Plasmodium falciparum: Isolate-Specific Radiosensitivity

2001 ◽  
Vol 99 (2) ◽  
pp. 108-110 ◽  
Author(s):  
D.Sean Geoghegan ◽  
Tina Skinner-Adams ◽  
Timothy M.E. Davis
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Isolate

Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion

1989 ◽  
Vol 9 (8) ◽  
pp. 3584-3587
Author(s):  
R Cappai ◽  
M R van Schravendijk ◽  
R F Anders ◽  
M G Peterson ◽  
L M Thomas ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Surface Antigen ◽  
Infected Erythrocyte ◽  
Falciparum Isolate ◽  
Erythrocyte Surface ◽  
Subtelomeric Deletion

We show here that the Plasmodium falciparum isolate FCR3 does not express the ring-infected erythrocyte surface antigen (RESA). This is because the 5' end of the RESA gene has been inverted and partly deleted and a telomere has been added to it. We propose a model to explain these events.

The circumsporozoite protein gene from NF54, a Plasmodium falciparum isolate used in malaria vaccine trials

1989 ◽  
Vol 35 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Patrick Caspers ◽  
Reiner Gentz ◽  
Hugues Matile ◽  
J.Richard Pink ◽  
Francesco Sinigaglia
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Vaccine ◽  
Protein Gene ◽  
Circumsporozoite Protein ◽  
Falciparum Isolate ◽  
Vaccine Trials

Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate

2010 ◽  
Vol 173 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Stéphane Gangnard ◽  
Nicaise G. Tuikue Ndam ◽  
Sedami Gnidehou ◽  
Michael Quiviger ◽  
Alexandre Juillerat ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Isolate ◽  
Immunological Characterization

scholarly journals Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion.

1989 ◽  
Vol 9 (8) ◽  
pp. 3584-3587 ◽  
Author(s):  
R Cappai ◽  
M R van Schravendijk ◽  
R F Anders ◽  
M G Peterson ◽  
L M Thomas ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Surface Antigen ◽  
Infected Erythrocyte ◽  
Falciparum Isolate ◽  
Erythrocyte Surface ◽  
Subtelomeric Deletion

We show here that the Plasmodium falciparum isolate FCR3 does not express the ring-infected erythrocyte surface antigen (RESA). This is because the 5' end of the RESA gene has been inverted and partly deleted and a telomere has been added to it. We propose a model to explain these events.

A Plasmodium falciparum isolate with a chromosome 9 deletion expresses a trypsin-resistant cytoadherence molecule

1994 ◽  
Vol 67 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Sansanee C. Chaiyaroj ◽  
Ross L. Coppel ◽  
Cathleen Magowan ◽  
Graham V. Brown
Keyword(s):  
Plasmodium Falciparum ◽  
Chromosome 9 ◽  
Falciparum Isolate

scholarly journals Plasmodium falciparum isolate with histidine-rich protein 2 gene deletion from Nyala City, Western Sudan

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mohammed A. Boush ◽  
Moussa A. Djibrine ◽  
Ali Mussa ◽  
Mustafa Talib ◽  
A. Maki ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Deletion ◽  
Falciparum Isolate

scholarly journals Analysis of var genes cloned from a Plasmodium falciparum isolate in China

2012 ◽  
Vol 5 (2) ◽  
pp. 85-90
Author(s):  
Ning Jiang ◽  
Li Meng ◽  
Hui-Jun Lu ◽  
Wei Kang ◽  
Shuai Peng ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Isolate ◽  
Var Genes

scholarly journals Molecular Surveillance and Burden of Plasmodium falciparum Isolate to the Resistance of Artemisinin and Mefloquine-based Therapy among Febrile Subjects in Ilorin Metropolis, North-Central Nigeria

2021 ◽  
pp. 27-35
Author(s):  
Adebayo Sulaiman Nassar ◽  
Adeleye Solomon Bakarey ◽  
Abdulazeez Aderemi Abubakar ◽  
Michael Adeleke Oluwagbemiga ◽  
Shukurat Yetunde Alabi ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Mutation ◽  
Staining Technique ◽  
Relevant Information ◽  
High Rate ◽  
Falciparum Isolate ◽  
Molecular Surveillance ◽  
North Central ◽  
Combination Treatments ◽  
Structured Questionnaire

Introduction: Artemisinin-based combination treatments (ACTs) such as Artemisinin and mefloquine are generally accepted as the best forms of therapy for uncomplicated falciparum malaria and usually exceed more than 90% effectiveness. However, the problem of resistance to the target parasites remains a great challenge especially within the northcentral Nigeria. Therefore this study aimed to assess the burden of resistance of Plasmodium falciparum to artemisinin and Mefloquine from the blood smear febrile patients attending tertiary health facility in Ilorin, Nigeria. Methodology: The study was carried among two hundred and one (201) consented febrile individuals age ranged 1-46 years (Mean=22.7 years; M=39; F=61) between May and August 2019. Blood samples collected were subjected to Microscopy using Giemsa staining technique and Rapid diagnostic test (RDT) using (SD BIOLINE Malaria Ag P.f/Pv, South Korea) kit  to detect the presence of P. falciparum A semi-structured questionnaire was used to capture demographic and other relevant information while data was analysed with SPSS version 21. Results: Of the 201 samples tested, 113 (56.5%) were positive for Microscopy and RDT. Fifty of the positive samples for Microscopy and RDT were further subjected to PCR technique for the presence of Plasmodium falciparum and amplification of Kelch13 and FR1gene mutation of which one (2.0%) showed amplification for the PfKelch13 gene mutation for artemisinin while none was recorded for FR1 gene mutation in case of Mefloquine. Conclusion: This study reported a high rate of detection for Plasmodium falciparum using microscopy and RDT but moderately low rate of resistance to amplification for the PfKelch13 gene mutation for artemisinin but none for FR1 gene mutation for mefloquine by PCR. This suggests a clue for further monitoring of the artemisinin and Mefloquine resistance by detection of some molecular markers in k13 and FRI genes of Plasmodium in our communities in Nigeria.

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