Entamoeba histolytica: Monoclonal Antibody against the β1 Integrin-like Molecule (140 kDa) Inhibits Cell Adhesion to Extracellular Matrix Components

2001 ◽  
Vol 98 (2) ◽  
pp. 83-89 ◽  
Author(s):  
K. Sengupta ◽  
V.I. Hernández-Ramírez ◽  
A. Rios ◽  
R. Mondragón ◽  
P. Talamás-Rohana
Keyword(s):  
Monoclonal Antibody ◽  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Entamoeba Histolytica ◽  
Β1 Integrin ◽  
Extracellular Matrix Components ◽  
Matrix Components

scholarly journals What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics

2007 ◽  
Vol 156 (2) ◽  
pp. 143-153 ◽  
Author(s):  
Alper Gürlek ◽  
Niki Karavitaki ◽  
Olaf Ansorge ◽  
John A H Wass
Keyword(s):  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Growth Factor ◽  
Molecular Mechanisms ◽  
Cellular Migration ◽  
Tumour Suppressor Genes ◽  
Suprasellar Region ◽  
Extracellular Matrix Components ◽  
Matrix Components ◽  
E Cadherin

Prolactinoma is the most common pituitary tumour in adults. Macroprolactinomas, particularly in men, may occasionally exhibit a very aggressive clinical course as evidenced by progressive growth, invasion through bone into the sphenoid sinus, cavernous sinus, suprasellar region or the nasopharynx. Some may even progress to pituitary carcinoma with craniospinal or systemic metastases. Aggressive tumours have low cure rates despite appropriate medical and surgical treatment. The mechanisms underlying this aggressive biological behaviour have not yet been fully clarified. Recent immunohistochemical, molecular and genetic studies have provided some insight in this respect. Invasive prolactinomas may be associated with a high Ki-67/MIB-1 labelling index indicating increased cell proliferation, although this is not a universal finding. The AA polymorphism in the cyclin adenine (A)/guanine (G) gene is more frequently detected in invasive prolactinomas. Increased expression of the polysialylated neural cell adhesion molecule (NCAM) and reduced expression of the E-cadherin/catenin complex implies a contribution of altered cell-to-cell adhesion and cellular migration. Extracellular matrix components (ECM), matrix metalloproteinases (MMPs) and their inhibitors play important roles in the context of angiogenesis and invasion. The induction of fibroblast growth factor and vascular endothelial growth factor via oestrogen-induced overexpression of novel genes (PTTG, hst and Edpm5) enhance cell growth, proliferation and angiogenesis contributing to invasiveness in prolactinomas. Although mutations in proto-oncogenes like Ras are uncommon, loss of tumour suppressor genes at loci 11q13, 13q12–14, 10q and 1p seem to be associated with invasiveness. Of the described mechanisms, only reduced E-cadherin/catenin expression and overexpression of hst gene seem to be relatively specific markers for prolactinoma invasiveness compared with other pituitary adenomas. Further research is needed to clarify the molecular mechanisms behind the aggressive course of some prolactinomas to predict those with a potentially poor clinical outcome, and to devise treatments that will eventually enable the cure of these challenging tumours.

scholarly journals Exogenous nitric oxide inhibits mesangial cell adhesion to extracellular matrix components

1998 ◽  
Vol 53 (3) ◽  
pp. 598-608 ◽  
Author(s):  
Jian Yao ◽  
Harald O. Schoecklmann ◽  
Felicitas Pröls ◽  
Stefan Gauer ◽  
R. Bernd Sterzel
Keyword(s):  
Nitric Oxide ◽  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Mesangial Cell ◽  
Extracellular Matrix Components ◽  
Exogenous Nitric Oxide ◽  
Matrix Components
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