aurora J. Weaver ◽  
Mary J. Sandage
Keyword(s):  
Fundamental Frequency ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Anaerobic Power ◽  
Performance Outcomes ◽  
Sound Level ◽  
Whole Body ◽  
Vocal Function ◽  
Laryngeal Diadochokinesis ◽  
High Sound

Purpose The purpose of this preliminary study was to identify a vocal task that could be used as a clinical indicator of the vocal aptitude or vocal fitness required for vocally demanding occupations in a manner similar to that of the anaerobic power tests commonly used in exercise science. Performance outcomes for vocal tasks that require rapid acceleration and high force production may be useful as an indirect indicator of muscle fiber complement and bioenergetic fitness of the larynx, an organ that is difficult to study directly. Method Sixteen women (age range: 19–24 years, M age = 22 years) were consented for participation and completed the following performance measures: forced vital capacity, three adapted vocal function tasks, and the horizontal sprint test. Results Using a within-participant correlational analyses, results indicated a positive relationship between the rate of the last second of a laryngeal diadochokinesis task that was produced at a high fundamental frequency/high sound level and anaerobic power. Forced vital capacity was not correlated with any of the vocal function tasks. Conclusions These preliminary results indicate that aspects of the laryngeal diadochokinesis task produced at a high fundamental frequency and high sound level may be useful as an ecologically valid measure of vocal power ability. Quantification of vocal power ability may be useful as a vocal fitness assessment or as an outcome measure for voice rehabilitation and habilitation for patients with vocally demanding jobs.

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